Helminths in alternative therapeutics of inflammatory bowel disease
Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is a nonspecific chronic inflammation of the gastrointestinal tract. Despite recent advances in therapeutics and newer management strategies, IBD largely remains untreatable. Helminth therapy is a promising alte...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of Intestinal Diseases
2025-01-01
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| Series: | Intestinal Research |
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| Online Access: | http://irjournal.org/upload/pdf/ir-2023-00059.pdf |
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| author | Himani Pandey Daryl W. T. Tang Sunny H. Wong Devi Lal |
| author_facet | Himani Pandey Daryl W. T. Tang Sunny H. Wong Devi Lal |
| author_sort | Himani Pandey |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is a nonspecific chronic inflammation of the gastrointestinal tract. Despite recent advances in therapeutics and newer management strategies, IBD largely remains untreatable. Helminth therapy is a promising alternative therapeutic for IBD that has gained some attention in the last two decades. Helminths have immunomodulatory effects and can alter the gut microbiota. The immunomodulatory effects include a strong Th2 immune response, T-regulatory cell response, and the production of regulatory cytokines. Although concrete evidence regarding the efficacy of helminth therapy in IBD is lacking, clinical studies and studies done in animal models have shown some promise. Most clinical studies have shown that helminth therapy is safe and easily tolerable. Extensive work has been done on the whipworm Trichuris, but other helminths, including Schistosoma, Trichinella, Heligmosomoides, and Ancylostoma, have also been explored for pre-clinical and animal studies. This review article summarizes the potential of helminth therapy as an alternative therapeutic or an adjuvant to the existing therapeutic procedures for IBD treatment. |
| format | Article |
| id | doaj-art-15c1144b11cf4f90b7f273a866929385 |
| institution | Kabale University |
| issn | 1598-9100 2288-1956 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Korean Association for the Study of Intestinal Diseases |
| record_format | Article |
| series | Intestinal Research |
| spelling | doaj-art-15c1144b11cf4f90b7f273a8669293852025-08-20T03:53:46ZengKorean Association for the Study of Intestinal DiseasesIntestinal Research1598-91002288-19562025-01-0123182210.5217/ir.2023.000591036Helminths in alternative therapeutics of inflammatory bowel diseaseHimani Pandey0Daryl W. T. Tang1Sunny H. Wong2Devi Lal3 Redcliffe Labs, Noida, India School of Biological Sciences, Nanyang Technological University, Singapore Centre for Microbiome Medicine, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore Department of Zoology, Ramjas College, University of Delhi, Delhi, IndiaInflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is a nonspecific chronic inflammation of the gastrointestinal tract. Despite recent advances in therapeutics and newer management strategies, IBD largely remains untreatable. Helminth therapy is a promising alternative therapeutic for IBD that has gained some attention in the last two decades. Helminths have immunomodulatory effects and can alter the gut microbiota. The immunomodulatory effects include a strong Th2 immune response, T-regulatory cell response, and the production of regulatory cytokines. Although concrete evidence regarding the efficacy of helminth therapy in IBD is lacking, clinical studies and studies done in animal models have shown some promise. Most clinical studies have shown that helminth therapy is safe and easily tolerable. Extensive work has been done on the whipworm Trichuris, but other helminths, including Schistosoma, Trichinella, Heligmosomoides, and Ancylostoma, have also been explored for pre-clinical and animal studies. This review article summarizes the potential of helminth therapy as an alternative therapeutic or an adjuvant to the existing therapeutic procedures for IBD treatment.http://irjournal.org/upload/pdf/ir-2023-00059.pdfinflammatory bowel diseaseulcerative colitiscrohn diseasehelminthsmicrobiota |
| spellingShingle | Himani Pandey Daryl W. T. Tang Sunny H. Wong Devi Lal Helminths in alternative therapeutics of inflammatory bowel disease Intestinal Research inflammatory bowel disease ulcerative colitis crohn disease helminths microbiota |
| title | Helminths in alternative therapeutics of inflammatory bowel disease |
| title_full | Helminths in alternative therapeutics of inflammatory bowel disease |
| title_fullStr | Helminths in alternative therapeutics of inflammatory bowel disease |
| title_full_unstemmed | Helminths in alternative therapeutics of inflammatory bowel disease |
| title_short | Helminths in alternative therapeutics of inflammatory bowel disease |
| title_sort | helminths in alternative therapeutics of inflammatory bowel disease |
| topic | inflammatory bowel disease ulcerative colitis crohn disease helminths microbiota |
| url | http://irjournal.org/upload/pdf/ir-2023-00059.pdf |
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