The Relationship of Hematologic Parameters and Lipid Profile with Acute Ischemic Stroke
Objective: This study aims to investigate the effect of routine laboratory parameters on clinical outcomes in patients with acute ischemic stroke (AIS). Materials and Methods: Our study was designed as retrospective and cross-sectional. 94 patients with AIS who received inpatient treatment in our cl...
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Sakarya University
2024-12-01
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| Series: | Sakarya Tıp Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/4126718 |
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| author | Sibel Canbaz Kabay Fatma Akkoyun Arıkan Dursun Ceylan Merve Yatmazoğlu Çetin Niyazi Uysal Muhammed Alperen Bardakçı Gönül Akdağ Mustafa Çetiner Emine Saygın Uysal |
| author_facet | Sibel Canbaz Kabay Fatma Akkoyun Arıkan Dursun Ceylan Merve Yatmazoğlu Çetin Niyazi Uysal Muhammed Alperen Bardakçı Gönül Akdağ Mustafa Çetiner Emine Saygın Uysal |
| author_sort | Sibel Canbaz Kabay |
| collection | DOAJ |
| description | Objective: This study aims to investigate the effect of routine laboratory parameters on clinical outcomes in patients with acute ischemic stroke (AIS). Materials and Methods: Our study was designed as retrospective and cross-sectional. 94 patients with AIS who received inpatient treatment in our clinic with a diagnosis of acute ischemic stroke were included in the study. Laboratory data, demographic, and clinical characteristics were recorded at the time of admission. Neurological disabilities of the patients 3 months after treatment were evaluated with the modified Rankin Scale (mRS). mRS 0-2 was considered a good prognosis and mRS 3-6 was considered a poor prognosis. Results: Of the 94 patients included in the study, 47 were men and 47 were women. The mean age was 71.18±11.92 years. Laboratory parameters hemoglobin, eosinophil, totalcholesterol, ldl-cholesterol, and triglyceride values were significantly lower in the group with mRS≥3. As a result of ROC analysis, the area under the curve of hemoglobin, eosinophil, total-cholesterol, ldl-cholesterol, and triglyceride was significantly higher[(AUC: 0.710 95%CI: 0.60-0.81); Sensitivity=67.6%, Specificity=67.9%, p=0.001]. In the multivariable logistic regression model, only the NIHSS score (National Institutes Of Health Stroke Scale Scores) was independently associated with the degree of disability (p=0.001). NIHSS is an independent factor in predicting stroke outcomes. Conclusion: It was determined that there was a significant inverse relationship between the routine laboratory parameters hemoglobin level, eosinophil level, LDL and total cholesterol levels, and infarct volume with the NIHSS scores of hemoglobin and LDLcholesterol. |
| format | Article |
| id | doaj-art-172ed844c02a44e2b6e32cfb7eb99ae6 |
| institution | Kabale University |
| issn | 2146-409X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Sakarya University |
| record_format | Article |
| series | Sakarya Tıp Dergisi |
| spelling | doaj-art-172ed844c02a44e2b6e32cfb7eb99ae62025-01-07T09:05:44ZengSakarya UniversitySakarya Tıp Dergisi2146-409X2024-12-0114433434310.31832/smj.152915328The Relationship of Hematologic Parameters and Lipid Profile with Acute Ischemic StrokeSibel Canbaz Kabay0https://orcid.org/0000-0003-4808-2191Fatma Akkoyun Arıkan1https://orcid.org/0000-0002-3543-6213Dursun Ceylan2https://orcid.org/0000-0001-5110-1248Merve Yatmazoğlu Çetin3https://orcid.org/0009-0002-3329-6082Niyazi Uysal4https://orcid.org/0000-0003-0094-6480Muhammed Alperen Bardakçı5https://orcid.org/0000-0001-9169-7429Gönül Akdağ6https://orcid.org/0000-0002-0486-6026Mustafa Çetiner7https://orcid.org/0000-0002-4420-6452Emine