The Association Between Cytomegalovirus Infection and Kidney Damage in the Liver Transplant Setting
Introduction: The development of chronic kidney disease (CKD) is a common and significant complication, contributing to morbidity after liver transplantation (LT). Cytomegalovirus (CMV) infection is common in the overall population, and relevant reinfection after LT may occur. CMV-associated kidney...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/16/12/1830 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846102399189516288 |
|---|---|
| author | Ramin Raul Ossami Saidy Franziska Eurich Brigitta Globke Wenzel Schöning Robert Öllinger Nathanael Raschzok Johann Pratschke Dennis Eurich Luca Dittrich Eva Maria Dobrindt |
| author_facet | Ramin Raul Ossami Saidy Franziska Eurich Brigitta Globke Wenzel Schöning Robert Öllinger Nathanael Raschzok Johann Pratschke Dennis Eurich Luca Dittrich Eva Maria Dobrindt |
| author_sort | Ramin Raul Ossami Saidy |
| collection | DOAJ |
| description | Introduction: The development of chronic kidney disease (CKD) is a common and significant complication, contributing to morbidity after liver transplantation (LT). Cytomegalovirus (CMV) infection is common in the overall population, and relevant reinfection after LT may occur. CMV-associated kidney damage has been discussed, but the clinical significance on CKD development after LT remains unclear. Methods: A total of 745 patients who underwent LT between 2006 and 2017 were included in this retrospective analysis. Clinical data, as well as laboratory parameters, were analyzed. Univariate and multivariate analysis were performed. Results: The univariate analysis revealed significantly impaired estimated glomerular filtration rates (eGFRs) in patients with histories of CMV infection (81.4 (8–137) mL/min vs. 90.0 (5–147) mL/min; <i>p</i> = 0.004). This effect was confirmed in the multivariate analysis. Post-LT, eGFR was impaired in patients with CMV (re)infection at 6, 12, 36, and 60 months, 10 years, and 15 years after LT. Immunosuppressive levels were comparable between groups. Overall survival was negatively affected by CMV infection (<i>p</i> = 0.001). Discussion: A clinically significant detrimental impact of CMV infection on renal function was observed, that could individualize clinical risk evaluation prior and after LT further. However, the pathophysiological mechanisms behind this observation are not yet understood. |
| format | Article |
| id | doaj-art-16a1a4df9a3b40388bc28d6e91f3ad3a |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-16a1a4df9a3b40388bc28d6e91f3ad3a2024-12-27T14:58:58ZengMDPI AGViruses1999-49152024-11-011612183010.3390/v16121830The Association Between Cytomegalovirus Infection and Kidney Damage in the Liver Transplant SettingRamin Raul Ossami Saidy0Franziska Eurich1Brigitta Globke2Wenzel Schöning3Robert Öllinger4Nathanael Raschzok5Johann Pratschke6Dennis Eurich7Luca Dittrich8Eva Maria Dobrindt9Department of Surgery, Campus Virchow Klinikum and Campus Charité Mitte, Charité–Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow Klinikum and Campus Charité Mitte, Charité–Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow Klinikum and Campus Charité Mitte, Charité–Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow Klinikum and Campus Charité Mitte, Charité–Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow Klinikum and Campus Charité Mitte, Charité–Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow Klinikum and Campus Charité Mitte, Charité–Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow Klinikum and Campus Charité Mitte, Charité–Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow Klinikum and Campus Charité Mitte, Charité–Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow Klinikum and Campus Charité Mitte, Charité–Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Surgery, Campus Virchow Klinikum and Campus Charité Mitte, Charité–Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyIntroduction: The development of chronic kidney disease (CKD) is a common and significant complication, contributing to morbidity after liver transplantation (LT). Cytomegalovirus (CMV) infection is common in the overall population, and relevant reinfection after LT may occur. CMV-associated kidney damage has been discussed, but the clinical significance on CKD development after LT remains unclear. Methods: A total of 745 patients who underwent LT between 2006 and 2017 were included in this retrospective analysis. Clinical data, as well as laboratory parameters, were analyzed. Univariate and multivariate analysis were performed. Results: The univariate analysis revealed significantly impaired estimated glomerular filtration rates (eGFRs) in patients with histories of CMV infection (81.4 (8–137) mL/min vs. 90.0 (5–147) mL/min; <i>p</i> = 0.004). This effect was confirmed in the multivariate analysis. Post-LT, eGFR was impaired in patients with CMV (re)infection at 6, 12, 36, and 60 months, 10 years, and 15 years after LT. Immunosuppressive levels were comparable between groups. Overall survival was negatively affected by CMV infection (<i>p</i> = 0.001). Discussion: A clinically significant detrimental impact of CMV infection on renal function was observed, that could individualize clinical risk evaluation prior and after LT further. However, the pathophysiological mechanisms behind this observation are not yet understood.https://www.mdpi.com/1999-4915/16/12/1830liver transplantationcytomegaloviruschronic kidney diseaseimmunosuppression |
| spellingShingle | Ramin Raul Ossami Saidy Franziska Eurich Brigitta Globke Wenzel Schöning Robert Öllinger Nathanael Raschzok Johann Pratschke Dennis Eurich Luca Dittrich Eva Maria Dobrindt The Association Between Cytomegalovirus Infection and Kidney Damage in the Liver Transplant Setting Viruses liver transplantation cytomegalovirus chronic kidney disease immunosuppression |
| title | The Association Between Cytomegalovirus Infection and Kidney Damage in the Liver Transplant Setting |
| title_full | The Association Between Cytomegalovirus Infection and Kidney Damage in the Liver Transplant Setting |
| title_fullStr | The Association Between Cytomegalovirus Infection and Kidney Damage in the Liver Transplant Setting |
| title_full_unstemmed | The Association Between Cytomegalovirus Infection and Kidney Damage in the Liver Transplant Setting |
| title_short | The Association Between Cytomegalovirus Infection and Kidney Damage in the Liver Transplant Setting |
| title_sort | association between cytomegalovirus infection and kidney damage in the liver transplant setting |
| topic | liver transplantation cytomegalovirus chronic kidney disease immunosuppression |
| url | https://www.mdpi.com/1999-4915/16/12/1830 |
| work_keys_str_mv | AT raminraulossamisaidy theassociationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT franziskaeurich theassociationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT brigittaglobke theassociationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT wenzelschoning theassociationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT robertollinger theassociationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT nathanaelraschzok theassociationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT johannpratschke theassociationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT denniseurich theassociationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT lucadittrich theassociationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT evamariadobrindt theassociationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT raminraulossamisaidy associationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT franziskaeurich associationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT brigittaglobke associationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT wenzelschoning associationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT robertollinger associationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT nathanaelraschzok associationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT johannpratschke associationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT denniseurich associationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT lucadittrich associationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting AT evamariadobrindt associationbetweencytomegalovirusinfectionandkidneydamageinthelivertransplantsetting |