IL-12 mRNA-LNP promotes dermal resident memory CD4+ T cell development

IL-12 mRNA-LNP promotes dermal resident memory CD4+ T cell development

Abstract Dermal resident memory CD4+ T cells (dTrm) provide protection against vector-borne infections. However, the factors that promote their development remain unclear. We tested if an mRNA vaccine, encoding a protective leishmanial antigen, induced dTrm cells. The mRNA vaccine induced robust sys...

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Bibliographic Details
Main Authors: Anabel Zabala-Peñafiel, Claudia Gonzalez-Lombana, Mohamad-Gabriel Alameh, Lais A. Sacramento, Zhirong Mou, Anthony T. Phan, Emily A. Aunins, Ying K. Tam, Jude E. Uzonna, Drew Weissman, Christopher A. Hunter, Phillip Scott
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01213-x
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