Genome-wide DNA methylation analysis of Astragalus on the intervention of ID2 promoter via PI3K/Akt signaling pathway in peritoneal fibrosis

Genome-wide DNA methylation analysis of Astragalus on the intervention of ID2 promoter via PI3K/Akt signaling pathway in peritoneal fibrosis

Abstract Peritoneal dialysis (PD) is a successful renal replacement therapy for end-stage renal disease. Continuous infiltration of bioincompatible PD fluid causes mesothelial-mesenchymal transition (MMT) of peritoneal mesothelial cells (PMCs), leading to peritoneal fibrosis (PF). DNA methylation ha...

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Bibliographic Details
Main Authors: Manshu Yu, Junyi Zhao, Yun Shan, Huibo Dai, Lei Tang, Li Sheng, Lu Zhang, Meixiao Sheng
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Peritoneal fibrosis
Mesothelial-mesenchymal transition
Astragalus
DNA methylation
Inhibitor of DNA-binding 2
Online Access:https://doi.org/10.1038/s41598-025-96709-w
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