Shanghai Preconception Cohort (SPCC) for the association of periconceptional parental key nutritional factors with health outcomes of children with congenital heart disease: a cohort profile
Purpose The Shanghai Preconception Cohort (SPCC) was initially established to investigate the associations of parental periconceptional nutritional factors with congenital heart disease (CHD) but has further analysed child growth and development and paediatric diseases.Participants Preparing-for-pre...
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BMJ Publishing Group
2019-11-01
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| author | Yuhuan Liu Lei Zhang Qing Liu Hong Zhu Ying Wang Hong Huang Min Jiang Yi Zhang Xiaojing Ma Dingmei Wang Yuang Jiang Ying Ye Mi Ji Yalan Dou Xiaotian Chen Mengru Li Wei Sheng Guoying Huang Weifen Luo Yin Ye Yumei Liu Gu Qing(s) Gu Qing(o) Linmei Zhu De’ai Hou Peiyu Sun Hongbing Wang Li Meng Zifen Dai Li fen Shufang Chen Zhenhua Tang Jiahao Wu Shuhua Wang Dan li Yu Ke Weiping Cao Baoren Zhang Nailing Wang Qiumin Xia Guoying Lao HongMei Jin Wenjuan Xie Pin Yi Weiming Gong JianXin Xu Yingying Qian Mingjie Luo Jingwei Xia Dongmei Chen Zhenyu Tang Xuejing Zhu Huiling Yang Xiaotian Li Zhiyong Wu Chuanmin Ying Shan Shi Yanquan Zhang Mingyi Yang Xiaohua Zhang Lin Guan Jinyu Xu Honglin Wang Fang Shen Wenying Li Xiaojing Teng Jinling Zhao Cuili Zhu Hongwei Chen Xiaoming Yuan Meihua Zhang Yaqiong Jin Qing Yang Min Feng Yan Wu Sa Guo Hongling Du Zhanyue Yi Renhua Shi Qinfen Su Yingying Lv Yun Sun Qiongpei Gu Xixia Pang Qingwu Zhang Songxiao Bai Baoqiao Qi |
| author_facet | Yuhuan Liu Lei Zhang Qing Liu Hong Zhu Ying Wang Hong Huang Min Jiang Yi Zhang Xiaojing Ma Dingmei Wang Yuang Jiang Ying Ye Mi Ji Yalan Dou Xiaotian Chen Mengru Li Wei Sheng Guoying Huang Weifen Luo Yin Ye Yumei Liu Gu Qing(s) Gu Qing(o) Linmei Zhu De’ai Hou Peiyu Sun Hongbing Wang Li Meng Zifen Dai Li fen Shufang Chen Zhenhua Tang Jiahao Wu Shuhua Wang Dan li Yu Ke Weiping Cao Baoren Zhang Nailing Wang Qiumin Xia Guoying Lao HongMei Jin Wenjuan Xie Pin Yi Weiming Gong JianXin Xu Yingying Qian Mingjie Luo Jingwei Xia Dongmei Chen Zhenyu Tang Xuejing Zhu Huiling Yang Xiaotian Li Zhiyong Wu Chuanmin Ying Shan Shi Yanquan Zhang Mingyi Yang Xiaohua Zhang Lin Guan Jinyu Xu Honglin Wang Fang Shen Wenying Li Xiaojing Teng Jinling Zhao Cuili Zhu Hongwei Chen Xiaoming Yuan Meihua Zhang Yaqiong Jin Qing Yang Min Feng Yan Wu Sa Guo Hongling Du Zhanyue Yi Renhua Shi Qinfen Su Yingying Lv Yun Sun Qiongpei Gu Xixia Pang Qingwu Zhang Songxiao Bai Baoqiao Qi |
| author_sort | Yuhuan Liu |
| collection | DOAJ |
| description | Purpose The Shanghai Preconception Cohort (SPCC) was initially established to investigate the associations of parental periconceptional nutritional factors with congenital heart disease (CHD) but has further analysed child growth and development and paediatric diseases.Participants Preparing-for-pregnancy couples who presented at Shanghai preconception examination clinics and early-pregnancy women before 14 gestational weeks were enrolled to comprise the periconceptional baseline study population. General characteristics, routine clinical data and consumption of diet supplements, such as folic acid and multivitamins, were collected. Blood samples were obtained at preconception and early, middle and late gestations using standard procedures. Multiple nutritional factors, including folate, homocysteine, vitamin A, vitamin D, vitamin E and metals, in the blood samples of participants selected using a case–control design were examined. Genomic DNA was extracted.Findings to date The baseline population included 8045 preconception couples, 3054 single women and 15 615 early-pregnancy women. Data from 12 402 births were collected, and follow-up of the cohort for other