Functional characterization of the α1-adrenoceptor in adult male rat locus coeruleus neurons ex vivo

Functional characterization of the α1-adrenoceptor in adult male rat locus coeruleus neurons ex vivo

IntroductionThe α1-adrenoceptor (α1AR) is involved in the physiopathology of the central nervous system (CNS), but its function in the adult male rat locus coeruleus (LC) has not been fully studied. We aimed to characterize the role of the α1AR in the regulation of the firing rate (FR) of LC neurons...

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Bibliographic Details
Main Authors: Irati Rodilla, Aitziber Mendiguren, Joseba Pineda
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
locus coeruleus
α1-adrenoceptor
slice
firing
noradrenaline
rat
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1626019/full
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