Circadian clock dysfunction in Parkinson’s disease: mechanisms, consequences, and therapeutic strategy

Abstract Parkinson’s Disease (PD) is a prevalent neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. This leads to hallmark motor features that include bradykinesia, resting tremor, rigidity, and postural instability, alongside with a ran...

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Bibliographic Details
Main Authors: Müge Yalçin, Valentina Grande, Tiago Fleming Outeiro, Angela Relόgio
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-01009-9
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