outcomes is ongoing. Currently, 151 cases of CHD were identified after birth. The pilot analysis in a small subgroup showed that approximately 20.0% of preconception women and 44.9% of early-pregnancy women had red blood cell (RBC) folate levels that met the international recommendation for preventing neural tube defects.Future plans Once a sufficient number of CHD cases are achieved, we will investigate the quantitative association of preconception RBC folate levels with CHD using a nested case–control design. The SPCC will be followed up for 18 years to investigate extensive outcomes of growth, development, obesity, and common and rare diseases during childhood and adolescence according to our plan. Blood nutritional factors will be examined in participants selected for specific aims. The SPCC will also allow for prospective cohort studies on extensive research questions.Trial registration number NCT 02737644 |
| format | Article |
| id | doaj-art-16b3690126444cb9afc6f46d23ac7d3b |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-16b3690126444cb9afc6f46d23ac7d3b2024-11-30T05:35:08ZengBMJ Publishing GroupBMJ Open2044-60552019-11-0191110.1136/bmjopen-2019-031076Shanghai Preconception Cohort (SPCC) for the association of periconceptional parental key nutritional factors with health outcomes of children with congenital heart disease: a cohort profileYuhuan LiuLei Zhang0Qing Liu1Hong Zhu2Ying Wang3Hong Huang4Min Jiang5Yi Zhang6Xiaojing Ma7Dingmei Wang8Yuang Jiang9Ying Ye10Mi Ji11Yalan Dou12Xiaotian Chen13Mengru Li14Wei Sheng15Guoying Huang16Weifen LuoYin YeYumei LiuGu Qing(s)Gu Qing(o)Linmei ZhuDe’ai HouPeiyu SunHongbing WangLi MengZifen DaiLi fen17Shufang ChenZhenhua TangJiahao Wu18Shuhua Wang19Dan li20Yu KeWeiping Cao21Baoren ZhangNailing WangQiumin XiaGuoying LaoHongMei JinWenjuan XiePin YiWeiming Gong22JianXin XuYingying QianMingjie LuoJingwei Xia23Dongmei Chen24Zhenyu Tang25Xuejing ZhuHuiling Yang26Xiaotian Li27Zhiyong Wu28Chuanmin YingShan ShiYanquan ZhangMingyi YangXiaohua Zhang29Lin Guan30Jinyu XuHonglin Wang31Fang Shen32Wenying LiXiaojing TengJinling ZhaoCuili ZhuHongwei Chen33Xiaoming YuanMeihua ZhangYaqiong JinQing Yang34Min Feng35Yan Wu36Sa GuoHongling DuZhanyue YiRenhua ShiQinfen SuYingying LvYun Sun37Qiongpei GuXixia PangQingwu ZhangSongxiao BaiBaoqiao QiClinical Medical Research Center, Children’s Hospital of Nanjing Medical University, Nanjing, People`s Republic of ChinaDepartment of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, SwedenDepartment of Oncology, Xiangya Hospital Central South University, Changsha, Hunan, China1 Australian Institute of Health Innovation, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, AustraliaDepartment of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing, ChinaDepartment of Gastroenterology, The First Hospital of China Medical University, Shenyang city, Liaoning province, ChinaDepartment of Psychiatry, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA12 Cardiovascular Center, Children`s Hospital of Fudan University, National Children`s Medical Center, Shanghai, ChinaChildren’s Hospital of Fudan University, Shanghai, ChinaChildren’s Hospital of Fudan University, Shanghai, China4 Anesthesiology and Perioperative Care Service, VA Palo Alto Health Care System, Palo Alto, California, USAChildren’s Hospital of Fudan University, Shanghai, ChinaDepartment of Clinical Epidemiology, Children`s Hospital of Fudan University, National Children`s Medical Center, Shanghai, ChinaDepartment of Clinical Nutrition, Nanjing Drum Tower Hospital, Nanjing, ChinaChildren’s Hospital of Fudan University, Shanghai, ChinaChildren’s Hospital of Fudan University, Shanghai, China12 Cardiovascular Center, Children`s Hospital of Fudan University, National Children`s Medical Center, Shanghai, China6The Second Xiangya Hospital