Compound heterozygous missense and intronic variants in B9D1 contribute to a recurrent Meckel syndrome pedigree

BackgroundMeckel syndrome (MKS) is an embryonically lethal ciliopathy with severe clinical manifestations, including defects of the central nervous system, bilateral renal cystic dysplasia, and postaxial polydactyly. B9 domain-containing 1 (B9D1, NP_056496.1) is a member of a small family of protein...

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Main Authors: Huining Jing, Bocheng Xu, Hao Wang, Shanling Liu, He Wang, Jingqun Mai, Wencong Yao, Zhu Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Genetics
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Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1663455/full
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