Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma

Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma

Summary: Drug resistance is a major barrier to cancer therapies and remains poorly understood. Recently, non-mutational mechanisms of drug resistance have been proposed where a more plastic metabolic response can play a major role. Here, we show that upon drug resistance, glioblastoma (GBM) cells ha...

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Bibliographic Details
Main Authors: Deanna Tiek, Xiao Song, Xiaozhou Yu, Runxin Wu, Rebeca Iglesia, Alicia Catezone, Katy McCortney, Jordain Walshon, Craig Horbinski, Pouya Jamshidi, Rudolph Castellani, Robert Vassar, Jason Miska, Bo Hu, Shi-Yuan Cheng
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:iScience
Subjects:
Biological sciences
Neuroscience
Molecular neuroscience
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225000288
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