Clinical Association Between Psychotic Symptoms and the Gilbert Syndrome: A Case Report
Modern research in psychiatry is increasingly focusing on the possible identification of potentially useful biomarkers for early and differential diagnosis and patient-tailored therapy. In this context, old and new biomarkers are gaining attention, and bilirubin could represent a low-cost and widesp...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IUC University Press
2024-06-01
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| Series: | Neuropsychiatric Investigation |
| Online Access: | https://neuropsychiatricinvestigation.org/en/clinical-association-between-psychotic-symptoms-and-the-gilbert-syndrome-a-case-report-13670 |
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| Summary: | Modern research in psychiatry is increasingly focusing on the possible identification of potentially useful biomarkers for early and differential diagnosis and patient-tailored therapy. In this context, old and new biomarkers are gaining attention, and bilirubin could represent a low-cost and widespread tool in this regard. In the following paper, we present a case report of a patient with juvenile-onset schizophrenia successfully treated with oral risperidone on 2 separate occasions, whose clinical exacerbation phases overlapped with hyperbilirubinemia peaks, while comfort phases were associated with serum bilirubin within the normal range. The patient was later diagnosed with Gilbert’s syndrome, a benign, congenital condition of hyperbilirubinemia, with alternating phases of mostly asymptomatic bilirubin levels. This case highlights a possible relationship between psychotic symptoms and plasma bilirubin levels. While not representing by itself a sufficient condition to determine a relationship between the 2 phenomena, it poses a relevant question for future clinical and research investigations. |
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| ISSN: | 2792-0070 |