of Central South University, Changsha, ChinaInternational Peace Maternity and Child Health Hospital, Shanghai, China1 Hematology and Medical Oncology, Emory University Winship Cancer Institute, Atlanta, Georgia, USADepartment of Neurology, Keshiketeng Banner Traditional Chinese Medicine Mongolian Medicine Hospitalorem Ipsum, Keshiketeng, Inner Mongolia, China1 Division of STD Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USAInstitute of Sexually Transmitted Disease, Shanghai Skin Disease Hospital,School of Medicine, Tongji University, Shanghai,200443, ChinaShanghai Huangpu District Maternal and Child Health Care Institute, Shanghai, ChinaDepartment of Neonatology, Quanzhou Maternity and Children’s Hospital, Quanzhou, Fujian Province, ChinaDepartment of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China3 Eastern-fusion Master Studio of Hezhou, Hezhou, China3 Department of Obstetrics, Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, ChinaDepartment of Cardiology, Fujian Provincial Hospital, Provincial College of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Cardiology, Chengdu University of Traditional Chinese Medicine Affiliated Fifth Peoples Hospital, Chengdu, Sichuan, China1 Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaTianjin Key Laboratory of Brain Science and Neuroengineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, People`s Republic of ChinaNeurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, ChinaDepartment of Nephrology, People`s Liberation Army Strategic Support Force Medical Center, Beijing, China1 Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou, China2 Department of Gynecology, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, ChinaPurpose The Shanghai Preconception Cohort (SPCC) was initially established to investigate the associations of parental periconceptional nutritional factors with congenital heart disease (CHD) but has further analysed child growth and development and paediatric diseases.Participants Preparing-for-pregnancy couples who presented at Shanghai preconception examination clinics and early-pregnancy women before 14 gestational weeks were enrolled to comprise the periconceptional baseline study population. General characteristics, routine clinical data and consumption of diet supplements, such as folic acid and multivitamins, were collected. Blood samples were obtained at preconception and early, middle and late gestations using standard procedures. Multiple nutritional factors, including folate, homocysteine, vitamin A, vitamin D, vitamin E and metals, in the blood samples of participants selected using a case–control design were examined. Genomic DNA was extracted.Findings to date The baseline population included 8045 preconception couples, 3054 single women and 15 615 early-pregnancy women. Data from 12 402 births were collected, and follow-up of the cohort for other outcomes is ongoing. Currently, 151 cases of CHD were identified after birth. The pilot analysis in a small subgroup showed that approximately 20.0% of preconception women and 44.9% of early-pregnancy women had red blood cell (RBC) folate levels that met the international recommendation for preventing neural tube defects.Future plans Once a sufficient number of CHD cases are achieved, we will investigate the quantitative association of preconception RBC folate levels with CHD using a nested case–control design. The SPCC will be followed up for 18 years to investigate extensive outcomes of growth, development, obesity, and common and rare diseases during childhood and adolescence according to our plan. Blood nutritional factors will be examined in participants selected for specific aims. The SPCC will also allow for prospective cohort studies on extensive research questions.Trial registration number NCT 02737644https://bmjopen.bmj.com/content/9/11/e031076.full |
