Bio- synthesis zinc oxide nanoparticle: Azadirachta indica and Phyllanthus acidus mediated green approach for enhanced biological efficacy
The current research involved the synthesis of ZnO nanoparticles from the leaf and fruit extracts of Azaratchida indica and Phyllanthus acidus. ZnO nanoparticles exhibit diversified applications in medicine, agriculture and food industry. The synthesized nanoparticles were characterized using techni...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Chemical Physics Impact |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266702242500009X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841527149462290432 |
|---|---|
| author | G. Joesna Abdullah Alodhayb P. Sasikumar T. Lalitha Sree R. Zema Ferin D. Sankar A. Prabakaran M. Prasath Muthumareeswaran Muthuramamoorthy M. Gulam Mohamed M. Vimalan |
| author_facet | G. Joesna Abdullah Alodhayb P. Sasikumar T. Lalitha Sree R. Zema Ferin D. Sankar A. Prabakaran M. Prasath Muthumareeswaran Muthuramamoorthy M. Gulam Mohamed M. Vimalan |
| author_sort | G. Joesna |
| collection | DOAJ |
| description | The current research involved the synthesis of ZnO nanoparticles from the leaf and fruit extracts of Azaratchida indica and Phyllanthus acidus. ZnO nanoparticles exhibit diversified applications in medicine, agriculture and food industry. The synthesized nanoparticles were characterized using techniques such as Powder X-ray Diffraction (PXRD) and High-Resolution Transmission Electron Microscopy (HRTEM) studies which showed the shape and size of nanoparticles to be spherical with 16 mm and 20 mm. Invitro biological effects of ZnO NPs were studied including antidiabetic, antiinflammatory, anticancer, antibacterial, antifungal and DNA protection nicking assay. The synthesized ZnO NPs demonstrated cytotoxic effects on the cell lines at higher concentration. However, there was a significant increase in the inhibition of alpha amylase and alpha- glucosidase activity. Similar results were obtained in the study of antiinflammatory activity of ZnO NPs. The nanoparticles of ZnO showed prominent antibacterial and antifungal activity against E. coli, S aureus, K pneumoniae, S.typhi, Candida albicans and Aspergillus species respectively. DNA nicking protection assay studies have also shown pronounced anticancer effects. The Fourier-transform infrared (FTIR) spectrum indicates the presence of Zn-O stretching vibrations, confirming the formation of zinc oxide bonds. These findings confirms that ZnO nanoparticles from these extracts have properties that can be used safely and efficiently. |
| format | Article |
| id | doaj-art-14ca02298aac40dfa2501ae5b924ebbb |
| institution | Kabale University |
| issn | 2667-0224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Chemical Physics Impact |
| spelling | doaj-art-14ca02298aac40dfa2501ae5b924ebbb2025-01-16T04:29:22ZengElsevierChemical Physics Impact2667-02242025-06-0110100821Bio- synthesis zinc oxide nanoparticle: Azadirachta indica and Phyllanthus acidus mediated green approach for enhanced biological efficacyG. Joesna0Abdullah Alodhayb1P. Sasikumar2T. Lalitha Sree3R. Zema Ferin4D. Sankar5A. Prabakaran6M. Prasath7Muthumareeswaran Muthuramamoorthy8M. Gulam Mohamed9M. Vimalan10Department of Physics, The New College (Autonomous), Chennai-600 014, IndiaKing Abdullah Institute of Nanotechnology, King Saud University, P.O. 2455, Riyadh, 11451, Saudi ArabiaDepartment of Physics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai-602 105, IndiaDepartment of Biochemistry, Valliammal College for Women, Chennai-600 102, IndiaDepartment of Physics, The New College (Autonomous), Chennai-600 014, IndiaDepartment of Physics, The New College (Autonomous), Chennai-600 014, IndiaDepartment of Physics, Vel Tech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Avadi, Chennai, 600062, IndiaDepartment of Physics, Periyar University Centre for Post Graduate and Research Studies, Dharmapuri, Tamil Nadu, IndiaKing Abdullah Institute of Nanotechnology, King Saud University, P.O. 2455, Riyadh, 11451, Saudi ArabiaDepartment of Physics, The New College (Autonomous), Chennai-600 014, India; Corresponding author at: Department of Physics, The New College (Autonomous), Chennai - 600 014, India.Department of Physics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai-602 105, India; Corresponding author at: Department of Physics, Saveetha School of Engineering, Saveetha Institute of medical and Technical Sciences (SIMATS), Chennai-602 105, India.The current research involved the synthesis of ZnO nanoparticles from the leaf and fruit