Asthma amplifies dementia risk: Evidence from CSF biomarkers and cognitive decline
Abstract Introduction Evidence from epidemiology, neuroimaging, and animal models indicates that asthma adversely affects the brain, but the nature and extent of neuropathophysiological impact remain unclear. Methods We tested the hypothesis that asthma is a risk factor for dementia by comparing cog...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
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| Online Access: | https://doi.org/10.1002/trc2.12315 |
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| author | Ajay Kumar Nair Carol A. Van Hulle Barbara B. Bendlin Henrik Zetterberg Kaj Blennow Norbert Wild Gwendlyn Kollmorgen Ivonne Suridjan William W. Busse Melissa A. Rosenkranz |
| author_facet | Ajay Kumar Nair Carol A. Van Hulle Barbara B. Bendlin Henrik Zetterberg Kaj Blennow Norbert Wild Gwendlyn Kollmorgen Ivonne Suridjan William W. Busse Melissa A. Rosenkranz |
| author_sort | Ajay Kumar Nair |
| collection | DOAJ |
| description | Abstract Introduction Evidence from epidemiology, neuroimaging, and animal models indicates that asthma adversely affects the brain, but the nature and extent of neuropathophysiological impact remain unclear. Methods We tested the hypothesis that asthma is a risk factor for dementia by comparing cognitive performance and cerebrospinal fluid biomarkers of glial activation/neuroinflammation, neurodegeneration, and Alzheimer's disease (AD) pathology in 60 participants with asthma to 315 non‐asthma age‐matched control participants (45–93 years), in a sample enriched for AD risk. Results Participants with severe asthma had higher neurogranin concentrations compared to controls and those with mild asthma. Positive relationships between cardiovascular risk and concentrations of neurogranin and α‐synuclein were amplified in severe asthma. Severe asthma also amplified the deleterious associations that apolipoprotein E ε4 carrier status, cardiovascular risk, and phosphorylated tau181/amyloid beta42 have with rate of cognitive decline. Discussion Our data suggest that severe asthma is associated with synaptic degeneration and may compound risk for dementia posed by cardiovascular disease and genetic predisposition. Highlights Those with severe asthma showed evidence of higher dementia risk than controls evidenced by: higher levels of the synaptic degeneration biomarker neurogranin regardless of cognitive status, cardiovascular or genetic risk, and controlling for demographics. steeper increase in levels of synaptic degeneration biomarkers neurogranin and α‐synuclein with increasing cardiovascular risk. accelerated cognitive decline with higher cardiovascular risk, genetic predisposition, or pathological tau. |
| format | Article |
| id | doaj-art-164f6fd25a6844169d1b1d50b57b1855 |
| institution | Kabale University |
| issn | 2352-8737 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj-art-164f6fd25a6844169d1b1d50b57b18552024-12-03T12:37:31ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372022-01-0181n/an/a10.1002/trc2.12315Asthma amplifies dementia risk: Evidence from CSF biomarkers and cognitive declineAjay Kumar Nair0Carol A. Van Hulle1Barbara B. Bendlin2Henrik Zetterberg3Kaj Blennow4Norbert Wild5Gwendlyn Kollmorgen6Ivonne Suridjan7William W. Busse8Melissa A. Rosenkranz9Center for Healthy Minds University of Wisconsin‐Madison Madison Wisconsin USAWisconsin Alzheimer's Disease Research Center School of Medicine and Public Health University of Wisconsin‐Madison Madison Wisconsin USAWisconsin Alzheimer's Disease Research Center School of Medicine and Public Health University of Wisconsin‐Madison Madison Wisconsin USADepartment of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology The Sahlgrenska Academy at The University of Gothenburg Mölndal SwedenDepartment of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology The Sahlgrenska Academy at The University of Gothenburg Mölndal SwedenRoche Diagnostics GmbH Penzberg GermanyRoche Diagnostics GmbH Penzberg GermanyRoche Diagnostics International Ltd. Rotkreuz SwitzerlandDepartment of Medicine School of Medicine and Public Health University of Wisconsin‐Madison Madison Wisconsin USACenter for Healthy Minds University of Wisconsin‐Madison Madison Wisconsin USAAbstract Introduction Evidence from epidemiology, neuroimaging, and animal models indicates that asthma adversely affects the brain, but the nature and extent of neuropathophysiological impact remain unclear. Methods We tested the hypothesis that asthma is a risk factor for dementia by comparing cognitive performance and cerebrospinal fluid biomarkers of glial activation/neuroinflammation, neurodegeneration, and Alzheimer's disease (AD) pathology in 60 participants with asthma to 315 non‐asthma age‐matched control participants (45–93 years), in a sample enriched for AD risk. Results Participants with severe asthma had higher neurogranin concentrations compared to controls and those with mild asthma. Positive relationships between cardiovascular risk and concentrations of neurogranin and α‐synuclein were amplified in severe asthma. Severe asthma also amplified the deleterious associations that apolipoprotein E ε4 carrier status, cardiovascular risk, and phosphorylated tau181/amyloid beta42 have with rate of cognitive decline. Discussion Our data suggest that severe asthma is associated with synaptic degeneration and may compound risk for dementia posed by cardiovascular disease and genetic predisposition. Highlights Those with severe asthma showed evidence of higher dementia risk than controls evidenced by: higher levels of the synaptic degeneration biomarker neurogranin regardless of cognitive status, cardiovascular or genetic risk, and controlling for demographics. steeper increase in levels of synaptic degeneration biomarkers neurogranin and α‐synuclein with increasing cardiovascular risk. accelerated cognitive decline with higher cardiovascular risk, genetic predisposition, or pathological tau.https://doi.org/10.1002/trc2.12315Alzheimer's diseaseasthmacerebrospinal fluid biomarkerscognitioncomorbiditiesdementia |
| spellingShingle | Ajay Kumar Nair Carol A. Van Hulle Barbara B. Bendlin Henrik Zetterberg Kaj Blennow Norbert Wild Gwendlyn Kollmorgen Ivonne Suridjan William W. Busse Melissa A. Rosenkranz Asthma amplifies dementia risk: Evidence from CSF biomarkers and cognitive decline Alzheimer’s & Dementia: Translational Research & Clinical Interventions Alzheimer's disease asthma cerebrospinal fluid biomarkers cognition comorbidities dementia |
| title | Asthma amplifies dementia risk: Evidence from CSF biomarkers and cognitive decline |
| title_full | Asthma amplifies dementia risk: Evidence from CSF biomarkers and cognitive decline |
| title_fullStr | Asthma amplifies dementia risk: Evidence from CSF biomarkers and cognitive decline |
| title_full_unstemmed | Asthma amplifies dementia risk: Evidence from CSF biomarkers and cognitive decline |
| title_short | Asthma amplifies dementia risk: Evidence from CSF biomarkers and cognitive decline |
| title_sort | asthma amplifies dementia risk evidence from csf biomarkers and cognitive decline |
| topic | Alzheimer's disease asthma cerebrospinal fluid biomarkers cognition comorbidities dementia |
| url | https://doi.org/10.1002/trc2.12315 |
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