Chemical-Specific T Cell Tests Aim to Bridge a Gap in Skin Sensitization Evaluation

Chemical-Specific T Cell Tests Aim to Bridge a Gap in Skin Sensitization Evaluation

T cell activation is the final key event (KE4) in the adverse outcome pathway (AOP) of skin sensitization. However, validated new approach methodologies (NAMs) for evaluating this step are missing. Accordingly, chemicals that activate an unusually high frequency of T cells, as does the most prevalen...

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Bibliographic Details
Main Authors: Nele Fritsch, Marina Aparicio-Soto, Caterina Curato, Franziska Riedel, Hermann-Josef Thierse, Andreas Luch, Katherina Siewert
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Toxics
Subjects:
adverse outcome pathway
allergic contact dermatitis
chemical-induced T cell epitopes
contact allergens
in vitro T cell test
key events
Online Access:https://www.mdpi.com/2305-6304/12/11/802
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