A preliminary study of linear accelerator-based spatially fractionated radiotherapy
PurposeThis study aimed to provide quantitative information for implementing Lattice radiotherapy (LRT) using a medical linear accelerator equipped with the Millennium 120 multi-leaf collimator (MLC). The research systematically evaluated the impact of varying vertex diameters and separations on dos...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1495216/full |
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| author | Young Kyu Lee Yunji Seol Byeong Jin Kim Kyu Hye Choi Ji Hyun Hong Chan-beom Park Sun Hwa Kim Hyeong Wook Park Wonjoong Cheon Young Nam Kang Byung‑Ock Choi |
| author_facet | Young Kyu Lee Yunji Seol Byeong Jin Kim Kyu Hye Choi Ji Hyun Hong Chan-beom Park Sun Hwa Kim Hyeong Wook Park Wonjoong Cheon Young Nam Kang Byung‑Ock Choi |
| author_sort | Young Kyu Lee |
| collection | DOAJ |
| description | PurposeThis study aimed to provide quantitative information for implementing Lattice radiotherapy (LRT) using a medical linear accelerator equipped with the Millennium 120 multi-leaf collimator (MLC). The research systematically evaluated the impact of varying vertex diameters and separations on dose distribution, peak-to-valley dose ratio (PVDR), and normal tissue dose.MethodsA cylindrical Virtual Water™ phantom was used to create LRT treatments using the Eclipse version 16.0 treatment planning system (Varian, Palo Alto, USA). The plans were optimized employing a 3 × 3 × 3 lattice structure with vertex diameters ranging from 0.5 to 2.0 cm and separations from 1.0 to 5.0 cm. The prescribed dose was 20.0 Gy to 50% of the vertex volume in a single fraction. Peak-to-valley dose ratio (PVDR) was calculated along three orthogonal axes, and normal tissue dose and monitor units (MU) were analyzed. Additionally, the modulation complexity score (MCS) was calculated for each plan to quantitatively assess treatment plan complexity.ResultsThe PVDR analysis demonstrated heterogeneous dose distribution, with optimal values below 30% in all directions for 5.0 cm separation. PVDR in the superior-inferior direction was consistently lower than in other directions. Normal tissue dose analysis revealed increasing mean dose with larger diameters and separations, while the volume receiving high doses decreased. MU analysis showed significant contributions from collimator angles of 315.0° and 45.0°. MCS values ranged from 0.02 to 0.17 for 0.5 cm vertex diameter and 0.08 to 0.20 for larger diameters (1.0-2.0 cm) across different separations, respectively.ConclusionsThis study demonstrates the technical feasibility of implementing LRT using a medical linear accelerator with Millennium 120 MLC. The findings provide insights into optimizing LRT treatment plans, offering a comprehensive quantitative reference for achieving desired dose heterogeneity while maintaining normal tissue protection. |
| format | Article |
| id | doaj-art-15d8c5a8e16549c1a267b64334b98360 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-15d8c5a8e16549c1a267b64334b983602025-01-14T06:10:44ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14952161495216A preliminary study of linear accelerator-based spatially fractionated radiotherapyYoung Kyu Lee0Yunji Seol1Byeong Jin Kim2Kyu Hye Choi3Ji Hyun Hong4Chan-beom Park5Sun Hwa Kim6Hyeong Wook Park7Wonjoong Cheon8Young Nam Kang9Byung‑Ock Choi10Department of Radiation Oncology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Radiation Oncology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Radiation Oncology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Radiation Oncology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Radiation Oncology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Medical Physics, Kyonggi University, Suwon, Republic of KoreaDepartment of Radiation Oncology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Radiation Oncology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Radiation Oncology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaPurposeThis study aimed to provide quantitative information for implementing Lattice radiotherapy (LRT) using a medical linear accelerator equipped with the Millennium 120 multi-leaf collimator (MLC). The research systematically evaluated the impact of varying vertex diameters and separations on dose distribution, peak-to-valley dose ratio (PVDR), and normal tissue dose.MethodsA cylindrical Virtual Water™ phantom was used to create LRT treatments using the Eclipse version 16.0 treatment planning system (Varian, Palo Alto, USA). The plans were optimized employing a 3 × 3 × 3 lattice structure with vertex diameters ranging from 0.5 to 2.0 cm and separations from 1.0 to 5.0 cm. The prescribed dose was 20.0 Gy to 50% of the vertex volume in a single fraction. Peak-to-valley dose ratio (PVDR) was calculated along three orthogonal axes, and normal tissue dose and monitor units (MU) were analyzed. Additionally, the modulation complexity score (MCS) was calculated for each plan to quantitatively assess treatment plan complexity.ResultsThe PVDR analysis demonstrated heterogeneous dose distribution, with optimal values below 30% in all directions for 5.0 cm separation. PVDR in the superior-inferior direction was consistently lower than in other directions. Normal tissue dose analysis revealed increasing mean dose with larger diameters and separations, while the volume receiving high doses decreased. MU analysis showed significant contributions from collimator angles of 315.0° and 45.0°. MCS values ranged from 0.02 to 0.17 for 0.5 cm vertex diameter and 0.08 to 0.20 for larger diameters (1.0-2.0 cm) across different separations, respectively.ConclusionsThis study demonstrates the technical feasibility of implementing LRT using a medical linear accelerator with Millennium 120 MLC. The findings provide insights into optimizing LRT treatment plans, offering a comprehensive quantitative reference for achieving desired dose heterogeneity while maintaining normal tissue protection.https://www.frontiersin.org/articles/10.3389/fonc.2024.1495216/fullspatially fractionated radiation therapy (SFRT)lattice radiation therapy (LRT)multi-leaf collimator (MLC)peak-to-valley dose ratio (PVDR)monitor unit (MU) analysis |
| spellingShingle | Young Kyu Lee Yunji Seol Byeong Jin Kim Kyu Hye Choi Ji Hyun Hong Chan-beom Park Sun Hwa Kim Hyeong Wook Park Wonjoong Cheon Young Nam Kang Byung‑Ock Choi A preliminary study of linear accelerator-based spatially fractionated radiotherapy Frontiers in Oncology spatially fractionated radiation therapy (SFRT) lattice radiation therapy (LRT) multi-leaf collimator (MLC) peak-to-valley dose ratio (PVDR) monitor unit (MU) analysis |
| title | A preliminary study of linear accelerator-based spatially fractionated radiotherapy |
| title_full | A preliminary study of linear accelerator-based spatially fractionated radiotherapy |
| title_fullStr | A preliminary study of linear accelerator-based spatially fractionated radiotherapy |
| title_full_unstemmed | A preliminary study of linear accelerator-based spatially fractionated radiotherapy |
| title_short | A preliminary study of linear accelerator-based spatially fractionated radiotherapy |
| title_sort | preliminary study of linear accelerator based spatially fractionated radiotherapy |
| topic | spatially fractionated radiation therapy (SFRT) lattice radiation therapy (LRT) multi-leaf collimator (MLC) peak-to-valley dose ratio (PVDR) monitor unit (MU) analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1495216/full |
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