Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atrophic gastritis

Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atrophic gastritis

Abstract Purpose To identify key cellular changes and molecular events in atrophic mucosa, we aimed to elucidate the molecular mechanisms driving the occurrence of chronic atrophic gastritis (CAG). Methods We used single-cell RNA sequencing (scRNA-seq) to characterize changes in the epithelial state...

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Bibliographic Details
Main Authors: Lin Lin, Tingxuan Huang, Lizhi Li, Yang Lin, Feng Chen, Ziyi Zheng, Jie Zhou, Yizhe Wang, Weihao You, Yujie Duan, Yawen An, Shiwei He, Weimin Ye
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Translational Medicine
Subjects:
Single-cell RNA sequencing (scRNA-seq)
CAG
Detoxification
Immune dysfunction
Fibroblast
T-cell exhaustion
Online Access:https://doi.org/10.1186/s12967-025-06150-w
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