Smaller-incision new-generation implantable miniature telescope in late-stage age-related macular degeneration: 6 month outcomes
Purpose: To evaluate the intermediate-term visual and safety outcomes of the small-incision second-generation implantable miniature telescope (SING IMT) in patients with late-stage age-related macular degeneration (AMD) at 6 months post-surgery. Design: Retrospective cohort study. Methods: Medical r...
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024171472 |
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| author | Mario Damiano Toro Alfonso Savastano Faustino Vidal Aroca Paola Sasso Giuseppe Francione Gaetano Fioretto Marina Montemagni Claudio Xompero Nicola Claudio D'Onofrio Ciro Costagliola Stanislao Rizzo |
| author_facet | Mario Damiano Toro Alfonso Savastano Faustino Vidal Aroca Paola Sasso Giuseppe Francione Gaetano Fioretto Marina Montemagni Claudio Xompero Nicola Claudio D'Onofrio Ciro Costagliola Stanislao Rizzo |
| author_sort | Mario Damiano Toro |
| collection | DOAJ |
| description | Purpose: To evaluate the intermediate-term visual and safety outcomes of the small-incision second-generation implantable miniature telescope (SING IMT) in patients with late-stage age-related macular degeneration (AMD) at 6 months post-surgery. Design: Retrospective cohort study. Methods: Medical records of patients implanted with the SING IMT at two sites in Italy were reviewed. Outcomes evaluated up to 6 months post-surgery included best-corrected distance (BCDVA) and distance-corrected near (DCNVA) visual acuity, intraocular pressure (IOP), anterior chamber depth (ACD), corneal endothelial cell density (ECD), and adverse events. Results: The study involved 35 patients (mean age: 77.4 years). At 6 months post-surgery, the mean ± standard deviation (SD) change in BCDVA from baseline was −0.29 ± 0.142, and at least 1-, 2-, and 3-line gains in BCDVA were achieved in 97.1 %, 68.6 % and 51.4 %, of operated eyes, respectively. The percentage of patients able to read at near distance increased from 28.6 % at baseline to 97.1 % at 6 months post-surgery with a mean improvement of −0.57 ± 0.206. No clinically meaningful change from baseline was observed in terms of IOP or ACD. The mean (SD) change from baseline in ECD at 6 months in operated eyes was −280.7 (315.9) cells/mm2 (−11.4 %). The most frequent adverse event was corneal edema, and all cases were resolved with topical medications. Conclusions: This intermediate-term assessment confirms that SING IMT implantation improved distance and near vision, with a low impact on the corneal endothelium and an acceptable and manageable rate of complications and adverse effects. |
| format | Article |
| id | doaj-art-14aa7dbaad3e44709356468843cba845 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-14aa7dbaad3e44709356468843cba8452025-01-17T04:50:12ZengElsevierHeliyon2405-84402025-01-01111e41116Smaller-incision new-generation implantable miniature telescope in late-stage age-related macular degeneration: 6 month outcomesMario Damiano Toro0Alfonso Savastano1Faustino Vidal Aroca2Paola Sasso3Giuseppe Francione4Gaetano Fioretto5Marina Montemagni6Claudio Xompero7Nicola Claudio D'Onofrio8Ciro Costagliola9Stanislao Rizzo10Eye Clinic, Department of Public Health, University of Naples Federico II, 80131, Naples, Italy; Corresponding author.Libera Università Mediterranea Degennaro (L.U.M.), Casamassima (BA), Italy; Ospedale Regionale Generale “F. Miulli”, Acquaviva delle Fonti (BA), ItalyDepartment of Medical Scientific Affairs, Samsara Vision, Milan, ItalyOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, ItalyEye Clinic, Department of Neurosciences, Reproductive and Dentistry Sciences, University of Naples Federico II, 80131, Naples, ItalyEye Clinic, Department of Neurosciences, Reproductive and Dentistry Sciences, University of Naples Federico II, 80131, Naples, ItalyEye Clinic, Department of Neurosciences, Reproductive and Dentistry Sciences, University of Naples Federico II, 80131, Naples, ItalyOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, ItalyEye Clinic, Department of Neurosciences, Reproductive and Dentistry Sciences, University of Naples Federico II, 80131, Naples, ItalyOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy; Consiglio Nazionale delle Ricerche, Istituto di Neuroscienze, Pisa, ItalyPurpose: To evaluate the intermediate-term visual and safety outcomes of the small-incision second-generation implantable miniature telescope (SING IMT) in patients with late-stage age-related macular degeneration (AMD) at 6 months post-surgery. Design: Retrospective cohort study. Methods: Medical records of patients implanted with the SING IMT at two sites in Italy were reviewed. Outcomes evaluated up to 6 months post-surgery included best-corrected distance (BCDVA) and distance-corrected near (DCNVA) visual acuity, intraocular pressure (IOP), anterior chamber depth (ACD), corneal endothelial cell density (ECD), and adverse events. Results: The study involved 35 patients (mean age: 77.4 years). At 6 months post-surgery, the mean ± standard deviation (SD) change in BCDVA from baseline was −0.29 ± 0.142, and at least 1-, 2-, and 3-line gains in BCDVA were achieved in 97.1 %, 68.6 % and 51.4 %, of operated eyes, respectively. The percentage of patients able to read at near distance increased from 28.6 % at baseline to 97.1 % at 6 months post-surgery with a mean improvement of −0.57 ± 0.206. No clinically meaningful change from baseline was observed in terms of IOP or ACD. The mean (SD) change from baseline in ECD at 6 months in operated eyes was −280.7 (315.9) cells/mm2 (−11.4 %). The most frequent adverse event was corneal edema, and all cases were resolved with topical medications. Conclusions: This intermediate-term assessment confirms that SING IMT implantation improved distance and near vision, with a low impact on the corneal endothelium and an acceptable and manageable rate of complications and adverse effects.http://www.sciencedirect.com/science/article/pii/S2405844024171472Age-related macular degenerationDisciform scarGeographic atrophyLow visionSmall-incision new-generation implantable miniature telescopeRehabilitation |
| spellingShingle | Mario Damiano Toro Alfonso Savastano Faustino Vidal Aroca Paola Sasso Giuseppe Francione Gaetano Fioretto Marina Montemagni Claudio Xompero Nicola Claudio D'Onofrio Ciro Costagliola Stanislao Rizzo Smaller-incision new-generation implantable miniature telescope in late-stage age-related macular degeneration: 6 month outcomes Heliyon Age-related macular degeneration Disciform scar Geographic atrophy Low vision Small-incision new-generation implantable miniature telescope Rehabilitation |
| title | Smaller-incision new-generation implantable miniature telescope in late-stage age-related macular degeneration: 6 month outcomes |
| title_full | Smaller-incision new-generation implantable miniature telescope in late-stage age-related macular degeneration: 6 month outcomes |
| title_fullStr | Smaller-incision new-generation implantable miniature telescope in late-stage age-related macular degeneration: 6 month outcomes |
| title_full_unstemmed | Smaller-incision new-generation implantable miniature telescope in late-stage age-related macular degeneration: 6 month outcomes |
| title_short | Smaller-incision new-generation implantable miniature telescope in late-stage age-related macular degeneration: 6 month outcomes |
| title_sort | smaller incision new generation implantable miniature telescope in late stage age related macular degeneration 6 month outcomes |
| topic | Age-related macular degeneration Disciform scar Geographic atrophy Low vision Small-incision new-generation implantable miniature telescope Rehabilitation |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024171472 |
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