High-performance modified LDH for green one-pot synthesis of pyrido[2,3-d]pyrimidines
This study introduces a new nano catalyst tailored for the eco-friendly synthesis of pyrido[2,3-d]pyrimidine via a three-component one-pot reaction involving benzaldehydes, malononitrile, and uracil. To achieve this objective, we anchored copper acetate onto the surface of layered double hydroxides...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024171800 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841526173900734464 |
|---|---|
| author | Sarieh Momeni Ramin Ghorbani-Vaghei |
| author_facet | Sarieh Momeni Ramin Ghorbani-Vaghei |
| author_sort | Sarieh Momeni |
| collection | DOAJ |
| description | This study introduces a new nano catalyst tailored for the eco-friendly synthesis of pyrido[2,3-d]pyrimidine via a three-component one-pot reaction involving benzaldehydes, malononitrile, and uracil. To achieve this objective, we anchored copper acetate onto the surface of layered double hydroxides modified with 1,3‑benzenedisulfonyl amide (BDSA) (LDH@PTRMS@BDSA@Cu(NO3)2), which exhibited remarkable activity and selectivity. The main benefits of this method include high product yield, swift reaction times, straightforward purification, catalyst reusability, and the employment of a mild reaction process. Furthermore, the catalyst maintained its effectiveness even after being recycled four times without notable degradation in catalytic performance. |
| format | Article |
| id | doaj-art-143d14804470486f8cae1dbd9198aac4 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-143d14804470486f8cae1dbd9198aac42025-01-17T04:50:19ZengElsevierHeliyon2405-84402025-01-01111e41149High-performance modified LDH for green one-pot synthesis of pyrido[2,3-d]pyrimidinesSarieh Momeni0Ramin Ghorbani-Vaghei1Department of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University, Hamedan, IranDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University, Hamedan, Iran; Department of Organic Chemistry, Faculty of Chemistry, Guilan University, Rasht, Iran; Corresponding author. Department of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University, Hamedan, Iran.This study introduces a new nano catalyst tailored for the eco-friendly synthesis of pyrido[2,3-d]pyrimidine via a three-component one-pot reaction involving benzaldehydes, malononitrile, and uracil. To achieve this objective, we anchored copper acetate onto the surface of layered double hydroxides modified with 1,3‑benzenedisulfonyl amide (BDSA) (LDH@PTRMS@BDSA@Cu(NO3)2), which exhibited remarkable activity and selectivity. The main benefits of this method include high product yield, swift reaction times, straightforward purification, catalyst reusability, and the employment of a mild reaction process. Furthermore, the catalyst maintained its effectiveness even after being recycled four times without notable degradation in catalytic performance.http://www.sciencedirect.com/science/article/pii/S2405844024171800Layered double hydroxidesLDHPyrido[2,3-d]pyrimidine derivativesMCRsNano catalyst |
| spellingShingle | Sarieh Momeni Ramin Ghorbani-Vaghei High-performance modified LDH for green one-pot synthesis of pyrido[2,3-d]pyrimidines Heliyon Layered double hydroxides LDH Pyrido[2,3-d]pyrimidine derivatives MCRs Nano catalyst |
| title | High-performance modified LDH for green one-pot synthesis of pyrido[2,3-d]pyrimidines |
| title_full | High-performance modified LDH for green one-pot synthesis of pyrido[2,3-d]pyrimidines |
| title_fullStr | High-performance modified LDH for green one-pot synthesis of pyrido[2,3-d]pyrimidines |
| title_full_unstemmed | High-performance modified LDH for green one-pot synthesis of pyrido[2,3-d]pyrimidines |
| title_short | High-performance modified LDH for green one-pot synthesis of pyrido[2,3-d]pyrimidines |
| title_sort | high performance modified ldh for green one pot synthesis of pyrido 2 3 d pyrimidines |
| topic | Layered double hydroxides LDH Pyrido[2,3-d]pyrimidine derivatives MCRs Nano catalyst |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024171800 |
| work_keys_str_mv | AT sariehmomeni highperformancemodifiedldhforgreenonepotsynthesisofpyrido23dpyrimidines AT raminghorbanivaghei highperformancemodifiedldhforgreenonepotsynthesisofpyrido23dpyrimidines |