The Hippo Signaling Pathway Manipulates Cellular Senescence
The Hippo pathway, a kinase cascade, coordinates with many intracellular signals and mediates the regulation of the activities of various downstream transcription factors and their coactivators to maintain homeostasis. Therefore, the aberrant activation of the Hippo pathway and its associated molecu...
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2024-12-01
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| author | Chiharu Miyajima Mai Nagasaka Hiromasa Aoki Kohki Toriuchi Shogo Yamanaka Sakura Hashiguchi Daisuke Morishita Mineyoshi Aoyama Hidetoshi Hayashi Yasumichi Inoue |
| author_facet | Chiharu Miyajima Mai Nagasaka Hiromasa Aoki Kohki Toriuchi Shogo Yamanaka Sakura Hashiguchi Daisuke Morishita Mineyoshi Aoyama Hidetoshi Hayashi Yasumichi Inoue |
| author_sort | Chiharu Miyajima |
| collection | DOAJ |
| description | The Hippo pathway, a kinase cascade, coordinates with many intracellular signals and mediates the regulation of the activities of various downstream transcription factors and their coactivators to maintain homeostasis. Therefore, the aberrant activation of the Hippo pathway and its associated molecules imposes significant stress on tissues and cells, leading to cancer, immune disorders, and a number of diseases. Cellular senescence, the mechanism by which cells counteract stress, prevents cells from unnecessary damage and leads to sustained cell cycle arrest. It acts as a powerful defense mechanism against normal organ development and aging-related diseases. On the other hand, the accumulation of senescent cells without their proper removal contributes to the development or worsening of cancer and age-related diseases. A correlation was recently reported between the Hippo pathway and cellular senescence, which preserves tissue homeostasis. This review is the first to describe the close relationship between aging and the Hippo pathway, and provides insights into the mechanisms of aging and the development of age-related diseases. In addition, it describes advanced findings that may lead to the development of tissue regeneration therapies and drugs targeting rejuvenation. |
| format | Article |
| id | doaj-art-17061634b0db4c3fbec1264605f86aef |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-17061634b0db4c3fbec1264605f86aef2025-01-10T13:16:15ZengMDPI AGCells2073-44092024-12-011411310.3390/cells14010013The Hippo Signaling Pathway Manipulates Cellular SenescenceChiharu Miyajima0Mai Nagasaka1Hiromasa Aoki2Kohki Toriuchi3Shogo Yamanaka4Sakura Hashiguchi5Daisuke Morishita6Mineyoshi Aoyama7Hidetoshi Hayashi8Yasumichi Inoue9Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanDepartment of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanDepartment of Pathobiology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanDepartment of Pathobiology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanDepartment of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanDepartment of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanDepartment of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanDepartment of Pathobiology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanDepartment of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanDepartment of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, JapanThe Hippo pathway, a kinase cascade, coordinates with many intracellular signals and mediates the regulation of the activities of various downstream transcription factors and their coactivators to maintain homeostasis. Therefore, the aberrant activation of the Hippo pathway and its associated molecules imposes significant stress on tissues and cells, leading to cancer, immune disorders, and a number of diseases. Cellular senescence, the mechanism by which cells counteract stress, prevents cells from unnecessary damage and leads to sustained cell cycle arrest. It acts as a powerful defense mechanism against normal organ development and aging-related diseases. On the other hand, the accumulation of senescent cells without their proper removal contributes to the development or worsening of cancer and age-related diseases. A correlation was recently reported between the Hippo pathway and cellular senescence, which preserves tissue homeostasis. This review is the first to describe the close relationship between aging and the Hippo pathway, and provides insights into the mechanisms of aging and the development of age-related diseases. In addition, it describes advanced findings that may lead to the development of tissue regeneration therapies and drugs targeting rejuvenation.https://www.mdpi.com/2073-4409/14/1/13Hippo pathwaycellular senescencecancer |
| spellingShingle | Chiharu Miyajima Mai Nagasaka Hiromasa Aoki Kohki Toriuchi Shogo Yamanaka Sakura Hashiguchi Daisuke Morishita Mineyoshi Aoyama Hidetoshi Hayashi Yasumichi Inoue The Hippo Signaling Pathway Manipulates Cellular Senescence Cells Hippo pathway cellular senescence cancer |
| title | The Hippo Signaling Pathway Manipulates Cellular Senescence |
| title_full | The Hippo Signaling Pathway Manipulates Cellular Senescence |
| title_fullStr | The Hippo Signaling Pathway Manipulates Cellular Senescence |
| title_full_unstemmed | The Hippo Signaling Pathway Manipulates Cellular Senescence |
| title_short | The Hippo Signaling Pathway Manipulates Cellular Senescence |
| title_sort | hippo signaling pathway manipulates cellular senescence |
| topic | Hippo pathway cellular senescence cancer |
| url | https://www.mdpi.com/2073-4409/14/1/13 |
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