Decreased Autophagic Activity in Triple-Negative Breast Cancer Cells upon Hydroxychloroquine and Thymoquinone Combination Treatment

Decreased Autophagic Activity in Triple-Negative Breast Cancer Cells upon Hydroxychloroquine and Thymoquinone Combination Treatment

Objective: Autophagy plays a significant role in breast cancer tumorigenesis, including triple-negative breast cancer. Research indicates that hydroxychloroquine and thymoquinone modulate autophagy, potentially suppressing its activity. However, their combined effects on aut...

Full description

Saved in:

Bibliographic Details
Main Authors:	Tuğcan Korak, Merve Gulsen Bal Albayrak, Sevinc Yanar, Gürler Akpınar, Murat Kasap
Format:	Article
Language:	English
Published:	Hitit University 2024-10-01
Series:	Hitit Medical Journal
Online Access:	https://dergipark.org.tr/tr/doi/10.52827/hititmedj.1472196
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Decreased Perifoveal Sensitivity Detected by Microperimetry in Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies
by: A. Molina-Martín, et al.
Published: (2015-01-01)

Potential therapeutic effect of thymoquinone on cisplatin-induced hepatotoxicity in rats
by: Sercan Kaya, et al.
Published: (2024-03-01)

Excessive Weight Gain During Pregnancy Increased Ponoxarase 1 Level in Neonatal Cord Blood
by: Serhat Ege, et al.
Published: (2025-01-01)

Histopathological evaluation of the effects of thymoquinone and resveratrol on the liver in rats administered doxorubicin
by: Mehmet Burak Ates, et al.
Published: (2022-09-01)

Gallic acid showed neuroprotection against endoplasmic reticulum stress in rats
by: Abdulmutalip Karaaslanlı, et al.
Published: (2025-01-01)

Hydroxychloroquine’s Early Impact on Cone Density
by: Tomoko Ueda-Consolvo, et al.
Published: (2021-01-01)

Stability study of thymoquinone, carvacrol and thymol using HPLC-UV and LC-ESI-MS
by: Soliman Rabab M., et al.
Published: (2020-09-01)

Anti‐retinal Autoantibodies in Hydroxychloroquine Eye Toxicity
by: Samuel D. Good, et al.
Published: (2025-01-01)

Analysis of hydroxychloroquine prescriptions for COVID‐19 in Japan
by: Takashi Watari, et al.
Published: (2023-05-01)

The beneficial effects of thymoquinone on viability and differentiation of human adipose tissue-derived mesenchymal stem cells
by: Ahsen Erginsoy, et al.
Published: (2024-04-01)

Protective effect of nigella sativa and thymoquinone on relative liver weight increase caused by aflatoxin in broilers
by: Mehmet Burak Ateş, et al.
Published: (2020-06-01)

Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin
by: Neeraj Khatri, et al.
Published: (2014-01-01)

Autophagic flux modulates tumor heterogeneity and lineage plasticity in SCLC
by: Yujie Hao, et al.
Published: (2025-01-01)

Liposomal Formulation of Hydroxychloroquine Can Inhibit Autophagy In Vivo
by: Wieslawa H. Dragowska, et al.
Published: (2024-12-01)

Deciphering the dose-dependent effects of thymoquinone on cellular proliferation and transcriptomic changes in A172 glioblastoma cells.
by: Rachana Pandey, et al.
Published: (2025-01-01)

A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer’s disease
by: Doha El-Sayed Ellakwa, et al.
Published: (2025-12-01)

Triple Incretin Agonists in Diabetes Mellitus: Retatrutide Improves Lipid Profile and Decreases Blood Pressure
by: Nuri Barış Hasbal, et al.
Published: (2025-01-01)

Hydroxychloroquine Effects on TLR Signalling: Underexposed but Unneglectable in COVID-19
by: Aliede E. in ‘t Veld, et al.
Published: (2021-01-01)

The Active Compound Thymoquinone Alters Chondrogenic Differentiation of Human Mesenchymal Stem Cells via Modulation of Intracellular Signaling
by: Banu ISKENDER
Published: (2022-03-01)

