Increased occurrence of microstate class B as the independent risk factor for persistent psychiatric symptoms related to omicron infection
Objective: This study aimed to investigate the EEG microstate characteristics in patients with persistent Omicron-related Psychiatric Symptoms (ORPS) as well as their correlations with the severity of ORPS. Methods: This study included 31 patients with ORPS, and they were divided into remission grou...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-11-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923024002417 |
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| author | Qinlian Huang Linqi Liu Lihong Huang Wei Zheng Yuping Zhao Kebin Zeng Fei Xiao Jing Luo Feng Li |
| author_facet | Qinlian Huang Linqi Liu Lihong Huang Wei Zheng Yuping Zhao Kebin Zeng Fei Xiao Jing Luo Feng Li |
| author_sort | Qinlian Huang |
| collection | DOAJ |
| description | Objective: This study aimed to investigate the EEG microstate characteristics in patients with persistent Omicron-related Psychiatric Symptoms (ORPS) as well as their correlations with the severity of ORPS. Methods: This study included 31 patients with ORPS, and they were divided into remission group (n=19) and non-remission group (n=12) according to the decrease of Brief Psychiatric Rating Scale (BPRS) at discharge. Multivariate logistic models were applied to analyze the risk features associated with non-remission of ORPS at discharge, and the Spearman rank correlation was adopted to analyze the correlation between the occurrence of microstate class B and BPRS score at admission. Results: The analysis revealed that an increased occurrence of EEG microstate class B was significantly associated with a higher likelihood of non-remission of ORPS at discharge (p < 0.05). Furthermore, a moderate positive correlation was observed between the occurrence of microstate class B and BPRS scores at admission (r = 0.390, p = 0.030), indicating that patients with more frequent microstate class B tended to exhibit more severe psychiatric symptoms at onset. Conclusions: The findings suggest that an increased occurrence of EEG microstate class B is an independent risk factor for non-remission of ORPS at discharge. Additionally, the positive correlation between microstate class B and BPRS scores underscores the potential of microstate class B as a biomarker for the severity of psychiatric symptoms in ORPS patients. Significance: Identifying the increased occurrence of microstate class B at admission could serve as a novel marker for early assessment of ORPS severity and prognostic evaluation. |
| format | Article |
| id | doaj-art-160e5e12e44f4c438d8043b4c16c6f5b |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-160e5e12e44f4c438d8043b4c16c6f5b2024-11-10T04:07:38ZengElsevierBrain Research Bulletin1873-27472024-11-01218111107Increased occurrence of microstate class B as the independent risk factor for persistent psychiatric symptoms related to omicron infectionQinlian Huang0Linqi Liu1Lihong Huang2Wei Zheng3Yuping Zhao4Kebin Zeng5Fei Xiao6Jing Luo7Feng Li8Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR ChinaInstitutes of Neuroscience, Chongqing Medical University, Chongqing 400016, PR ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China; Corresponding authors.Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China; Corresponding authors.Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China; Corresponding authors.Objective: This study aimed to investigate the EEG microstate characteristics in patients with persistent Omicron-related Psychiatric Symptoms (ORPS) as well as their correlations with the severity of ORPS. Methods: This study included 31 patients with ORPS, and they were divided into remission group (n=19) and non-remission group (n=12) according to the decrease of Brief Psychiatric Rating Scale (BPRS) at discharge. Multivariate logistic models were applied to analyze the risk features associated with non-remission of ORPS at discharge, and the Spearman rank correlation was adopted to analyze the correlation between the occurrence of microstate class B and BPRS score at admission. Results: The analysis revealed that an increased occurrence of EEG microstate class B was significantly associated with a higher likelihood of non-remission of ORPS at discharge (p < 0.05). Furthermore, a moderate positive correlation was observed between the occurrence of microstate class B and BPRS scores at admission (r = 0.390, p = 0.030), indicating that patients with more frequent microstate class B tended to exhibit more severe psychiatric symptoms at onset. Conclusions: The findings suggest that an increased occurrence of EEG microstate class B is an independent risk factor for non-remission of ORPS at discharge. Additionally, the positive correlation between microstate class B and BPRS scores underscores the potential of microstate class B as a biomarker for the severity of psychiatric symptoms in ORPS patients. Significance: Identifying the increased occurrence of microstate class B at admission could serve as a novel marker for early assessment of ORPS severity and prognostic evaluation.http://www.sciencedirect.com/science/article/pii/S0361923024002417Psychiatric symptomsSARS-Cov-2OmicronEEGEEG microstate |
| spellingShingle | Qinlian Huang Linqi Liu Lihong Huang Wei Zheng Yuping Zhao Kebin Zeng Fei Xiao Jing Luo Feng Li Increased occurrence of microstate class B as the independent risk factor for persistent psychiatric symptoms related to omicron infection Brain Research Bulletin Psychiatric symptoms SARS-Cov-2 Omicron EEG EEG microstate |
| title | Increased occurrence of microstate class B as the independent risk factor for persistent psychiatric symptoms related to omicron infection |
| title_full | Increased occurrence of microstate class B as the independent risk factor for persistent psychiatric symptoms related to omicron infection |
| title_fullStr | Increased occurrence of microstate class B as the independent risk factor for persistent psychiatric symptoms related to omicron infection |
| title_full_unstemmed | Increased occurrence of microstate class B as the independent risk factor for persistent psychiatric symptoms related to omicron infection |
| title_short | Increased occurrence of microstate class B as the independent risk factor for persistent psychiatric symptoms related to omicron infection |
| title_sort | increased occurrence of microstate class b as the independent risk factor for persistent psychiatric symptoms related to omicron infection |
| topic | Psychiatric symptoms SARS-Cov-2 Omicron EEG EEG microstate |
| url | http://www.sciencedirect.com/science/article/pii/S0361923024002417 |
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