Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa
Protein tyrosine phosphatases (PTPs) are a family of enzymes essential for numerous cellular processes, such as cell growth, inflammation, differentiation, immune-mediated responses and oncogenic transformation. The aim of this review is to review the literature concerning the role of several PTPs—P...
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2024-11-01
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| author | Claudia Bellomo Francesca Furone Roberta Rotondo Ilaria Ciscognetti Martina Carpinelli Martina Nicoletti Genoveffa D’Aniello Leandra Sepe Maria Vittoria Barone Merlin Nanayakkara |
| author_facet | Claudia Bellomo Francesca Furone Roberta Rotondo Ilaria Ciscognetti Martina Carpinelli Martina Nicoletti Genoveffa D’Aniello Leandra Sepe Maria Vittoria Barone Merlin Nanayakkara |
| author_sort | Claudia Bellomo |
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| description | Protein tyrosine phosphatases (PTPs) are a family of enzymes essential for numerous cellular processes, such as cell growth, inflammation, differentiation, immune-mediated responses and oncogenic transformation. The aim of this review is to review the literature concerning the role of several PTPs—PTPN22, PTPN2, PTPN6, PTPN11, PTPσ, DUSP2, DUSP6 and PTPRK—at the level of the intestinal mucosa in inflammatory bowel disease (IBD), celiac disease (CeD) and type 1 diabetes (T1D) in both in vitro and in vivo models. The results revealed shared features, at the level of the intestinal mucosa, between these diseases characterized by alterations of different biological processes, such as proliferation, autoimmunity, cell death, autophagy and inflammation. PTPs are now actively studied to develop new drugs. Also considering the availability of organoids as models to test new drugs in personalized ways, it is very likely that soon these proteins will be the targets of useful drugs. |
| format | Article |
| id | doaj-art-16f8084f939b4d5ba621b21ed9fffada |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-16f8084f939b4d5ba621b21ed9fffada2024-12-13T16:24:12ZengMDPI AGCells2073-44092024-11-011323198110.3390/cells13231981Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal MucosaClaudia Bellomo0Francesca Furone1Roberta Rotondo2Ilaria Ciscognetti3Martina Carpinelli4Martina Nicoletti5Genoveffa D’Aniello6Leandra Sepe7Maria Vittoria Barone8Merlin Nanayakkara9Department of Translational Medical Science, Section of Pediatrics, University Federico II, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Translational Medical Science, Section of Pediatrics, University Federico II, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Medicine and Surgery, University of Parma, 43121 Parma, ItalyDepartment of Translational Medical Science, Section of Pediatrics, University Federico II, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Translational Medical Science, Section of Pediatrics, University Federico II, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Translational Medical Science, Section of Pediatrics, University Federico II, Via S. Pansini 5, 80131 Naples, ItalyELFID (European Laboratory for the Investigation of Food-Induced Diseases), University Federico II, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Translational Medical Science, Section of Pediatrics, University Federico II, Via S. Pansini 5, 80131 Naples, ItalyFederico II University Hospital, 80131 Naples, ItalyProtein tyrosine phosphatases (PTPs) are a family of enzymes essential for numerous cellular processes, such as cell growth, inflammation, differentiation, immune-mediated responses and oncogenic transformation. The aim of this review is to review the literature concerning the role of several PTPs—PTPN22, PTPN2, PTPN6, PTPN11, PTPσ, DUSP2, DUSP6 and PTPRK—at the level of the intestinal mucosa in inflammatory bowel disease (IBD), celiac disease (CeD) and type 1 diabetes (T1D) in both in vitro and in vivo models. The results revealed shared features, at the level of the intestinal mucosa, between these diseases characterized by alterations of different biological processes, such as proliferation, autoimmunity, cell death, autophagy and inflammation. PTPs are now actively studied to develop new drugs. Also considering the availability of organoids as models to test new drugs in personalized ways, it is very likely that soon these proteins will be the targets of useful drugs.https://www.mdpi.com/2073-4409/13/23/1981protein tyrosine phosphatasesceliac diseasediabetesinflammatory bowel diseasesintestinal mucosa |
| spellingShingle | Claudia Bellomo Francesca Furone Roberta Rotondo Ilaria Ciscognetti Martina Carpinelli Martina Nicoletti Genoveffa D’Aniello Leandra Sepe Maria Vittoria Barone Merlin Nanayakkara Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa Cells protein tyrosine phosphatases celiac disease diabetes inflammatory bowel diseases intestinal mucosa |
| title | Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa |
| title_full | Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa |
| title_fullStr | Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa |
| title_full_unstemmed | Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa |
| title_short | Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa |
| title_sort | role of protein tyrosine phosphatases in inflammatory bowel disease celiac disease and diabetes focus on the intestinal mucosa |
| topic | protein tyrosine phosphatases celiac disease diabetes inflammatory bowel diseases intestinal mucosa |
| url | https://www.mdpi.com/2073-4409/13/23/1981 |
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