Navigating challenges in pediatric trial conduct: integrating bayesian sequential design with semiparametric elicitation for handling primary and secondary endpoints

Navigating challenges in pediatric trial conduct: integrating bayesian sequential design with semiparametric elicitation for handling primary and secondary endpoints

Abstract Background This study presents a Bayesian Adaptive Semiparametric approach designed to address the challenges of pediatric randomized controlled trials (RCTs). The study focuses on efficiently handling primary and secondary endpoints, a critical aspect often overlooked in pediatric trials....

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Bibliographic Details
Main Authors: Danila Azzolina, Ileana Baldi, Silvia Bressan, Mohd Rashid Khan, Liviana Da Dalt, Dario Gregori, Paola Berchialla
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Medical Research Methodology
Subjects:
Pediatric trial
Semiparametric prior
Prior Elicitation
Multiple endpoints
Sequential design
Bayesian trial
Online Access:https://doi.org/10.1186/s12874-025-02484-7
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