Revealing complexity: segmentation of hippocampal subfields in adolescents with major depressive disorder reveals specific links to cognitive dysfunctions
Abstract Background Hippocampal disruptions represent potential neuropathological biomarkers in depressed adolescents with cognitive dysfunctions. Given heterogeneous outcomes of whole-hippocampus analyses, we investigated subregional abnormalities in depressed adolescents and their associations w...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2025-01-01
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| Series: | European Psychiatry |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933824000154/type/journal_article |
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| author | Yixin Zhang Xuan Liu Ying Yang Yihao Zhang Qiang He Feiyu Xu Xinjuan Jin Junqi Gao Yuan Yao Dexin Yu Bernhard Hommel Xingxing Zhu Kangcheng Wang Wenxin Zhang |
| author_facet | Yixin Zhang Xuan Liu Ying Yang Yihao Zhang Qiang He Feiyu Xu Xinjuan Jin Junqi Gao Yuan Yao Dexin Yu Bernhard Hommel Xingxing Zhu Kangcheng Wang Wenxin Zhang |
| author_sort | Yixin Zhang |
| collection | DOAJ |
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Abstract
Background
Hippocampal disruptions represent potential neuropathological biomarkers in depressed adolescents with cognitive dysfunctions. Given heterogeneous outcomes of whole-hippocampus analyses, we investigated subregional abnormalities in depressed adolescents and their associations with symptom severity and cognitive dysfunctions.
Methods
MethodsSeventy-nine first-episode depressive patients (ag = 15.54 ± 1.83) and 71 healthy controls (age = 16.18 ± 2.85) were included. All participants underwent T1 and T2 imaging, completed depressive severity assessments, and performed cognitive assessments on memory, emotional recognition, cognitive control, and attention. Freesurfer was used to segment each hippocampus into 12 subfields. Multivariable analyses of variance were performed to identify overall and disease severity-related abnormalities in patients. LASSO regression was also conducted to explore the associations between hippocampal subfields and patients’ cognitive abilities.
Results
Depressed adolescents showed decreases in dentate gyrus, CA1, CA2/3, CA4, fimbria, tail, and molecular layer. Analyses of overall symptom severity, duration, self-harm behavior, and suicidality suggested that severity-related decreases mainly manifested in CA regions and involved surrounding subfields with disease severity increases. LASSO regression indicated that hippocampal subfield abnormalities had the strongest associations with memory impairments, with CA regions and dentate gyrus showing the highest weights.
Conclusions
Hippocampal abnormalities are widespread in depressed adolescents and such abnormalities may spread from CA regions to surrounding areas as the disease progresses. Abnormalities in CA regions and dentate gyrus among these subfields primarily link with memory impairments in patients. These results demonstrate that hippocampal subsections may serve as useful biomarkers of depression progression in adolescents, offering new directions for early clinical intervention.
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| format | Article |
| id | doaj-art-16ee1df8c09841bdb19fc2fac015b48d |
| institution | Kabale University |
| issn | 0924-9338 1778-3585 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj-art-16ee1df8c09841bdb19fc2fac015b48d2025-01-16T21:47:25ZengCambridge University PressEuropean Psychiatry0924-93381778-35852025-01-016810.1192/j.eurpsy.2024.15Revealing complexity: segmentation of hippocampal subfields in adolescents with major depressive disorder reveals specific links to cognitive dysfunctionsYixin Zhang0Xuan Liu1https://orcid.org/0009-0007-8557-0051Ying Yang2Yihao Zhang3https://orcid.org/0009-0001-9654-2319Qiang He4Feiyu Xu5Xinjuan Jin6Junqi Gao7Yuan Yao8https://orcid.org/0000-0002-0006-5678Dexin Yu9https://orcid.org/0000-0002-3430-4817Bernhard Hommel10https://orcid.org/0000-0003-4731-5125Xingxing Zhu11https://orcid.org/0000-0002-5453-1769Kangcheng Wang12https://orcid.org/0000-0002-3025-8294Wenxin Zhang13https://orcid.org/0000-0002-1281-287XSchool of Psychology, Shandong Normal University, Jinan, ChinaSchool of Psychology, Shandong Normal University, Jinan, ChinaShandong Mental Health Center, Jinan, ChinaSchool of Psychology, Shandong Normal University, Jinan, ChinaShandong Mental Health Center, Jinan, ChinaShandong Mental Health Center, Jinan, ChinaRadiology