Effects of induced subclinical hypocalcemia in early-lactation Holstein cows without milking during infusion on parathyroid hormone and serotonin concentrations
The transition to lactation demands a substantial amount of calcium (Ca) to support colostrum and milk production. Extensive research has been focused on elucidating the interplay between the traditional Ca-parathyroid hormone-vitamin D axis and mammary-derived factors, such as serotonin (5-HT) and...
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Elsevier
2024-11-01
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| Series: | JDS Communications |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266691022400098X |
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| author | W.S. Frizzarini J.P. Campolina M.K. Connelly H.P. Fricke L.L. Hernandez |
| author_facet | W.S. Frizzarini J.P. Campolina M.K. Connelly H.P. Fricke L.L. Hernandez |
| author_sort | W.S. Frizzarini |
| collection | DOAJ |
| description | The transition to lactation demands a substantial amount of calcium (Ca) to support colostrum and milk production. Extensive research has been focused on elucidating the interplay between the traditional Ca-parathyroid hormone-vitamin D axis and mammary-derived factors, such as serotonin (5-HT) and parathyroid-hormone-like hormone (PTHLH), in regulating Ca metabolism during the transition period. Here, we investigate the impact of induced subclinical hypocalcemia (SCH) on 5-HT and parathyroid hormone (PTH) concentrations in early-lactation dairy cows under conditions of 24-h milk stasis. Twelve multiparous Holstein cows in early lactation received either continuous intravenous infusion of saline solution or 5% ethylene glycol tetraacetic acid (EGTA) to maintain blood ionized calcium (iCa) below 1 mM (n = 6/treatment). Blood samples were collected hourly during infusion and 4, 8, 12, 24, and 48 h post-infusion. Urine samples were collected every 4 h during infusion and at 12, 24, and 48 h post-infusion, and milk samples were collected daily from 2 d pre-infusion to 4 d post-infusion. Infusion of EGTA resulted in decreased blood iCa during the infusion period, with iCa concentrations rebounding 24 h post-infusion. No significant treatment effects were observed on 5-HT and PTH blood concentrations. These findings underscore the importance of considering physiological distinctions in studies of Ca metabolism during the transition period. |
| format | Article |
| id | doaj-art-15f7be7f13b4449583b433ae5802eabe |
| institution | Kabale University |
| issn | 2666-9102 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JDS Communications |
| spelling | doaj-art-15f7be7f13b4449583b433ae5802eabe2024-11-22T07:39:22ZengElsevierJDS Communications2666-91022024-11-0156729734Effects of induced subclinical hypocalcemia in early-lactation Holstein cows without milking during infusion on parathyroid hormone and serotonin concentrationsW.S. Frizzarini0J.P. Campolina1M.K. Connelly2H.P. Fricke3L.L. Hernandez4Department of Animal and Dairy Sciences, University of Wisconsin–Madison, Madison, WI 53706Departmento de Zootecnia, Escola de Veterinaria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 30161-970, BrazilDepartment of Animal and Dairy Sciences, University of Wisconsin–Madison, Madison, WI 53706Department of Animal and Dairy Sciences, University of Wisconsin–Madison, Madison, WI 53706Department of Animal and Dairy Sciences, University of Wisconsin–Madison, Madison, WI 53706; Corresponding authorThe transition to lactation demands a substantial amount of calcium (Ca) to support colostrum and milk production. Extensive research has been focused on elucidating the interplay between the traditional Ca-parathyroid hormone-vitamin D axis and mammary-derived factors, such as serotonin (5-HT) and parathyroid-hormone-like hormone (PTHLH), in regulating Ca metabolism during the transition period. Here, we investigate the impact of induced subclinical hypocalcemia (SCH) on 5-HT and parathyroid hormone (PTH) concentrations in early-lactation dairy cows under conditions of 24-h milk stasis. Twelve multiparous Holstein cows in early lactation received either continuous intravenous infusion of saline solution or 5% ethylene glycol tetraacetic acid (EGTA) to maintain blood ionized calcium (iCa) below 1 mM (n = 6/treatment). Blood samples were collected hourly during infusion and 4, 8, 12, 24, and 48 h post-infusion. Urine samples were collected every 4 h during infusion and at 12, 24, and 48 h post-infusion, and milk samples were collected daily from 2 d pre-infusion to 4 d post-infusion. Infusion of EGTA resulted in decreased blood iCa during the infusion period, with iCa concentrations rebounding 24 h post-infusion. No significant treatment effects were observed on 5-HT and PTH blood concentrations. These findings underscore the importance of considering physiological distinctions in studies of Ca metabolism during the transition period.http://www.sciencedirect.com/science/article/pii/S266691022400098X |
| spellingShingle | W.S. Frizzarini J.P. Campolina M.K. Connelly H.P. Fricke L.L. Hernandez Effects of induced subclinical hypocalcemia in early-lactation Holstein cows without milking during infusion on parathyroid hormone and serotonin concentrations JDS Communications |
| title | Effects of induced subclinical hypocalcemia in early-lactation Holstein cows without milking during infusion on parathyroid hormone and serotonin concentrations |
| title_full | Effects of induced subclinical hypocalcemia in early-lactation Holstein cows without milking during infusion on parathyroid hormone and serotonin concentrations |
| title_fullStr | Effects of induced subclinical hypocalcemia in early-lactation Holstein cows without milking during infusion on parathyroid hormone and serotonin concentrations |
| title_full_unstemmed | Effects of induced subclinical hypocalcemia in early-lactation Holstein cows without milking during infusion on parathyroid hormone and serotonin concentrations |
| title_short | Effects of induced subclinical hypocalcemia in early-lactation Holstein cows without milking during infusion on parathyroid hormone and serotonin concentrations |
| title_sort | effects of induced subclinical hypocalcemia in early lactation holstein cows without milking during infusion on parathyroid hormone and serotonin concentrations |
| url | http://www.sciencedirect.com/science/article/pii/S266691022400098X |
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