Effects of coenzyme q10 on lipid profile in streptozotocin induced diabetic rats
<b>Aim: </b>This research was carried out to evaluate the effects on lipid profile of Coenzyme Q10 in streptozotocin induced diabetic rats.<p> <b>Materials and Methods:</b> In the study, 38 adult male Wistar Abino rats were divided into five groups. Group I animals was...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1233 |
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| Summary: | <b>Aim: </b>This research was carried out to evaluate the effects on
lipid profile of Coenzyme Q10 in streptozotocin induced diabetic
rats.<p>
<b>Materials and Methods:</b> In the study, 38 adult male Wistar
Abino rats were divided into five groups. Group I animals
was no applied. Group II animals was intraperitoneally administered
0.3 ml corn oil daily and group III animals was
intraperitoneally administered 10 mg/kg CoQ10 in 0.3 ml
corn oil daily for four weeks. In group IV animals, diabetes
was induced by subcutaneous injections of 40 mg/kg streptozotocin
for two days as a single dose per day. In group V
animals, diabetes was induced by same protocol applied to
group IV and then these animals were intraperitoneally administered
10 mg/kg CoQ10 in 0.3 ml corn oil for four weeks.
It was determined plasma triglyceride, total cholesterol, LDL,
HDL, insulin and glucose levels in all groups. In liver sections,
the staining intensity of hepatocytes containing lipid droplets
were evaluated.<p>
<b>Results:</b> Experimentally diabetes increased triglyceride,
cholesterol and LDL levels, while these parameters decreased
with CoQ10 treatment to diabetic rats when compared
to diabetic group (P<0.05). Plasma HDL level was lower in
diabetic group and plasma HDL level with CoQ10 treatment
to diabetic rats increased to diabetic group (P<0.05). It was
observed an increase in the staining intensity of hepatocytes
containing lipid droplets in diabetes group. However, these
staining intensity decreased by administration of CoQ10 to
diabetic rats.<p>
<b>Conclusion:</b> According to these results, it could be say that
CoQ10 treatment recovered lipid abnormalities of diabetic
rats. |
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| ISSN: | 1309-6958 2146-1953 |