Department of Qilu Hospital, Shandong University, Jinan, ChinaRadiology Department of Qilu Hospital, Shandong University, Jinan, ChinaRadiology Department of Qilu Hospital, Shandong University, Jinan, ChinaRadiology Department of Qilu Hospital, Shandong University, Jinan, ChinaSchool of Psychology, Shandong Normal University, Jinan, ChinaInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UKSchool of Psychology, Shandong Normal University, Jinan, China Shandong Mental Health Center, Jinan, ChinaSchool of Psychology, Shandong Normal University, Jinan, China Abstract Background Hippocampal disruptions represent potential neuropathological biomarkers in depressed adolescents with cognitive dysfunctions. Given heterogeneous outcomes of whole-hippocampus analyses, we investigated subregional abnormalities in depressed adolescents and their associations with symptom severity and cognitive dysfunctions. Methods MethodsSeventy-nine first-episode depressive patients (ag = 15.54 ± 1.83) and 71 healthy controls (age = 16.18 ± 2.85) were included. All participants underwent T1 and T2 imaging, completed depressive severity assessments, and performed cognitive assessments on memory, emotional recognition, cognitive control, and attention. Freesurfer was used to segment each hippocampus into 12 subfields. Multivariable analyses of variance were performed to identify overall and disease severity-related abnormalities in patients. LASSO regression was also conducted to explore the associations between hippocampal subfields and patients’ cognitive abilities. Results Depressed adolescents showed decreases in dentate gyrus, CA1, CA2/3, CA4, fimbria, tail, and molecular layer. Analyses of overall symptom severity, duration, self-harm behavior, and suicidality suggested that severity-related decreases mainly manifested in CA regions and involved surrounding subfields with disease severity increases. LASSO regression indicated that hippocampal subfield abnormalities had the strongest associations with memory impairments, with CA regions and dentate gyrus showing the highest weights. Conclusions Hippocampal abnormalities are widespread in depressed adolescents and such abnormalities may spread from CA regions to surrounding areas as the disease progresses. Abnormalities in CA regions and dentate gyrus among these subfields primarily link with memory impairments in patients. These results demonstrate that hippocampal subsections may serve as useful biomarkers of depression progression in adolescents, offering new directions for early clinical intervention. https://www.cambridge.org/core/product/identifier/S0924933824000154/type/journal_articleadolescent depressioncognitive abilitiesdepressive severityhippocampal subfieldsprogressive abnormality |
| spellingShingle | Yixin Zhang Xuan Liu Ying Yang Yihao Zhang Qiang He Feiyu Xu Xinjuan Jin Junqi Gao Yuan Yao Dexin Yu Bernhard Hommel Xingxing Zhu Kangcheng Wang Wenxin Zhang Revealing complexity: segmentation of hippocampal subfields in adolescents with major depressive disorder reveals specific links to cognitive dysfunctions European Psychiatry adolescent depression cognitive abilities depressive severity hippocampal subfields progressive abnormality |
| title | Revealing complexity: segmentation of hippocampal subfields in adolescents with major depressive disorder reveals specific links to cognitive dysfunctions |
| title_full | Revealing complexity: segmentation of hippocampal subfields in adolescents with major depressive disorder reveals specific links to cognitive dysfunctions |
| title_fullStr | Revealing complexity: segmentation of hippocampal subfields in adolescents with major depressive disorder reveals specific links to cognitive dysfunctions |
| title_full_unstemmed | Revealing complexity: segmentation of hippocampal subfields in adolescents with major depressive disorder reveals specific links to cognitive dysfunctions |
| title_short | Revealing complexity: segmentation of hippocampal subfields in adolescents with major depressive disorder reveals specific links to cognitive dysfunctions |
| title_sort | revealing complexity segmentation of hippocampal subfields in adolescents with major depressive disorder reveals specific links to cognitive dysfunctions |
| topic | adolescent depression cognitive abilities depressive severity hippocampal subfields progressive abnormality |
| url | https://www.cambridge.org/core/product/identifier/S0924933824000154/type/journal_article |
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