| spellingShingle | Yuhuan Liu Lei Zhang Qing Liu Hong Zhu Ying Wang Hong Huang Min Jiang Yi Zhang Xiaojing Ma Dingmei Wang Yuang Jiang Ying Ye Mi Ji Yalan Dou Xiaotian Chen Mengru Li Wei Sheng Guoying Huang Weifen Luo Yin Ye Yumei Liu Gu Qing(s) Gu Qing(o) Linmei Zhu De’ai Hou Peiyu Sun Hongbing Wang Li Meng Zifen Dai Li fen Shufang Chen Zhenhua Tang Jiahao Wu Shuhua Wang Dan li Yu Ke Weiping Cao Baoren Zhang Nailing Wang Qiumin Xia Guoying Lao HongMei Jin Wenjuan Xie Pin Yi Weiming Gong JianXin Xu Yingying Qian Mingjie Luo Jingwei Xia Dongmei Chen Zhenyu Tang Xuejing Zhu Huiling Yang Xiaotian Li Zhiyong Wu Chuanmin Ying Shan Shi Yanquan Zhang Mingyi Yang Xiaohua Zhang Lin Guan Jinyu Xu Honglin Wang Fang Shen Wenying Li Xiaojing Teng Jinling Zhao Cuili Zhu Hongwei Chen Xiaoming Yuan Meihua Zhang Yaqiong Jin Qing Yang Min Feng Yan Wu Sa Guo Hongling Du Zhanyue Yi Renhua Shi Qinfen Su Yingying Lv Yun Sun Qiongpei Gu Xixia Pang Qingwu Zhang Songxiao Bai Baoqiao Qi Shanghai Preconception Cohort (SPCC) for the association of periconceptional parental key nutritional factors with health outcomes of children with congenital heart disease: a cohort profile BMJ Open |
| title | Shanghai Preconception Cohort (SPCC) for the association of periconceptional parental key nutritional factors with health outcomes of children with congenital heart disease: a cohort profile |
| title_full | Shanghai Preconception Cohort (SPCC) for the association of periconceptional parental key nutritional factors with health outcomes of children with congenital heart disease: a cohort profile |
| title_fullStr | Shanghai Preconception Cohort (SPCC) for the association of periconceptional parental key nutritional factors with health outcomes of children with congenital heart disease: a cohort profile |
| title_full_unstemmed | Shanghai Preconception Cohort (SPCC) for the association of periconceptional parental key nutritional factors with health outcomes of children with congenital heart disease: a cohort profile |
| title_short | Shanghai Preconception Cohort (SPCC) for the association of periconceptional parental key nutritional factors with health outcomes of children with congenital heart disease: a cohort profile |
| title_sort | shanghai preconception cohort spcc for the association of periconceptional parental key nutritional factors with health outcomes of children with congenital heart disease a cohort profile |
| url | https://bmjopen.bmj.com/content/9/11/e031076.full |
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shanghaipreconceptioncohortspccfortheassociationofpericonceptionalparentalkeynutritionalfactorswithhealthoutcomesofchildrenwithcongenitalheartdiseaseacohortprofile AT yunsun shanghaipreconceptioncohortspccfortheassociationofpericonceptionalparentalkeynutritionalfactorswithhealthoutcomesofchildrenwithcongenitalheartdiseaseacohortprofile AT qiongpeigu shanghaipreconceptioncohortspccfortheassociationofpericonceptionalparentalkeynutritionalfactorswithhealthoutcomesofchildrenwithcongenitalheartdiseaseacohortprofile AT xixiapang shanghaipreconceptioncohortspccfortheassociationofpericonceptionalparentalkeynutritionalfactorswithhealthoutcomesofchildrenwithcongenitalheartdiseaseacohortprofile AT qingwuzhang shanghaipreconceptioncohortspccfortheassociationofpericonceptionalparentalkeynutritionalfactorswithhealthoutcomesofchildrenwithcongenitalheartdiseaseacohortprofile AT songxiaobai shanghaipreconceptioncohortspccfortheassociationofpericonceptionalparentalkeynutritionalfactorswithhealthoutcomesofchildrenwithcongenitalheartdiseaseacohortprofile AT baoqiaoqi shanghaipreconceptioncohortspccfortheassociationofpericonceptionalparentalkeynutritionalfactorswithhealthoutcomesofchildrenwithcongenitalheartdiseaseacohortprofile |