Post-translational modifications and bronchopulmonary dysplasia
Bronchopulmonary dysplasia is a prevalent respiratory disorder posing a significant threat to the quality of life in premature infants. Its pathogenesis is intricate, and therapeutic options are limited. Besides genetic coding, protein post-translational modification plays a pivotal role in regulati...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1426030/full |
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| author | Kun Yang Ting He Xue Sun Wenbin Dong |
| author_facet | Kun Yang Ting He Xue Sun Wenbin Dong |
| author_sort | Kun Yang |
| collection | DOAJ |
| description | Bronchopulmonary dysplasia is a prevalent respiratory disorder posing a significant threat to the quality of life in premature infants. Its pathogenesis is intricate, and therapeutic options are limited. Besides genetic coding, protein post-translational modification plays a pivotal role in regulating cellular function, contributing complexity and diversity to substrate proteins and influencing various cellular processes. Substantial evidence indicates that post-translational modifications of several substrate proteins are intricately related to the molecular mechanisms underlying bronchopulmonary dysplasia. These modifications facilitate the progression of bronchopulmonary dysplasia through a cascade of signal transduction events. This review outlines the relationships between substrate protein phosphorylation, acetylation, ubiquitination, SUMOylation, methylation, glycosylation, glycation, S-glutathionylation, S-nitrosylation and bronchopulmonary dysplasia. The aim is to provide novel insights into bronchopulmonary dysplasia's pathogenesis and potential therapeutic targets for clinical management. |
| format | Article |
| id | doaj-art-161195fba8cd42f98b3c55a5f335d571 |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-161195fba8cd42f98b3c55a5f335d5712025-01-03T05:10:25ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011210.3389/fped.2024.14260301426030Post-translational modifications and bronchopulmonary dysplasiaKun YangTing HeXue SunWenbin DongBronchopulmonary dysplasia is a prevalent respiratory disorder posing a significant threat to the quality of life in premature infants. Its pathogenesis is intricate, and therapeutic options are limited. Besides genetic coding, protein post-translational modification plays a pivotal role in regulating cellular function, contributing complexity and diversity to substrate proteins and influencing various cellular processes. Substantial evidence indicates that post-translational modifications of several substrate proteins are intricately related to the molecular mechanisms underlying bronchopulmonary dysplasia. These modifications facilitate the progression of bronchopulmonary dysplasia through a cascade of signal transduction events. This review outlines the relationships between substrate protein phosphorylation, acetylation, ubiquitination, SUMOylation, methylation, glycosylation, glycation, S-glutathionylation, S-nitrosylation and bronchopulmonary dysplasia. The aim is to provide novel insights into bronchopulmonary dysplasia's pathogenesis and potential therapeutic targets for clinical management.https://www.frontiersin.org/articles/10.3389/fped.2024.1426030/fullpost-translational modificationbronchopulmonary dysplasiahyperoxialung injurysubstrate protein |
| spellingShingle | Kun Yang Ting He Xue Sun Wenbin Dong Post-translational modifications and bronchopulmonary dysplasia Frontiers in Pediatrics post-translational modification bronchopulmonary dysplasia hyperoxia lung injury substrate protein |
| title | Post-translational modifications and bronchopulmonary dysplasia |
| title_full | Post-translational modifications and bronchopulmonary dysplasia |
| title_fullStr | Post-translational modifications and bronchopulmonary dysplasia |
| title_full_unstemmed | Post-translational modifications and bronchopulmonary dysplasia |
| title_short | Post-translational modifications and bronchopulmonary dysplasia |
| title_sort | post translational modifications and bronchopulmonary dysplasia |
| topic | post-translational modification bronchopulmonary dysplasia hyperoxia lung injury substrate protein |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1426030/full |
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