The hypoglycemic effect of ginsenoside Rd in db/db mice is mediated by increased insulin sensitivity and suppressed hepatic gluconeogenesis
Ginsenoside Rd, one of the major components entering into the circulation from ginseng, is beneficial to health; however, its role and mechanism in improving T2DM require further exploration. In the current study, we explored the hypoglycemic effects of Rd in diabetic db/db mice and examined the und...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-11-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624004778 |
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| author | Zaiqi Han Haihui Yu Zhe Liu Yue Zhong Sheng Chang Xin Sun Lu Yao |
| author_facet | Zaiqi Han Haihui Yu Zhe Liu Yue Zhong Sheng Chang Xin Sun Lu Yao |
| author_sort | Zaiqi Han |
| collection | DOAJ |
| description | Ginsenoside Rd, one of the major components entering into the circulation from ginseng, is beneficial to health; however, its role and mechanism in improving T2DM require further exploration. In the current study, we explored the hypoglycemic effects of Rd in diabetic db/db mice and examined the underlying mechanisms. The results disclosed that after Rd treatment for four weeks, hyperglycemia, insulin resistance, and pyruvate intolerance were improved; moreover, hepatic steatosis was ameliorated. Additionally, Rd increased the phosphorylated Akt ratio in insulin-regulated peripheral tissues and decreased hepatic gluconeogenic gene expression. In vitro experimental results demonstrated that Rd decreased cellular glucose output from insulin-resistant mouse and human hepatocytes. Rd reduced gluconeogenic gene expression through inhibiting Foxo1 transcriptional activity. Taken together, our results suggest that Rd mitigates hyperglycemia in db/db mice by enhancing insulin sensitivity and diminishing hepatic gluconeogenesis, thus providing a theoretical principle for applying ginseng and ginsenoside Rd on curing T2DM. |
| format | Article |
| id | doaj-art-1680836eed064b05af5db0f34f03e92b |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-1680836eed064b05af5db0f34f03e92b2024-11-16T05:10:35ZengElsevierJournal of Functional Foods1756-46462024-11-01122106475The hypoglycemic effect of ginsenoside Rd in db/db mice is mediated by increased insulin sensitivity and suppressed hepatic gluconeogenesisZaiqi Han0Haihui Yu1Zhe Liu2Yue Zhong3Sheng Chang4Xin Sun5Lu Yao6College of Pharmacy, Jilin Medical University, Jilin City, Jilin Province, ChinaCollege of Clinical Medicine, Jilin Medical University, Jilin City, Jilin Province, ChinaCollege of Pharmacy, Jilin Medical University, Jilin City, Jilin Province, ChinaCollege of Management, Jilin Medical University, Jilin City, Jilin Province, ChinaCollege of Pharmacy, Jilin Medical University, Jilin City, Jilin Province, ChinaCollege of Pharmacy, Jilin Medical University, Jilin City, Jilin Province, ChinaCollege of Pharmacy, Jilin Medical University, Jilin City, Jilin Province, China; Corresponding author at: College of Pharmacy, Jilin Medical University, No.5, Jilin Street, Jilin 132013, China.Ginsenoside Rd, one of the major components entering into the circulation from ginseng, is beneficial to health; however, its role and mechanism in improving T2DM require further exploration. In the current study, we explored the hypoglycemic effects of Rd in diabetic db/db mice and examined the underlying mechanisms. The results disclosed that after Rd treatment for four weeks, hyperglycemia, insulin resistance, and pyruvate intolerance were improved; moreover, hepatic steatosis was ameliorated. Additionally, Rd increased the phosphorylated Akt ratio in insulin-regulated peripheral tissues and decreased hepatic gluconeogenic gene expression. In vitro experimental results demonstrated that Rd decreased cellular glucose output from insulin-resistant mouse and human hepatocytes. Rd reduced gluconeogenic gene expression through inhibiting Foxo1 transcriptional activity. Taken together, our results suggest that Rd mitigates hyperglycemia in db/db mice by enhancing insulin sensitivity and diminishing hepatic gluconeogenesis, thus providing a theoretical principle for applying ginseng and ginsenoside Rd on curing T2DM.http://www.sciencedirect.com/science/article/pii/S1756464624004778ginsenoside RdInsulin sensitivityGluconeogenesisHepatocyteFoxo1 |
| spellingShingle | Zaiqi Han Haihui Yu Zhe Liu Yue Zhong Sheng Chang Xin Sun Lu Yao The hypoglycemic effect of ginsenoside Rd in db/db mice is mediated by increased insulin sensitivity and suppressed hepatic gluconeogenesis Journal of Functional Foods ginsenoside Rd Insulin sensitivity Gluconeogenesis Hepatocyte Foxo1 |
| title | The hypoglycemic effect of ginsenoside Rd in db/db mice is mediated by increased insulin sensitivity and suppressed hepatic gluconeogenesis |
| title_full | The hypoglycemic effect of ginsenoside Rd in db/db mice is mediated by increased insulin sensitivity and suppressed hepatic gluconeogenesis |
| title_fullStr | The hypoglycemic effect of ginsenoside Rd in db/db mice is mediated by increased insulin sensitivity and suppressed hepatic gluconeogenesis |
| title_full_unstemmed | The hypoglycemic effect of ginsenoside Rd in db/db mice is mediated by increased insulin sensitivity and suppressed hepatic gluconeogenesis |
| title_short | The hypoglycemic effect of ginsenoside Rd in db/db mice is mediated by increased insulin sensitivity and suppressed hepatic gluconeogenesis |
| title_sort | hypoglycemic effect of ginsenoside rd in db db mice is mediated by increased insulin sensitivity and suppressed hepatic gluconeogenesis |
| topic | ginsenoside Rd Insulin sensitivity Gluconeogenesis Hepatocyte Foxo1 |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624004778 |
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