Association between Metrnl and carotid atherosclerosis in patients with type 2 diabetes mellitus
ObjectiveType 2 diabetes mellitus (T2DM) is a major cause of atherosclerosis, as well as an independent risk factor of cardiovascular adverse events. We aimed to evaluate the association of serum Meteorin-like protein (Metrnl) level with carotid atherosclerosis as determined by carotid intima-media...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1414508/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841555654994558976 |
|---|---|
| author | Chunmei Li Chunmei Li Qiongzhu Huang Qiongzhu Huang Yanqian Zhuang Yanqian Zhuang Pin Chen Pin Chen Yiyang Lin Yiyang Lin |
| author_facet | Chunmei Li Chunmei Li Qiongzhu Huang Qiongzhu Huang Yanqian Zhuang Yanqian Zhuang Pin Chen Pin Chen Yiyang Lin Yiyang Lin |
| author_sort | Chunmei Li |
| collection | DOAJ |
| description | ObjectiveType 2 diabetes mellitus (T2DM) is a major cause of atherosclerosis, as well as an independent risk factor of cardiovascular adverse events. We aimed to evaluate the association of serum Meteorin-like protein (Metrnl) level with carotid atherosclerosis as determined by carotid intima-media thickness (CIMT) status in subjects with T2DM.MethodsThis cross-sectional study included 83 T2DM subjects without pre-existing cardiovascular diseases. CIMT was measured by color doppler ultrasonography, while serum Metrnl level was measured by Enzyme-linked Immunosorbent Assay (ELISA) assay. According to the CIMT status, the subjects were divided into two groups: T2DM without atherosclerosis (DM-AS, CIMT<1.0mm) and T2DM with atherosclerosis (DM+AS, CIMT ≥1.0mm or carotid plaque).ResultsSerum Metrnl level was significantly increased in DM+AS group as compared to DM-AS group (0.77 ± 0.24 vs 0.51 ± 0.28 ng/ml, P <0.05). Binary logistic regression analysis showed that T2DM subjects in the fourth quartile of Metrnl levels demonstrated significantly higher risk of the presence of carotid atherosclerosis (P <0.05). The ROC curve used to identify the diagnostic accuracy of serum Metrnl level in the predication of T2DM subjects with carotid atherosclerosis revealed an area under the curve (AUC) of 0.742. The optimal cut-off value was 0.61 ng/ml with a sensitivity of 77.6% and a specificity of 58.8%.ConclusionsThis cross-sectional study clearly demonstrated that elevated serum Metrnl level was significantly associated with higher risk of the presence of carotid atherosclerosis. Metrnl is a promising therapeutic target for T2DM and its macro-vascular diseases. |
| format | Article |
| id | doaj-art-1749776a150c4aeaa27be0678449e29c |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-1749776a150c4aeaa27be0678449e29c2025-01-08T05:10:30ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.14145081414508Association between Metrnl and carotid atherosclerosis in patients with type 2 diabetes mellitusChunmei Li0Chunmei Li1Qiongzhu Huang2Qiongzhu Huang3Yanqian Zhuang4Yanqian Zhuang5Pin Chen6Pin Chen7Yiyang Lin8Yiyang Lin9Department of Endocrine, The 900th Hospital of Joint Logistic Support Force, the Chinese People's Liberation Army (PLA), Fuzhou, ChinaDepartment of Endocrine, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Endocrine, The 900th Hospital of Joint Logistic Support Force, the Chinese People's Liberation Army (PLA), Fuzhou, ChinaDepartment of Endocrine, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Endocrine, The 900th Hospital of Joint Logistic Support Force, the Chinese People's Liberation Army (PLA), Fuzhou, ChinaDepartment of Endocrine, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Endocrine, The 900th Hospital of Joint Logistic Support Force, the Chinese People's Liberation Army (PLA), Fuzhou, ChinaDepartment of Endocrine, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Endocrine, The 900th Hospital of Joint Logistic Support Force, the Chinese People's Liberation Army (PLA), Fuzhou, ChinaDepartment of Endocrine, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, ChinaObjectiveType 2 diabetes