extracts of Azaratchida indica and Phyllanthus acidus. ZnO nanoparticles exhibit diversified applications in medicine, agriculture and food industry. The synthesized nanoparticles were characterized using techniques such as Powder X-ray Diffraction (PXRD) and High-Resolution Transmission Electron Microscopy (HRTEM) studies which showed the shape and size of nanoparticles to be spherical with 16 mm and 20 mm. Invitro biological effects of ZnO NPs were studied including antidiabetic, antiinflammatory, anticancer, antibacterial, antifungal and DNA protection nicking assay. The synthesized ZnO NPs demonstrated cytotoxic effects on the cell lines at higher concentration. However, there was a significant increase in the inhibition of alpha amylase and alpha- glucosidase activity. Similar results were obtained in the study of antiinflammatory activity of ZnO NPs. The nanoparticles of ZnO showed prominent antibacterial and antifungal activity against E. coli, S aureus, K pneumoniae, S.typhi, Candida albicans and Aspergillus species respectively. DNA nicking protection assay studies have also shown pronounced anticancer effects. The Fourier-transform infrared (FTIR) spectrum indicates the presence of Zn-O stretching vibrations, confirming the formation of zinc oxide bonds. These findings confirms that ZnO nanoparticles from these extracts have properties that can be used safely and efficiently.http://www.sciencedirect.com/science/article/pii/S266702242500009XNanoparticlesGreen synthesisAnti-diabeticAnti-inflammatoryAnti-microbial |
| spellingShingle | G. Joesna Abdullah Alodhayb P. Sasikumar T. Lalitha Sree R. Zema Ferin D. Sankar A. Prabakaran M. Prasath Muthumareeswaran Muthuramamoorthy M. Gulam Mohamed M. Vimalan Bio- synthesis zinc oxide nanoparticle: Azadirachta indica and Phyllanthus acidus mediated green approach for enhanced biological efficacy Chemical Physics Impact Nanoparticles Green synthesis Anti-diabetic Anti-inflammatory Anti-microbial |
| title | Bio- synthesis zinc oxide nanoparticle: Azadirachta indica and Phyllanthus acidus mediated green approach for enhanced biological efficacy |
| title_full | Bio- synthesis zinc oxide nanoparticle: Azadirachta indica and Phyllanthus acidus mediated green approach for enhanced biological efficacy |
| title_fullStr | Bio- synthesis zinc oxide nanoparticle: Azadirachta indica and Phyllanthus acidus mediated green approach for enhanced biological efficacy |
| title_full_unstemmed | Bio- synthesis zinc oxide nanoparticle: Azadirachta indica and Phyllanthus acidus mediated green approach for enhanced biological efficacy |
| title_short | Bio- synthesis zinc oxide nanoparticle: Azadirachta indica and Phyllanthus acidus mediated green approach for enhanced biological efficacy |
| title_sort | bio synthesis zinc oxide nanoparticle azadirachta indica and phyllanthus acidus mediated green approach for enhanced biological efficacy |
| topic | Nanoparticles Green synthesis Anti-diabetic Anti-inflammatory Anti-microbial |
| url | http://www.sciencedirect.com/science/article/pii/S266702242500009X |
| work_keys_str_mv | AT gjoesna biosynthesiszincoxidenanoparticleazadirachtaindicaandphyllanthusacidusmediatedgreenapproachforenhancedbiologicalefficacy AT abdullahalodhayb biosynthesiszincoxidenanoparticleazadirachtaindicaandphyllanthusacidusmediatedgreenapproachforenhancedbiologicalefficacy AT psasikumar biosynthesiszincoxidenanoparticleazadirachtaindicaandphyllanthusacidusmediatedgreenapproachforenhancedbiologicalefficacy AT tlalithasree biosynthesiszincoxidenanoparticleazadirachtaindicaandphyllanthusacidusmediatedgreenapproachforenhancedbiologicalefficacy AT rzemaferin biosynthesiszincoxidenanoparticleazadirachtaindicaandphyllanthusacidusmediatedgreenapproachforenhancedbiologicalefficacy AT dsankar biosynthesiszincoxidenanoparticleazadirachtaindicaandphyllanthusacidusmediatedgreenapproachforenhancedbiologicalefficacy AT aprabakaran biosynthesiszincoxidenanoparticleazadirachtaindicaandphyllanthusacidusmediatedgreenapproachforenhancedbiologicalefficacy AT mprasath biosynthesiszincoxidenanoparticleazadirachtaindicaandphyllanthusacidusmediatedgreenapproachforenhancedbiologicalefficacy AT muthumareeswaranmuthuramamoorthy biosynthesiszincoxidenanoparticleazadirachtaindicaandphyllanthusacidusmediatedgreenapproachforenhancedbiologicalefficacy AT mgulammohamed biosynthesiszincoxidenanoparticleazadirachtaindicaandphyllanthusacidusmediatedgreenapproachforenhancedbiologicalefficacy AT mvimalan biosynthesiszincoxidenanoparticleazadirachtaindicaandphyllanthusacidusmediatedgreenapproachforenhancedbiologicalefficacy |