Molecular and cellular determinants of L-Dopa-induced dyskinesia in Parkinson’s Disease

Molecular and cellular determinants of L-Dopa-induced dyskinesia in Parkinson’s Disease

Abstract Treatment with L-3,4-dihydroxyphenylalanine (L-Dopa) compensates for decreased striatal dopamine (DA) levels and reduces Parkinson’s disease (PD) symptoms. However, during disease progression, L-Dopa-induced dyskinesia (LID) develops virtually in all PD patients, making the control of PD sy...

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Main Authors: Federica Servillo, Maria De Carluccio, Giulia Di Lazzaro, Federica Campanelli, Gioia Marino, Giuseppina Natale, Ada Ledonne, Mariangela Massaro Cenere, Emanuela Paldino, Daniela Di Giuda, Anna Picca, Francesco Bove, Riccardo Di Iorio, Benedetta Angeloni, Angelo Tiziano Cimmino, Giovanni Bellomo, Barbara Picconi, Anna Rita Bentivoglio, Nicola Biagio Mercuri, Lucilla Parnetti, Veronica Ghiglieri, Maria Teresa Viscomi, Paolo Calabresi
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-024-00836-6
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