mellitus (T2DM) is a major cause of atherosclerosis, as well as an independent risk factor of cardiovascular adverse events. We aimed to evaluate the association of serum Meteorin-like protein (Metrnl) level with carotid atherosclerosis as determined by carotid intima-media thickness (CIMT) status in subjects with T2DM.MethodsThis cross-sectional study included 83 T2DM subjects without pre-existing cardiovascular diseases. CIMT was measured by color doppler ultrasonography, while serum Metrnl level was measured by Enzyme-linked Immunosorbent Assay (ELISA) assay. According to the CIMT status, the subjects were divided into two groups: T2DM without atherosclerosis (DM-AS, CIMT<1.0mm) and T2DM with atherosclerosis (DM+AS, CIMT ≥1.0mm or carotid plaque).ResultsSerum Metrnl level was significantly increased in DM+AS group as compared to DM-AS group (0.77 ± 0.24 vs 0.51 ± 0.28 ng/ml, P <0.05). Binary logistic regression analysis showed that T2DM subjects in the fourth quartile of Metrnl levels demonstrated significantly higher risk of the presence of carotid atherosclerosis (P <0.05). The ROC curve used to identify the diagnostic accuracy of serum Metrnl level in the predication of T2DM subjects with carotid atherosclerosis revealed an area under the curve (AUC) of 0.742. The optimal cut-off value was 0.61 ng/ml with a sensitivity of 77.6% and a specificity of 58.8%.ConclusionsThis cross-sectional study clearly demonstrated that elevated serum Metrnl level was significantly associated with higher risk of the presence of carotid atherosclerosis. Metrnl is a promising therapeutic target for T2DM and its macro-vascular diseases.https://www.frontiersin.org/articles/10.3389/fendo.2024.1414508/fullMetrnlcarotid atherosclerosiscarotid intima-media thicknesstype 2 diabetes mellituscross-sectional study |
| spellingShingle | Chunmei Li Chunmei Li Qiongzhu Huang Qiongzhu Huang Yanqian Zhuang Yanqian Zhuang Pin Chen Pin Chen Yiyang Lin Yiyang Lin Association between Metrnl and carotid atherosclerosis in patients with type 2 diabetes mellitus Frontiers in Endocrinology Metrnl carotid atherosclerosis carotid intima-media thickness type 2 diabetes mellitus cross-sectional study |
| title | Association between Metrnl and carotid atherosclerosis in patients with type 2 diabetes mellitus |
| title_full | Association between Metrnl and carotid atherosclerosis in patients with type 2 diabetes mellitus |
| title_fullStr | Association between Metrnl and carotid atherosclerosis in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Association between Metrnl and carotid atherosclerosis in patients with type 2 diabetes mellitus |
| title_short | Association between Metrnl and carotid atherosclerosis in patients with type 2 diabetes mellitus |
| title_sort | association between metrnl and carotid atherosclerosis in patients with type 2 diabetes mellitus |
| topic | Metrnl carotid atherosclerosis carotid intima-media thickness type 2 diabetes mellitus cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1414508/full |
| work_keys_str_mv | AT chunmeili associationbetweenmetrnlandcarotidatherosclerosisinpatientswithtype2diabetesmellitus AT chunmeili associationbetweenmetrnlandcarotidatherosclerosisinpatientswithtype2diabetesmellitus AT qiongzhuhuang associationbetweenmetrnlandcarotidatherosclerosisinpatientswithtype2diabetesmellitus AT qiongzhuhuang associationbetweenmetrnlandcarotidatherosclerosisinpatientswithtype2diabetesmellitus AT yanqianzhuang associationbetweenmetrnlandcarotidatherosclerosisinpatientswithtype2diabetesmellitus AT yanqianzhuang associationbetweenmetrnlandcarotidatherosclerosisinpatientswithtype2diabetesmellitus AT pinchen associationbetweenmetrnlandcarotidatherosclerosisinpatientswithtype2diabetesmellitus AT pinchen associationbetweenmetrnlandcarotidatherosclerosisinpatientswithtype2diabetesmellitus AT yiyanglin associationbetweenmetrnlandcarotidatherosclerosisinpatientswithtype2diabetesmellitus AT yiyanglin associationbetweenmetrnlandcarotidatherosclerosisinpatientswithtype2diabetesmellitus |