Thyroid Hormones and Interference in Thyroid Function Tests: A Review

The objective of this paper was to provide a critical and concise review on thyroid hormones and what constitutes interference in thyroid function tests using appropriate Online resources.Thethyroid function tests, play a valuable and significant role in diagnosing and managing thyroid disease. Dis...

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Main Authors: O. O. Edet, E. A. Omon, M. C. Agwu, A. N. Eze, M. E. Nwigube
Format: Article
Language:English
Published: Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP) 2024-11-01
Series:Journal of Applied Sciences and Environmental Management
Subjects:
Online Access:https://www.ajol.info/index.php/jasem/article/view/282472
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author O. O. Edet
E. A. Omon
M. C. Agwu
A. N. Eze
M. E. Nwigube
author_facet O. O. Edet
E. A. Omon
M. C. Agwu
A. N. Eze
M. E. Nwigube
author_sort O. O. Edet
collection DOAJ
description The objective of this paper was to provide a critical and concise review on thyroid hormones and what constitutes interference in thyroid function tests using appropriate Online resources.Thethyroid function tests, play a valuable and significant role in diagnosing and managing thyroid disease. Discordance can exist between test results and symptoms, leading to false laboratory reports, misdiagnosis, and mismanagement of thyroid disease. Interference in thyroid function tests can be caused by heterophile antibodies, macro TSH, biotin interference, anti-streptavidin and anti-ruthenium antibodies, thyroid hormone antibodies, and the high dose hook effect. This review paper also discusses the importance of studying interference, the mechanical perspectives of interference, and protocols to limit or eliminate interference in thyroid function assays. Additionally, it highlights quality control and laboratory safety aspects, as well as advancements in healthcare team deliveries related to thyroid function tests.
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institution Kabale University
issn 2659-1502
2659-1499
language English
publishDate 2024-11-01
publisher Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)
record_format Article
series Journal of Applied Sciences and Environmental Management
spelling doaj-art-1724edb9dac64d82bf077f341f4dc5432024-11-15T19:50:02ZengJoint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)Journal of Applied Sciences and Environmental Management2659-15022659-14992024-11-012811Thyroid Hormones and Interference in Thyroid Function Tests: A ReviewO. O. EdetE. A. OmonM. C. AgwuA. N. EzeM. E. Nwigube The objective of this paper was to provide a critical and concise review on thyroid hormones and what constitutes interference in thyroid function tests using appropriate Online resources.Thethyroid function tests, play a valuable and significant role in diagnosing and managing thyroid disease. Discordance can exist between test results and symptoms, leading to false laboratory reports, misdiagnosis, and mismanagement of thyroid disease. Interference in thyroid function tests can be caused by heterophile antibodies, macro TSH, biotin interference, anti-streptavidin and anti-ruthenium antibodies, thyroid hormone antibodies, and the high dose hook effect. This review paper also discusses the importance of studying interference, the mechanical perspectives of interference, and protocols to limit or eliminate interference in thyroid function assays. Additionally, it highlights quality control and laboratory safety aspects, as well as advancements in healthcare team deliveries related to thyroid function tests. https://www.ajol.info/index.php/jasem/article/view/282472Thyroid hormones; immunoassays; interferences; thyroid function
spellingShingle O. O. Edet
E. A. Omon
M. C. Agwu
A. N. Eze
M. E. Nwigube
Thyroid Hormones and Interference in Thyroid Function Tests: A Review
Journal of Applied Sciences and Environmental Management
Thyroid hormones; immunoassays; interferences; thyroid function
title Thyroid Hormones and Interference in Thyroid Function Tests: A Review
title_full Thyroid Hormones and Interference in Thyroid Function Tests: A Review
title_fullStr Thyroid Hormones and Interference in Thyroid Function Tests: A Review
title_full_unstemmed Thyroid Hormones and Interference in Thyroid Function Tests: A Review
title_short Thyroid Hormones and Interference in Thyroid Function Tests: A Review
title_sort thyroid hormones and interference in thyroid function tests a review
topic Thyroid hormones; immunoassays; interferences; thyroid function
url https://www.ajol.info/index.php/jasem/article/view/282472
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