Increased occurrence of microstate class B as the independent risk factor for persistent psychiatric symptoms related to omicron infection
Objective: This study aimed to investigate the EEG microstate characteristics in patients with persistent Omicron-related Psychiatric Symptoms (ORPS) as well as their correlations with the severity of ORPS. Methods: This study included 31 patients with ORPS, and they were divided into remission grou...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-11-01
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| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923024002417 |
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| Summary: | Objective: This study aimed to investigate the EEG microstate characteristics in patients with persistent Omicron-related Psychiatric Symptoms (ORPS) as well as their correlations with the severity of ORPS. Methods: This study included 31 patients with ORPS, and they were divided into remission group (n=19) and non-remission group (n=12) according to the decrease of Brief Psychiatric Rating Scale (BPRS) at discharge. Multivariate logistic models were applied to analyze the risk features associated with non-remission of ORPS at discharge, and the Spearman rank correlation was adopted to analyze the correlation between the occurrence of microstate class B and BPRS score at admission. Results: The analysis revealed that an increased occurrence of EEG microstate class B was significantly associated with a higher likelihood of non-remission of ORPS at discharge (p < 0.05). Furthermore, a moderate positive correlation was observed between the occurrence of microstate class B and BPRS scores at admission (r = 0.390, p = 0.030), indicating that patients with more frequent microstate class B tended to exhibit more severe psychiatric symptoms at onset. Conclusions: The findings suggest that an increased occurrence of EEG microstate class B is an independent risk factor for non-remission of ORPS at discharge. Additionally, the positive correlation between microstate class B and BPRS scores underscores the potential of microstate class B as a biomarker for the severity of psychiatric symptoms in ORPS patients. Significance: Identifying the increased occurrence of microstate class B at admission could serve as a novel marker for early assessment of ORPS severity and prognostic evaluation. |
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| ISSN: | 1873-2747 |