TLR4/MyD88 expression patterns and novel genetic variants: association with aggressive clinicopathological features in colorectal cancer

TLR4/MyD88 expression patterns and novel genetic variants: association with aggressive clinicopathological features in colorectal cancer

BackgroundToll-like receptor 4 (TLR4) and myeloid differentiation factor 88 (MyD88) signaling play a critical role in colorectal cancer (CRC) development. Despite extensive research, the relationship between genetic variations and protein expression patterns during adenoma-carcinoma progression rema...

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Main Authors: Thai Tra Dang, Viet Nhat Pham, Ngoc Dung Tran, Thu Hang Ngo, Van Mao Can, Huy Hoang Nguyen, Thi Xuan Nguyen, Thanh Chung Dang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Oncology
Subjects:
TLR4/MyD88 pathway
colorectal carcinogenesis
genetic polymorphisms
molecular biomarkers
clinicopathological features
microsatellite instability
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1568729/full
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