Fabrication of Thymoquinone and Ascorbic Acid-Loaded Spanlastics Gel for Hyperpigmentation: In Vitro Release, Cytotoxicity, and Skin Permeation Studies
by: Ahlam Zaid Alkilani, et al.
Published: (2025-01-01)

A Case of Severe Hydroxychloroquine-Induced Retinal Toxicity in a Patient with Recent Onset of Renal Impairment: A Review of the Literature on the Use of Hydroxychloroquine in Renal Impairment
by: Rajen Tailor, et al.
Published: (2012-01-01)

AMPK Activation in TET2 Downregulated Leukemia Cells Upon Glutamine Limitation
by: Ahsen Merve BAYRAK, et al.
Published: (2024-09-01)

Evaluation of the Fit of Additively and Subtractively Produced Resin-Based Crowns for Primary Teeth Using a Triple-Scan Protocol
by: Nagehan Aktaş, et al.
Published: (2024-12-01)

Upon this mountain
by: Wangusa, Timothy
Published: (2005)

Simultaneous Live Mapping of pH and Hydrogen Peroxide Fluctuations in Autophagic Vesicles
by: Smitaroopa Kahali, et al.
Published: (2025-01-01)

Synergistic Effects of Thymoquinone and Carob Powder versus Dexamethasone in the Model of Asthma in Pregnant Rats: New Insights into their Therapeutic Effects
by: Ameerah Fadhil Ahmed, et al.
Published: (2024-10-01)

Early detection of the retinal bioelectrical dysfunction in patients treated by chloroquine/hydroxychloroquine
by: Wojciech Lubiński, et al.
Published: (2024-12-01)

Risk versus Benefit of Using Hydroxychloroquine to Treat Patients with COVID-19
by: George G. Zhanel, et al.
Published: (2021-01-01)

Hydroxychloroquine-induced Sweet’s Syndrome: A Case Report and Literature Review
by: Gustavo Almeida-Silva, et al.
Published: (2025-01-01)

GABARAPL1 is essential for ACR-induced autophagic cell death of mouse Leydig cells
by: Jiahui Meng, et al.
Published: (2025-01-01)

Physiologically-based pharmacokinetic modeling of enantioselective hydroxychloroquine kinetics and impact of genetic polymorphisms
by: Gabriella de Souza Gomes Ribeiro, et al.
Published: (2025-01-01)

Optical coherence tomography characteristics in hydroxychloroquine retinopathy and the correlations with visual deterioration in Taiwanese
by: Shao-Kai He, et al.
Published: (2024-12-01)

Combination of Triple Therapy and Chronic PPI Use May Decrease Risk of Colonic Adenomatous Polyps in Helicobacter pylori Infection
by: Rina Zuniga, et al.
Published: (2015-01-01)

Brand Love and Brand Forgiveness: An Empirical Study in Turkey
by: Merve Yanar Gürce, et al.
Published: (2022-01-01)

Characterization of Triple Negative Breast Cancer
by: Bernardo Enrique Heredia Martínez, et al.
Published: (2020-09-01)

Deoxycholate, an Endogenous Cytotoxin/Genotoxin, Induces the Autophagic Stress-Survival Pathway: Implications for Colon Carcinogenesis
by: Claire M. Payne, et al.
Published: (2009-01-01)

Evaluation of autophagic and apoptotic markers during infection with animal virus causing hemorrhagic fever in rabbits
by: Dominika Bębnowska, et al.
Published: (2025-01-01)

OSP-1 protects neurons from autophagic cell death induced by acute oxidative stress
by: Alessandra Donato, et al.
Published: (2025-01-01)

Efficacy and Safety of Antimalarial as Repurposing Drug for COVID-19 Following Retraction of Chloroquine and Hydroxychloroquine
by: Latarissa IR, et al.
Published: (2025-01-01)

Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine
by: John P. O’Laughlin, et al.
Published: (2016-01-01)