Clinicopathological risk factors of oral second primary tumours
Background: Oral second primary tumours (SPTs) have a poor prognosis due to late-stage diagnosis. This study evaluates the demographic and clinicopathological risk predictors of SPTs. Methods: Patients with oral squamous cell carcinoma, carcinoma in situ, or severe dysplasia were accrued into the Or...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-09-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024004849 |
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| author | Jelena Karan Miriam P. Rosin Lewei Zhang Denise M. Laronde |
| author_facet | Jelena Karan Miriam P. Rosin Lewei Zhang Denise M. Laronde |
| author_sort | Jelena Karan |
| collection | DOAJ |
| description | Background: Oral second primary tumours (SPTs) have a poor prognosis due to late-stage diagnosis. This study evaluates the demographic and clinicopathological risk predictors of SPTs. Methods: Patients with oral squamous cell carcinoma, carcinoma in situ, or severe dysplasia were accrued into the Oral Cancer Prediction Longitudinal study within one year post-curative treatment. Data on demographics, risk habits, and primary tumour characteristics were collected. Clinical follow-up included assessing the presence of second oral premalignant lesions (SOPLs), clinicopathological features, and the results from toluidine blue staining and fluorescence visualization. Results: Among 296 patients, 23 (8 %) developed SPTs. Older age at primary cancer diagnosis (P = 0.008) and a history of chewing tobacco or betel nut (P = 0.043) increased the risk of SPTs. Patients with primary tumours located at low-risk sites had an increased risk of SPTs (P = 0.004), which often presented at high-risk sites. The presence of SOPLs (P < 0.001), and multiple lesions (P = 0.017) significantly increased the risk of SPTs. Positive toluidine blue staining indicated a trend toward higher risk of SPTs, whereas fluorescence visualization did not. The median time to SPT diagnosis was 3.25 years post-treatment. Conclusions: Identifying second or multiple oral premalignant lesions is critical for predicting the risk of SPTs regardless of their clinical or histological characteristics. Routine biopsy of these lesions should be prioritized to ensure timely diagnosis. Incorporating these risk predictors into clinical follow-up can enhance early cancer detection and improve patient outcomes. |
| format | Article |
| id | doaj-art-1678fc5719fc4d3ba0d4aa29f36d0c86 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-1678fc5719fc4d3ba0d4aa29f36d0c862025-01-09T06:17:00ZengElsevierOral Oncology Reports2772-90602024-09-0111100638Clinicopathological risk factors of oral second primary tumoursJelena Karan0Miriam P. Rosin1Lewei Zhang2Denise M. Laronde3Faculty of Dentistry, University of British Columbia, 2199 Wesbrook Mall, Vancouver, BC, Canada, V6T1Z3; Corresponding author.Cancer Control Research, British Columbia Cancer Agency, 675 W10th Avenue, Vancouver, BC, Canada, V5Z 1L3; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, 8888 University Dr, Burnaby, BC, Canada, V5A 1S6Faculty of Dentistry, University of British Columbia, 2199 Wesbrook Mall, Vancouver, BC, Canada, V6T1Z3Faculty of Dentistry, University of British Columbia, 2199 Wesbrook Mall, Vancouver, BC, Canada, V6T1Z3; Cancer Control Research, British Columbia Cancer Agency, 675 W10th Avenue, Vancouver, BC, Canada, V5Z 1L3Background: Oral second primary tumours (SPTs) have a poor prognosis due to late-stage diagnosis. This study evaluates the demographic and clinicopathological risk predictors of SPTs. Methods: Patients with oral squamous cell carcinoma, carcinoma in situ, or severe dysplasia were accrued into the Oral Cancer Prediction Longitudinal study within one year post-curative treatment. Data on demographics, risk habits, and primary tumour characteristics were collected. Clinical follow-up included assessing the presence of second oral premalignant lesions (SOPLs), clinicopathological features, and the results from toluidine blue staining and fluorescence visualization. Results: Among 296 patients, 23 (8 %) developed SPTs. Older age at primary cancer diagnosis (P = 0.008) and a history of chewing tobacco or betel nut (P = 0.043) increased the risk of SPTs. Patients with primary tumours located at low-risk sites had an increased risk of SPTs (P = 0.004), which often presented at high-risk sites. The presence of SOPLs (P < 0.001), and multiple lesions (P = 0.017) significantly increased the risk of SPTs. Positive toluidine blue staining indicated a trend toward higher risk of SPTs, whereas fluorescence visualization did not. The median time to SPT diagnosis was 3.25 years post-treatment. Conclusions: Identifying second or multiple oral premalignant lesions is critical for predicting the risk of SPTs regardless of their clinical or histological characteristics. Routine biopsy of these lesions should be prioritized to ensure timely diagnosis. Incorporating these risk predictors into clinical follow-up can enhance early cancer detection and improve patient outcomes.http://www.sciencedirect.com/science/article/pii/S2772906024004849Oral cancerHead and neck cancerSquamous cell carcinomaSecond primary cancerRisk factorsTobacco use |
| spellingShingle | Jelena Karan Miriam P. Rosin Lewei Zhang Denise M. Laronde Clinicopathological risk factors of oral second primary tumours Oral Oncology Reports Oral cancer Head and neck cancer Squamous cell carcinoma Second primary cancer Risk factors Tobacco use |
| title | Clinicopathological risk factors of oral second primary tumours |
| title_full | Clinicopathological risk factors of oral second primary tumours |
| title_fullStr | Clinicopathological risk factors of oral second primary tumours |
| title_full_unstemmed | Clinicopathological risk factors of oral second primary tumours |
| title_short | Clinicopathological risk factors of oral second primary tumours |
| title_sort | clinicopathological risk factors of oral second primary tumours |
| topic | Oral cancer Head and neck cancer Squamous cell carcinoma Second primary cancer Risk factors Tobacco use |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024004849 |
| work_keys_str_mv | AT jelenakaran clinicopathologicalriskfactorsoforalsecondprimarytumours AT miriamprosin clinicopathologicalriskfactorsoforalsecondprimarytumours AT leweizhang clinicopathologicalriskfactorsoforalsecondprimarytumours AT denisemlaronde clinicopathologicalriskfactorsoforalsecondprimarytumours |