Transcriptomic and proteomic signatures of host NK cells delineate distinct immune states across tuberculosis infection statuses

Transcriptomic and proteomic signatures of host NK cells delineate distinct immune states across tuberculosis infection statuses

IntroductionAlthough natural killer (NK) cells play crucial roles in the immune response to Mycobacterium tuberculosis (M.tb) infection, systematic investigations delineating the immune characteristics of NK cells across the tuberculosis (TB) disease spectrum are scarce.MethodsThis multiomics study...

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Bibliographic Details
Main Authors: Han Zhang, Liguo Liu, Jie Hu, Xiaolin Wu, Jianhua Zheng, Henan Xin, Jiang Du, Jiarong Yang, Zizheng Lv, Zhuoran Wu, Lei Gao, Rongmei Liu, Haidan Sun, Xiaobing Zhang, Qi Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
RNA sequencing
liquid chromatography-tandem mass spectrometry
natural killer cells
CD56dim NK cell
CD56bright NK cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607770/full
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