The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2

The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2

Aim. To reveal the role of inflammatory markers (homocystein (HC), interleukin-6 (IL-6)), components of hemostatic mechanism ofcoagulation in the development of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Materials and methods. A total of 240 patients with T2DM and...

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Main Authors: Yulia Valer'evna Khasanova, Alsu Asatovna Nelaeva, Anna Borisovna Galkina, Irina Vasil'evna Medvedeva
Format: Article
Language:English
Published: Endocrinology Research Centre 2012-03-01
Series:Сахарный диабет
Subjects:
diabetes mellitus type 2
diabetic nephropathy
chronic kidney disease
coagulopathy
iterleikin-6
homocystein
inflammation
Online Access:https://www.dia-endojournals.ru/jour/article/view/5976
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Summary:Aim. To reveal the role of inflammatory markers (homocystein (HC), interleukin-6 (IL-6)), components of hemostatic mechanism ofcoagulation in the development of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Materials and methods. A total of 240 patients with T2DM and DN were examined. Results. Negative correlation between HC level and glomerular filtration rate (GFR) (r= -0,38) and positive correlation between IL-6and fibrinogen (r=0,55) were observed. Conclusion. Inflammation and changes in mechanism of coagulation have influence on development and progression of DN in patientswith T2DM.
ISSN:2072-0351
2072-0378

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