Association between Methylmalonic Acid and Abdominal Aortic Calcification in Adults: A Cross-Sectional Study
Objective: Methylmalonic acid (MMA) buildup has recently been suggested to contribute to the onset of both age-related conditions and cardiovascular disorders. This research was aimed at examining the link between MMA and abdominal aortic calcification (AAC). Methods: Data from the 2013–2014 Natio...
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| Format: | Article |
| Language: | English |
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Compuscript Ltd
2024-03-01
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| Series: | Cardiovascular Innovations and Applications |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2024.0021 |
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| author | Jun Chen Yingwen Lin Zhonghua Teng Zhibin Lin Junrui Li Qingchun Zeng |
| author_facet | Jun Chen Yingwen Lin Zhonghua Teng Zhibin Lin Junrui Li Qingchun Zeng |
| author_sort | Jun Chen |
| collection | DOAJ |
| description | Objective: Methylmalonic acid (MMA) buildup has recently been suggested to contribute to the onset of both age-related conditions and cardiovascular disorders. This research was aimed at examining the link between MMA and abdominal aortic calcification (AAC). Methods: Data from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) were analyzed. Serum MMA levels were determined through LC-MS/MS, and MMA levels 250 nmol/L or above were considered high. Dual-energy X-ray absorptiometry was used to assess the presence of AAC. Logistic regression analysis was performed after propensity score matching (PSM) to study the relationship between MMA and AAC. Results: A total of 2483 participants were involved in this study. To eliminate large differences between the AAC and non-AAC groups, 1:1 PSM was performed. Logistic regression analysis indicated that participants with high MMA levels had a significantly greater likelihood of experiencing AAC than those with low MMA levels (OR: 1.38, 95% CI: 1.01–1.90, P = 0.046). No statistically interaction effects between AAC and BMI or the estimated glomerular filtration rate (eGFR) were observed in subgroup analyses. Conclusion: Our study indicated a significant association between high serum MMA levels and AAC incidence. |
| format | Article |
| id | doaj-art-14551d1b0a044bdbbe1ee9ba9bc42dd7 |
| institution | Kabale University |
| issn | 2009-8618 2009-8782 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | Cardiovascular Innovations and Applications |
| spelling | doaj-art-14551d1b0a044bdbbe1ee9ba9bc42dd72024-11-12T17:00:19ZengCompuscript LtdCardiovascular Innovations and Applications2009-86182009-87822024-03-019195510.15212/CVIA.2024.0021Association between Methylmalonic Acid and Abdominal Aortic Calcification in Adults: A Cross-Sectional StudyJun ChenYingwen LinZhonghua TengZhibin LinJunrui LiQingchun ZengObjective: Methylmalonic acid (MMA) buildup has recently been suggested to contribute to the onset of both age-related conditions and cardiovascular disorders. This research was aimed at examining the link between MMA and abdominal aortic calcification (AAC). Methods: Data from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) were analyzed. Serum MMA levels were determined through LC-MS/MS, and MMA levels 250 nmol/L or above were considered high. Dual-energy X-ray absorptiometry was used to assess the presence of AAC. Logistic regression analysis was performed after propensity score matching (PSM) to study the relationship between MMA and AAC. Results: A total of 2483 participants were involved in this study. To eliminate large differences between the AAC and non-AAC groups, 1:1 PSM was performed. Logistic regression analysis indicated that participants with high MMA levels had a significantly greater likelihood of experiencing AAC than those with low MMA levels (OR: 1.38, 95% CI: 1.01–1.90, P = 0.046). No statistically interaction effects between AAC and BMI or the estimated glomerular filtration rate (eGFR) were observed in subgroup analyses. Conclusion: Our study indicated a significant association between high serum MMA levels and AAC incidence.https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2024.0021 |
| spellingShingle | Jun Chen Yingwen Lin Zhonghua Teng Zhibin Lin Junrui Li Qingchun Zeng Association between Methylmalonic Acid and Abdominal Aortic Calcification in Adults: A Cross-Sectional Study Cardiovascular Innovations and Applications |
| title | Association between Methylmalonic Acid and Abdominal Aortic Calcification in Adults: A Cross-Sectional Study |
| title_full | Association between Methylmalonic Acid and Abdominal Aortic Calcification in Adults: A Cross-Sectional Study |
| title_fullStr | Association between Methylmalonic Acid and Abdominal Aortic Calcification in Adults: A Cross-Sectional Study |
| title_full_unstemmed | Association between Methylmalonic Acid and Abdominal Aortic Calcification in Adults: A Cross-Sectional Study |
| title_short | Association between Methylmalonic Acid and Abdominal Aortic Calcification in Adults: A Cross-Sectional Study |
| title_sort | association between methylmalonic acid and abdominal aortic calcification in adults a cross sectional study |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2024.0021 |
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