Augmented immunogenicity of the HPV16 DNA vaccine via dual adjuvant approach: integration of CpG ODN into plasmid backbone and co-administration with IL-28B gene adjuvant

Abstract Therapeutic human papillomavirus (HPV) DNA vaccine is an attractive option to control existed HPV infection and related lesions. The two early viral oncoproteins, E6 and E7, are continuously expressed in most HPV-related pre- and cancerous cells, and are ideal targets for therapeutic vaccin...

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Bibliographic Details
Main Authors: Yan Zhou, Ting Zhang, Zhirong Wang, Xuemei Xu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Virology Journal
Subjects:
Online Access:https://doi.org/10.1186/s12985-024-02604-7
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