Electrochemical study of anti-platelets tirofiban HCl in dosage form using nanomaterials modified sensors: developed and green assessed by eco-scale and complex-GAPI approach
Abstract Tirofiban hydrochloride is used to inhibit platelet aggregation, which has a significant impact on the treatment of congestive heart failure the most common cause of death according to WHO. Therefore, its quantification in pharmaceutical dosage form is critical. In this work, an electrochem...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13065-024-01358-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544951908794368 |
|---|---|
| author | Mohamed. Rizk Maha Mahmoud Abou El-Alamin Ola Abd Elkhalek Hassan A. M. Hendawy |
| author_facet | Mohamed. Rizk Maha Mahmoud Abou El-Alamin Ola Abd Elkhalek Hassan A. M. Hendawy |
| author_sort | Mohamed. Rizk |
| collection | DOAJ |
| description | Abstract Tirofiban hydrochloride is used to inhibit platelet aggregation, which has a significant impact on the treatment of congestive heart failure the most common cause of death according to WHO. Therefore, its quantification in pharmaceutical dosage form is critical. In this work, an electrochemical method for the determination of tirofiban HCl in pharmaceutical dosage form was developed and validated. Carbon paste electrode modified with multi-walled carbon nanotubes (MWCNT) was utilized to examine the electrochemical response of tirofiban hydrochloride. Scanning electron microscopy and Energy-dispersive X-ray analysis was used to investigate the morphology of this electrode. A linear response was obtained within the range of (27.00–745.00 ng/mL) (5.4 × 10–5 M–1.5 × 10−3 M) with a correlation coefficient of 0.9995, and a detection limit of 15.50 ng/mL (3.1 × 10–5 M). The greenness profile of the method was assessed utilizing the eco-scale and the green analytical procedure Index. |
| format | Article |
| id | doaj-art-15d85cb9307a42b0940b0927b67cac13 |
| institution | Kabale University |
| issn | 2661-801X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Chemistry |
| spelling | doaj-art-15d85cb9307a42b0940b0927b67cac132025-01-12T12:06:42ZengBMCBMC Chemistry2661-801X2025-01-0119111210.1186/s13065-024-01358-1Electrochemical study of anti-platelets tirofiban HCl in dosage form using nanomaterials modified sensors: developed and green assessed by eco-scale and complex-GAPI approachMohamed. Rizk0Maha Mahmoud Abou El-Alamin1Ola Abd Elkhalek2Hassan A. M. Hendawy3Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Helwan UniversityDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Helwan UniversityDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Helwan UniversityNational Organization for Drug Control and Research (NODCAR)Abstract Tirofiban hydrochloride is used to inhibit platelet aggregation, which has a significant impact on the treatment of congestive heart failure the most common cause of death according to WHO. Therefore, its quantification in pharmaceutical dosage form is critical. In this work, an electrochemical method for the determination of tirofiban HCl in pharmaceutical dosage form was developed and validated. Carbon paste electrode modified with multi-walled carbon nanotubes (MWCNT) was utilized to examine the electrochemical response of tirofiban hydrochloride. Scanning electron microscopy and Energy-dispersive X-ray analysis was used to investigate the morphology of this electrode. A linear response was obtained within the range of (27.00–745.00 ng/mL) (5.4 × 10–5 M–1.5 × 10−3 M) with a correlation coefficient of 0.9995, and a detection limit of 15.50 ng/mL (3.1 × 10–5 M). The greenness profile of the method was assessed utilizing the eco-scale and the green analytical procedure Index.https://doi.org/10.1186/s13065-024-01358-1Carbon paste modificationsEco-friendlyElectrochemical analysisTirofibanAntiplatelet |
| spellingShingle | Mohamed. Rizk Maha Mahmoud Abou El-Alamin Ola Abd Elkhalek Hassan A. M. Hendawy Electrochemical study of anti-platelets tirofiban HCl in dosage form using nanomaterials modified sensors: developed and green assessed by eco-scale and complex-GAPI approach BMC Chemistry Carbon paste modifications Eco-friendly Electrochemical analysis Tirofiban Antiplatelet |
| title | Electrochemical study of anti-platelets tirofiban HCl in dosage form using nanomaterials modified sensors: developed and green assessed by eco-scale and complex-GAPI approach |
| title_full | Electrochemical study of anti-platelets tirofiban HCl in dosage form using nanomaterials modified sensors: developed and green assessed by eco-scale and complex-GAPI approach |
| title_fullStr | Electrochemical study of anti-platelets tirofiban HCl in dosage form using nanomaterials modified sensors: developed and green assessed by eco-scale and complex-GAPI approach |
| title_full_unstemmed | Electrochemical study of anti-platelets tirofiban HCl in dosage form using nanomaterials modified sensors: developed and green assessed by eco-scale and complex-GAPI approach |
| title_short | Electrochemical study of anti-platelets tirofiban HCl in dosage form using nanomaterials modified sensors: developed and green assessed by eco-scale and complex-GAPI approach |
| title_sort | electrochemical study of anti platelets tirofiban hcl in dosage form using nanomaterials modified sensors developed and green assessed by eco scale and complex gapi approach |
| topic | Carbon paste modifications Eco-friendly Electrochemical analysis Tirofiban Antiplatelet |
| url | https://doi.org/10.1186/s13065-024-01358-1 |
| work_keys_str_mv | AT mohamedrizk electrochemicalstudyofantiplateletstirofibanhclindosageformusingnanomaterialsmodifiedsensorsdevelopedandgreenassessedbyecoscaleandcomplexgapiapproach AT mahamahmoudabouelalamin electrochemicalstudyofantiplateletstirofibanhclindosageformusingnanomaterialsmodifiedsensorsdevelopedandgreenassessedbyecoscaleandcomplexgapiapproach AT olaabdelkhalek electrochemicalstudyofantiplateletstirofibanhclindosageformusingnanomaterialsmodifiedsensorsdevelopedandgreenassessedbyecoscaleandcomplexgapiapproach AT hassanamhendawy electrochemicalstudyofantiplateletstirofibanhclindosageformusingnanomaterialsmodifiedsensorsdevelopedandgreenassessedbyecoscaleandcomplexgapiapproach |