Selenium and bone health: a protocol for a systematic review and meta-analysis
Introduction Bone health affects the ability of human body to stay active, and its degradation can cause considerable morbidity and mortality. The factors related to bone health play an important role in preventing osteoporosis and its adverse consequences. However, the risk factors for osteoporosis...
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BMJ Publishing Group
2020-10-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/10/e036612.full |
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| author | Jing Wu Ziying Wu Tuo Yang Yilun Wang Dongxing Xie Hongyi He Zidan Yang Ning Wang |
| author_facet | Jing Wu Ziying Wu Tuo Yang Yilun Wang Dongxing Xie Hongyi He Zidan Yang Ning Wang |
| author_sort | Jing Wu |
| collection | DOAJ |
| description | Introduction Bone health affects the ability of human body to stay active, and its degradation can cause considerable morbidity and mortality. The factors related to bone health play an important role in preventing osteoporosis and its adverse consequences. However, the risk factors for osteoporosis have not been fully elucidated. Deficiency in the trace element selenium may be one of the risk factors for the development of osteoporosis. Previous studies have investigated the effects of selenium on osteoporosis; however, the results are inconclusive. Therefore, the present study aimed to systematically examine the existing literature on the associations between dietary or serum selenium and bone mineral density (BMD), osteoporosis or osteoporotic fractures, and to quantify such associations through meta-analysis.Methods and analysis PubMed, Embase and Cochrane Library will be searched using a specified search strategy to identify relevant studies up to October 2019. Both interventional and observational studies in humans will be included. The outcomes will include BMD and the prevalence or incidence of osteoporosis and osteoporotic fractures. For dietary or serum selenium and BMD, osteoporosis or osteoporotic fractures pooled analyses, estimates will be expressed as the mean difference, and the pooled OR, relative risk, HR or beta coefficient, and corresponding 95% CIs. Heterogeneity of the studies and publication bias will be investigated accordingly. To assess the quality and the risk of bias of the included studies, the Newcastle-Ottawa Quality Scale or the Cochrane risk of bias assessment tool will be used where appropriate.Ethics and dissemination Since no private and confidential patient data will be included in the reporting, approval from an ethics committee is not required. The results will be published in a peer-reviewed journal. The study raises no ethical issues.PROSPERO registration number CRD42019147188. |
| format | Article |
| id | doaj-art-14a12354ee1b44b8af2a2d9d637e0636 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-14a12354ee1b44b8af2a2d9d637e06362024-11-16T13:00:09ZengBMJ Publishing GroupBMJ Open2044-60552020-10-01101010.1136/bmjopen-2019-036612Selenium and bone health: a protocol for a systematic review and meta-analysisJing Wu0Ziying Wu1Tuo Yang2Yilun Wang3Dongxing Xie4Hongyi He5Zidan Yang6Ning Wang7National Center for Chronic and Non-Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, ChinaHealth Management Center, Xiangya Hospital, Central South University, Changsha, China1 Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopaedics, Xiangya Hospital Central South University, Changsha, Hunan, ChinaDepartment of Orthopaedics, Xiangya Hospital Central South University, Changsha, Hunan, ChinaKey Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Zoology, Chinese Academy of Sciences, Beijing, People`s Republic of ChinaIntroduction Bone health affects the ability of human body to stay active, and its degradation can cause considerable morbidity and mortality. The factors related to bone health play an important role in preventing osteoporosis and its adverse consequences. However, the risk factors for osteoporosis have not been fully elucidated. Deficiency in the trace element selenium may be one of the risk factors for the development of osteoporosis. Previous studies have investigated the effects of selenium on osteoporosis; however, the results are inconclusive. Therefore, the present study aimed to systematically examine the existing literature on the associations between dietary or serum selenium and bone mineral density (BMD), osteoporosis or osteoporotic fractures, and to quantify such associations through meta-analysis.Methods and analysis PubMed, Embase and Cochrane Library will be searched using a specified search strategy to identify relevant studies up to October 2019. Both interventional and observational studies in humans will be included. The outcomes will include BMD and the prevalence or incidence of osteoporosis and osteoporotic fractures. For dietary or serum selenium and BMD, osteoporosis or osteoporotic fractures pooled analyses, estimates will be expressed as the mean difference, and the pooled OR, relative risk, HR or beta coefficient, and corresponding 95% CIs. Heterogeneity of the studies and publication bias will be investigated accordingly. To assess the quality and the risk of bias of the included studies, the Newcastle-Ottawa Quality Scale or the Cochrane risk of bias assessment tool will be used where appropriate.Ethics and dissemination Since no private and confidential patient data will be included in the reporting, approval from an ethics committee is not required. The results will be published in a peer-reviewed journal. The study raises no ethical issues.PROSPERO registration number CRD42019147188.https://bmjopen.bmj.com/content/10/10/e036612.full |
| spellingShingle | Jing Wu Ziying Wu Tuo Yang Yilun Wang Dongxing Xie Hongyi He Zidan Yang Ning Wang Selenium and bone health: a protocol for a systematic review and meta-analysis BMJ Open |
| title | Selenium and bone health: a protocol for a systematic review and meta-analysis |
| title_full | Selenium and bone health: a protocol for a systematic review and meta-analysis |
| title_fullStr | Selenium and bone health: a protocol for a systematic review and meta-analysis |
| title_full_unstemmed | Selenium and bone health: a protocol for a systematic review and meta-analysis |
| title_short | Selenium and bone health: a protocol for a systematic review and meta-analysis |
| title_sort | selenium and bone health a protocol for a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/10/10/e036612.full |
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