The incidence of HLA-DQ2/DQ8 in Turkish children with celiac disease and a comparison of the geographical distribution of HLA-DQ
Introduction : Celiac disease (CD) is an auto-immune enteropathy that occurs in genetically pre-disposed people as a result of the consumption of gluten-containing foods. Aim : To identify the incidence of HLA-DQ2 and HLA-DQ8 observed in children with CD. Material and methods : In this study, we...
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Termedia Publishing House
2017-12-01
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| Series: | Gastroenterology Review |
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| Online Access: | https://www.termedia.pl/The-incidence-of-HLA-DQ2-DQ8-in-Turkish-children-with-celiac-disease-and-a-comparison-of-the-geographical-distribution-of-HLA-DQ,41,31242,1,1.html |
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| author | Ahmet Basturk Reha Artan Aygen Yilmaz |
| author_facet | Ahmet Basturk Reha Artan Aygen Yilmaz |
| author_sort | Ahmet Basturk |
| collection | DOAJ |
| description | Introduction : Celiac disease (CD) is an auto-immune enteropathy that occurs in genetically pre-disposed people as a result of the consumption of gluten-containing foods.
Aim : To identify the incidence of HLA-DQ2 and HLA-DQ8 observed in children with CD.
Material and methods : In this study, we focused on children ranging in age from 2 to 18 years and diagnosed with celiac disease. In our patients diagnosed with CD, in addition to tissue transglutaminase antibodies (anti-tTG), we also evaluated HLA-DQ2 B1 and HLA-DQ8 B1 alleles using the method of polymerase chain reaction (PCR)/sequence-specific oligonucleotide probes (Luminex®). The detection of 0201/0202 for HLA-DQ2 allele and 0302 for HLA-DQ8 allele was accepted as a positive result.
Results : The mean age of our patients with celiac disease was 7.42 ±3.18 years, and the female/male ratio was 1.5/1. Seventy-six percent of our patients were HLA-DQ2 and/or HLA-DQ8 positive, 67% were HLA-DQ2 positive, and 25% were HLA-DQ8 positive. Nevertheless, 24% of them were HLA-DQ2 and HLA-DQ8 negative. The incidence of HLA-DQ2 in the control group was 18.8% with a significant difference compared to the HLA-DQ2 incidence in the patient group (67%) (p < 0.05). Similarly the HLA-DQ8 incidence in the control group (5.7%) was significantly lower than the incidence in the patient group (25%) (p < 0.05).
Conclusions : The incidence of the patients diagnosed with CD, who are HLA-DQ2 and HLA-DQ8 negative, varies among different populations. |
| format | Article |
| id | doaj-art-1735ae0a6bb843b3bcf92c4307624923 |
| institution | Kabale University |
| issn | 1895-5770 1897-4317 |
| language | English |
| publishDate | 2017-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Gastroenterology Review |
| spelling | doaj-art-1735ae0a6bb843b3bcf92c43076249232025-01-10T14:06:15ZengTermedia Publishing HouseGastroenterology Review1895-57701897-43172017-12-0112425626110.5114/pg.2017.7209931242The incidence of HLA-DQ2/DQ8 in Turkish children with celiac disease and a comparison of the geographical distribution of HLA-DQAhmet BasturkReha ArtanAygen YilmazIntroduction : Celiac disease (CD) is an auto-immune enteropathy that occurs in genetically pre-disposed people as a result of the consumption of gluten-containing foods. Aim : To identify the incidence of HLA-DQ2 and HLA-DQ8 observed in children with CD. Material and methods : In this study, we focused on children ranging in age from 2 to 18 years and diagnosed with celiac disease. In our patients diagnosed with CD, in addition to tissue transglutaminase antibodies (anti-tTG), we also evaluated HLA-DQ2 B1 and HLA-DQ8 B1 alleles using the method of polymerase chain reaction (PCR)/sequence-specific oligonucleotide probes (Luminex®). The detection of 0201/0202 for HLA-DQ2 allele and 0302 for HLA-DQ8 allele was accepted as a positive result. Results : The mean age of our patients with celiac disease was 7.42 ±3.18 years, and the female/male ratio was 1.5/1. Seventy-six percent of our patients were HLA-DQ2 and/or HLA-DQ8 positive, 67% were HLA-DQ2 positive, and 25% were HLA-DQ8 positive. Nevertheless, 24% of them were HLA-DQ2 and HLA-DQ8 negative. The incidence of HLA-DQ2 in the control group was 18.8% with a significant difference compared to the HLA-DQ2 incidence in the patient group (67%) (p < 0.05). Similarly the HLA-DQ8 incidence in the control group (5.7%) was significantly lower than the incidence in the patient group (25%) (p < 0.05). Conclusions : The incidence of the patients diagnosed with CD, who are HLA-DQ2 and HLA-DQ8 negative, varies among different populations.https://www.termedia.pl/The-incidence-of-HLA-DQ2-DQ8-in-Turkish-children-with-celiac-disease-and-a-comparison-of-the-geographical-distribution-of-HLA-DQ,41,31242,1,1.htmlceliac disease HLA DQ child |
| spellingShingle | Ahmet Basturk Reha Artan Aygen Yilmaz The incidence of HLA-DQ2/DQ8 in Turkish children with celiac disease and a comparison of the geographical distribution of HLA-DQ Gastroenterology Review celiac disease HLA DQ child |
| title | The incidence of HLA-DQ2/DQ8 in Turkish children with celiac disease and a comparison of the geographical distribution of HLA-DQ |
| title_full | The incidence of HLA-DQ2/DQ8 in Turkish children with celiac disease and a comparison of the geographical distribution of HLA-DQ |
| title_fullStr | The incidence of HLA-DQ2/DQ8 in Turkish children with celiac disease and a comparison of the geographical distribution of HLA-DQ |
| title_full_unstemmed | The incidence of HLA-DQ2/DQ8 in Turkish children with celiac disease and a comparison of the geographical distribution of HLA-DQ |
| title_short | The incidence of HLA-DQ2/DQ8 in Turkish children with celiac disease and a comparison of the geographical distribution of HLA-DQ |
| title_sort | incidence of hla dq2 dq8 in turkish children with celiac disease and a comparison of the geographical distribution of hla dq |
| topic | celiac disease HLA DQ child |
| url | https://www.termedia.pl/The-incidence-of-HLA-DQ2-DQ8-in-Turkish-children-with-celiac-disease-and-a-comparison-of-the-geographical-distribution-of-HLA-DQ,41,31242,1,1.html |
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