Saygın Uysal8https://orcid.org/0009-0009-9979-355XKUTAHYA HEALTH SCIENCES UNIVERSITY, SCHOOL OF MEDICINEKUTAHYA HEALTH SCIENCES UNIVERSITY, SCHOOL OF MEDICINEKUTAHYA HEALTH SCIENCES UNIVERSITY, SCHOOL OF MEDICINEKUTAHYA HEALTH SCIENCES UNIVERSITY, SCHOOL OF MEDICINEKUTAHYA HEALTH SCIENCES UNIVERSITY, SCHOOL OF MEDICINEKUTAHYA HEALTH SCIENCES UNIVERSITY, SCHOOL OF MEDICINEKUTAHYA HEALTH SCIENCES UNIVERSITY, SCHOOL OF MEDICINEKUTAHYA HEALTH SCIENCES UNIVERSITY, SCHOOL OF MEDICINEKUTAHYA HEALTH SCIENCES UNIVERSITY, SCHOOL OF MEDICINEObjective: This study aims to investigate the effect of routine laboratory parameters on clinical outcomes in patients with acute ischemic stroke (AIS). Materials and Methods: Our study was designed as retrospective and cross-sectional. 94 patients with AIS who received inpatient treatment in our clinic with a diagnosis of acute ischemic stroke were included in the study. Laboratory data, demographic, and clinical characteristics were recorded at the time of admission. Neurological disabilities of the patients 3 months after treatment were evaluated with the modified Rankin Scale (mRS). mRS 0-2 was considered a good prognosis and mRS 3-6 was considered a poor prognosis. Results: Of the 94 patients included in the study, 47 were men and 47 were women. The mean age was 71.18±11.92 years. Laboratory parameters hemoglobin, eosinophil, totalcholesterol, ldl-cholesterol, and triglyceride values were significantly lower in the group with mRS≥3. As a result of ROC analysis, the area under the curve of hemoglobin, eosinophil, total-cholesterol, ldl-cholesterol, and triglyceride was significantly higher[(AUC: 0.710 95%CI: 0.60-0.81); Sensitivity=67.6%, Specificity=67.9%, p=0.001]. In the multivariable logistic regression model, only the NIHSS score (National Institutes Of Health Stroke Scale Scores) was independently associated with the degree of disability (p=0.001). NIHSS is an independent factor in predicting stroke outcomes. Conclusion: It was determined that there was a significant inverse relationship between the routine laboratory parameters hemoglobin level, eosinophil level, LDL and total cholesterol levels, and infarct volume with the NIHSS scores of hemoglobin and LDLcholesterol.https://dergipark.org.tr/tr/download/article-file/4126718acute ischemic strokelaboratoryinfarct volumeclinical outcomeakut iskemik inmelaboratuvarinfarkt hacmiklinik sonuç |
| spellingShingle | Sibel Canbaz Kabay Fatma Akkoyun Arıkan Dursun Ceylan Merve Yatmazoğlu Çetin Niyazi Uysal Muhammed Alperen Bardakçı Gönül Akdağ Mustafa Çetiner Emine Saygın Uysal The Relationship of Hematologic Parameters and Lipid Profile with Acute Ischemic Stroke Sakarya Tıp Dergisi acute ischemic stroke laboratory infarct volume clinical outcome akut iskemik inme laboratuvar infarkt hacmi klinik sonuç |
| title | The Relationship of Hematologic Parameters and Lipid Profile with Acute Ischemic Stroke |
| title_full | The Relationship of Hematologic Parameters and Lipid Profile with Acute Ischemic Stroke |
| title_fullStr | The Relationship of Hematologic Parameters and Lipid Profile with Acute Ischemic Stroke |
| title_full_unstemmed | The Relationship of Hematologic Parameters and Lipid Profile with Acute Ischemic Stroke |
| title_short | The Relationship of Hematologic Parameters and Lipid Profile with Acute Ischemic Stroke |
| title_sort | relationship of hematologic parameters and lipid profile with acute ischemic stroke |
| topic | acute ischemic stroke laboratory infarct volume clinical outcome akut iskemik inme laboratuvar infarkt hacmi klinik sonuç |
| url | https://dergipark.org.tr/tr/download/article-file/4126718 |
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