Clinical Association Between Psychotic Symptoms and the Gilbert Syndrome: A Case Report
Modern research in psychiatry is increasingly focusing on the possible identification of potentially useful biomarkers for early and differential diagnosis and patient-tailored therapy. In this context, old and new biomarkers are gaining attention, and bilirubin could represent a low-cost and widesp...
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| Format: | Article |
| Language: | English |
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IUC University Press
2024-06-01
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| Series: | Neuropsychiatric Investigation |
| Online Access: | https://neuropsychiatricinvestigation.org/en/clinical-association-between-psychotic-symptoms-and-the-gilbert-syndrome-a-case-report-13670 |
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| author | Balaswamy Reddy Alessandra Nocera Renato de Filippis Soumitra Das |
| author_facet | Balaswamy Reddy Alessandra Nocera Renato de Filippis Soumitra Das |
| author_sort | Balaswamy Reddy |
| collection | DOAJ |
| description | Modern research in psychiatry is increasingly focusing on the possible identification of potentially useful biomarkers for early and differential diagnosis and patient-tailored therapy. In this context, old and new biomarkers are gaining attention, and bilirubin could represent a low-cost and widespread tool in this regard. In the following paper, we present a case report of a patient with juvenile-onset schizophrenia successfully treated with oral risperidone on 2 separate occasions, whose clinical exacerbation phases overlapped with hyperbilirubinemia peaks, while comfort phases were associated with serum bilirubin within the normal range. The patient was later diagnosed with Gilbert’s syndrome, a benign, congenital condition of hyperbilirubinemia, with alternating phases of mostly asymptomatic bilirubin levels. This case highlights a possible relationship between psychotic symptoms and plasma bilirubin levels. While not representing by itself a sufficient condition to determine a relationship between the 2 phenomena, it poses a relevant question for future clinical and research investigations. |
| format | Article |
| id | doaj-art-16f833163f6e4d9394e7f812f3e74459 |
| institution | Kabale University |
| issn | 2792-0070 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | IUC University Press |
| record_format | Article |
| series | Neuropsychiatric Investigation |
| spelling | doaj-art-16f833163f6e4d9394e7f812f3e744592024-12-06T06:04:56ZengIUC University PressNeuropsychiatric Investigation2792-00702024-06-01622737510.5152/NeuropsychiatricInvest.2024.23019Clinical Association Between Psychotic Symptoms and the Gilbert Syndrome: A Case ReportBalaswamy Reddy0Alessandra Nocera1Renato de Filippis2Soumitra Das 3Department of Psychiatry, Junior Resident, National Institute of Mental Health and Neuro Sciences, Bengaluru, IndiaDepartment of Studies on Language and Culture, University of Modena and Reggio Emilia, Modena, Italy ; Department of Humanities, Social Sciences and Cultural Industries, University of Parma, Parma, Italy ; University Magna Graecia of Catanzaro, Catanzaro, ItalyPsychiatry Unit, Department of Health Science, University Magna Graecia of Catanzaro, Catanzaro, ItalyDepartment of Psychiatry, Senior Resident, NIMHANS, Bengaluru, IndiaModern research in psychiatry is increasingly focusing on the possible identification of potentially useful biomarkers for early and differential diagnosis and patient-tailored therapy. In this context, old and new biomarkers are gaining attention, and bilirubin could represent a low-cost and widespread tool in this regard. In the following paper, we present a case report of a patient with juvenile-onset schizophrenia successfully treated with oral risperidone on 2 separate occasions, whose clinical exacerbation phases overlapped with hyperbilirubinemia peaks, while comfort phases were associated with serum bilirubin within the normal range. The patient was later diagnosed with Gilbert’s syndrome, a benign, congenital condition of hyperbilirubinemia, with alternating phases of mostly asymptomatic bilirubin levels. This case highlights a possible relationship between psychotic symptoms and plasma bilirubin levels. While not representing by itself a sufficient condition to determine a relationship between the 2 phenomena, it poses a relevant question for future clinical and research investigations.https://neuropsychiatricinvestigation.org/en/clinical-association-between-psychotic-symptoms-and-the-gilbert-syndrome-a-case-report-13670 |
| spellingShingle | Balaswamy Reddy Alessandra Nocera Renato de Filippis Soumitra Das Clinical Association Between Psychotic Symptoms and the Gilbert Syndrome: A Case Report Neuropsychiatric Investigation |
| title | Clinical Association Between Psychotic Symptoms and the Gilbert Syndrome: A Case Report |
| title_full | Clinical Association Between Psychotic Symptoms and the Gilbert Syndrome: A Case Report |
| title_fullStr | Clinical Association Between Psychotic Symptoms and the Gilbert Syndrome: A Case Report |
| title_full_unstemmed | Clinical Association Between Psychotic Symptoms and the Gilbert Syndrome: A Case Report |
| title_short | Clinical Association Between Psychotic Symptoms and the Gilbert Syndrome: A Case Report |
| title_sort | clinical association between psychotic symptoms and the gilbert syndrome a case report |
| url | https://neuropsychiatricinvestigation.org/en/clinical-association-between-psychotic-symptoms-and-the-gilbert-syndrome-a-case-report-13670 |
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