Prognosis of invasive encapsulated follicular variant and classical papillary thyroid carcinoma: a propensity score-matched study using the SEER database
Abstract The latest World Health Organization Classification of Tumors, Fifth Edition, recognizes the invasive encapsulated follicular variant of papillary thyroid carcinoma (IEFVPTC) as a distinct malignant entity rather than a subtype of papillary thyroid carcinoma (PTC). This reclassification hig...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-84425-w |
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| author | Shuai Jin Lang Xie Gongyou Zhang Lei Liu Kaide Xia Hongzhou Liu Haiwang Zhang Peng Li |
| author_facet | Shuai Jin Lang Xie Gongyou Zhang Lei Liu Kaide Xia Hongzhou Liu Haiwang Zhang Peng Li |
| author_sort | Shuai Jin |
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| description | Abstract The latest World Health Organization Classification of Tumors, Fifth Edition, recognizes the invasive encapsulated follicular variant of papillary thyroid carcinoma (IEFVPTC) as a distinct malignant entity rather than a subtype of papillary thyroid carcinoma (PTC). This reclassification highlights the need to explore potential prognostic differences between IEFVPTC and classic PTC. This study utilized the Surveillance, Epidemiology, and End Results (SEER) database to compare prognoses of patients diagnosed with IEFVPTC and classic PTC between 2004 and 2019. Propensity score matching (PSM) was employed to adjust for confounding variables and reduce selection bias. Kaplan-Meier survival curves and Cox regression models were used to evaluate overall survival (OS) between the two groups. A total of 1,530 IEFVPTC and 81,508 classic PTC patients were analyzed. Before PSM, significant differences were noted in race, T-stage, N-stage, M-stage, laterality, radiotherapy, surgical modality, tumor size, and income. Post-PSM, these differences were not statistically significant (p > 0.05). Kaplan-Meier curves and Cox regression models showed no significant differences in OS between IEFVPTC and classic PTC both before and after PSM. This PSM analysis revealed no significant differences in overall survival between patients with IEFVPTC and classic PTC, suggesting that the reclassification of IEFVPTC does not translate into distinct prognostic outcomes. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-151e08aee60d49c298e02233c0ed09d32025-01-05T12:18:17ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-024-84425-wPrognosis of invasive encapsulated follicular variant and classical papillary thyroid carcinoma: a propensity score-matched study using the SEER databaseShuai Jin0Lang Xie1Gongyou Zhang2Lei Liu3Kaide Xia4Hongzhou Liu5Haiwang Zhang6Peng Li7School of Biology and Engineering (School of Health Medicine Modern Industry), Guizhou Medical UniversityDepartment of Hospital Infection Management and Preventive Health Care, Zhejiang Provincial People’s Hospital Bijie HospitalSchool of Biology and Engineering (School of Health Medicine Modern Industry), Guizhou Medical UniversitySchool of Biology and Engineering (School of Health Medicine Modern Industry), Guizhou Medical UniversityGuiyang Maternal and Child Health Care Hospital, Guiyang Children’s HospitalDepartment of Endocrinology, First Hospital of Handan CityDepartment of Neurosurgery, Guizhou Provincial People’s HospitalTeaching and Research Management Section, Guiyang Public Health Clinical CenterAbstract The latest World Health Organization Classification of Tumors, Fifth Edition, recognizes the invasive encapsulated follicular variant of papillary thyroid carcinoma (IEFVPTC) as a distinct malignant entity rather than a subtype of papillary thyroid carcinoma (PTC). This reclassification highlights the need to explore potential prognostic differences between IEFVPTC and classic PTC. This study utilized the Surveillance, Epidemiology, and End Results (SEER) database to compare prognoses of patients diagnosed with IEFVPTC and classic PTC between 2004 and 2019. Propensity score matching (PSM) was employed to adjust for confounding variables and reduce selection bias. Kaplan-Meier survival curves and Cox regression models were used to evaluate overall survival (OS) between the two groups. A total of 1,530 IEFVPTC and 81,508 classic PTC patients were analyzed. Before PSM, significant differences were noted in race, T-stage, N-stage, M-stage, laterality, radiotherapy, surgical modality, tumor size, and income. Post-PSM, these differences were not statistically significant (p > 0.05). Kaplan-Meier curves and Cox regression models showed no significant differences in OS between IEFVPTC and classic PTC both before and after PSM. This PSM analysis revealed no significant differences in overall survival between patients with IEFVPTC and classic PTC, suggesting that the reclassification of IEFVPTC does not translate into distinct prognostic outcomes.https://doi.org/10.1038/s41598-024-84425-wInvasive encapsulated follicular variant of papillary thyroid carcinomaClassical papillary thyroid carcinomaSEER databasePropensity score matchingOverall survival |
| spellingShingle | Shuai Jin Lang Xie Gongyou Zhang Lei Liu Kaide Xia Hongzhou Liu Haiwang Zhang Peng Li Prognosis of invasive encapsulated follicular variant and classical papillary thyroid carcinoma: a propensity score-matched study using the SEER database Scientific Reports Invasive encapsulated follicular variant of papillary thyroid carcinoma Classical papillary thyroid carcinoma SEER database Propensity score matching Overall survival |
| title | Prognosis of invasive encapsulated follicular variant and classical papillary thyroid carcinoma: a propensity score-matched study using the SEER database |
| title_full | Prognosis of invasive encapsulated follicular variant and classical papillary thyroid carcinoma: a propensity score-matched study using the SEER database |
| title_fullStr | Prognosis of invasive encapsulated follicular variant and classical papillary thyroid carcinoma: a propensity score-matched study using the SEER database |
| title_full_unstemmed | Prognosis of invasive encapsulated follicular variant and classical papillary thyroid carcinoma: a propensity score-matched study using the SEER database |
| title_short | Prognosis of invasive encapsulated follicular variant and classical papillary thyroid carcinoma: a propensity score-matched study using the SEER database |
| title_sort | prognosis of invasive encapsulated follicular variant and classical papillary thyroid carcinoma a propensity score matched study using the seer database |
| topic | Invasive encapsulated follicular variant of papillary thyroid carcinoma Classical papillary thyroid carcinoma SEER database Propensity score matching Overall survival |
| url | https://doi.org/10.1038/s41598-024-84425-w |
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