Choroidal evaluation of FTLD-Tau and biomarker-determined Alzheimer’s disease
Abstract Frontotemporal lobar degeneration with tauopathy (FTLD-Tau) can present clinically similar to Alzheimer’s disease but lacks a biomarker. Alzheimer’s disease has been associated with choroidal thinning compared to controls. We compared the choroid of 25 probable FTLD-Tau (pFTLD-Tau) patients...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-02020-z |
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| author | Benjamin J. Kim Tomas S. Aleman Katheryn A. Q. Cousins Ebenezer Daniel Eli Smith Emma Iacobucci Anton Kolomeyer Christopher K. Hwang Corey T. McMillan Vivianna M. Van Deerlin Jeffrey S. Phillips Yinxi Yu Gui-Shuang Ying David J. Irwin |
| author_facet | Benjamin J. Kim Tomas S. Aleman Katheryn A. Q. Cousins Ebenezer Daniel Eli Smith Emma Iacobucci Anton Kolomeyer Christopher K. Hwang Corey T. McMillan Vivianna M. Van Deerlin Jeffrey S. Phillips Yinxi Yu Gui-Shuang Ying David J. Irwin |
| author_sort | Benjamin J. Kim |
| collection | DOAJ |
| description | Abstract Frontotemporal lobar degeneration with tauopathy (FTLD-Tau) can present clinically similar to Alzheimer’s disease but lacks a biomarker. Alzheimer’s disease has been associated with choroidal thinning compared to controls. We compared the choroid of 25 probable FTLD-Tau (pFTLD-Tau) patients (42 eyes), 26 biomarker-determined probable Alzheimer’s disease neuropathologic change (pADNC) patients (49 eyes), and 53 normal controls (80 eyes). Cerebrospinal fluid biomarkers determined presence of ADNC. All pFTLD-Tau patients had a syndrome highly associated with FTLD-Tau. Optical coherence tomography was performed with masked manual choroidal thickness (CT) measurements. With Image J, binarized images determined the choroidal vascularity index (CVI). Linear regression with generalized estimating equations to account for inter-eye correlation was performed. For pFTLD-Tau, pADNC, and controls, the subfoveal CT was 308.9, 286.0, and 301.5 μm, and CVI was 0.72, 0.72, and 0.73, respectively (all p > 0.05 for each group comparison). Adjusting for demographics, the CT and CVI were not significantly different between groups, including 13 CT measurement locations (all p > 0.05). Among pADNC patients, an exploratory analysis found a correlation between CVI and disease duration (Pearson r = 0.32, p = 0.04). We found no significant difference of CT or CVI between pFTLD-Tau, pADNC, and controls. Additional studies are warranted to evaluate how CVI relates to ADNC. |
| format | Article |
| id | doaj-art-158ee7aa1a2c42aa8a1765b95ab8b13a |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-158ee7aa1a2c42aa8a1765b95ab8b13a2025-08-20T04:01:26ZengNature PortfolioScientific Reports2045-23222025-07-0115111110.1038/s41598-025-02020-zChoroidal evaluation of FTLD-Tau and biomarker-determined Alzheimer’s diseaseBenjamin J. Kim0Tomas S. Aleman1Katheryn A. Q. Cousins2Ebenezer Daniel3Eli Smith4Emma Iacobucci5Anton Kolomeyer6Christopher K. Hwang7Corey T. McMillan8Vivianna M. Van Deerlin9Jeffrey S. Phillips10Yinxi Yu11Gui-Shuang Ying12David J. Irwin13Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of PennsylvaniaScheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of PennsylvaniaFrontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of PennsylvaniaScheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of PennsylvaniaScheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of PennsylvaniaScheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of PennsylvaniaScheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of PennsylvaniaScheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of PennsylvaniaFrontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of PennsylvaniaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaFrontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of PennsylvaniaScheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of PennsylvaniaScheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of PennsylvaniaFrontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of PennsylvaniaAbstract Frontotemporal lobar degeneration with tauopathy (FTLD-Tau) can present clinically similar to Alzheimer’s disease but lacks a biomarker. Alzheimer’s disease has been associated with choroidal thinning compared to controls. We compared the choroid of 25 probable FTLD-Tau (pFTLD-Tau) patients (42 eyes), 26 biomarker-determined probable Alzheimer’s disease neuropathologic change (pADNC) patients (49 eyes), and 53 normal controls (80 eyes). Cerebrospinal fluid biomarkers determined presence of ADNC. All pFTLD-Tau patients had a syndrome highly associated with FTLD-Tau. Optical coherence tomography was performed with masked manual choroidal thickness (CT) measurements. With Image J, binarized images determined the choroidal vascularity index (CVI). Linear regression with generalized estimating equations to account for inter-eye correlation was performed. For pFTLD-Tau, pADNC, and controls, the subfoveal CT was 308.9, 286.0, and 301.5 μm, and CVI was 0.72, 0.72, and 0.73, respectively (all p > 0.05 for each group comparison). Adjusting for demographics, the CT and CVI were not significantly different between groups, including 13 CT measurement locations (all p > 0.05). Among pADNC patients, an exploratory analysis found a correlation between CVI and disease duration (Pearson r = 0.32, p = 0.04). We found no significant difference of CT or CVI between pFTLD-Tau, pADNC, and controls. Additional studies are warranted to evaluate how CVI relates to ADNC.https://doi.org/10.1038/s41598-025-02020-z |
| spellingShingle | Benjamin J. Kim Tomas S. Aleman Katheryn A. Q. Cousins Ebenezer Daniel Eli Smith Emma Iacobucci Anton Kolomeyer Christopher K. Hwang Corey T. McMillan Vivianna M. Van Deerlin Jeffrey S. Phillips Yinxi Yu Gui-Shuang Ying David J. Irwin Choroidal evaluation of FTLD-Tau and biomarker-determined Alzheimer’s disease Scientific Reports |
| title | Choroidal evaluation of FTLD-Tau and biomarker-determined Alzheimer’s disease |
| title_full | Choroidal evaluation of FTLD-Tau and biomarker-determined Alzheimer’s disease |
| title_fullStr | Choroidal evaluation of FTLD-Tau and biomarker-determined Alzheimer’s disease |
| title_full_unstemmed | Choroidal evaluation of FTLD-Tau and biomarker-determined Alzheimer’s disease |
| title_short | Choroidal evaluation of FTLD-Tau and biomarker-determined Alzheimer’s disease |
| title_sort | choroidal evaluation of ftld tau and biomarker determined alzheimer s disease |
| url | https://doi.org/10.1038/s41598-025-02020-z |
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