The Challenges of Local Intra-Articular Therapy
Fibroblast-like synoviocytes (FLSs) are among the main disease-driving players in most cases of monoarthritis (MonoA), oligoarthritis, and polyarthritis. In this review, we look at the characteristics and therapeutic challenges at the onset of arthritis and during follow-up management. In some cases...
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MDPI AG
2024-11-01
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| Online Access: | https://www.mdpi.com/1648-9144/60/11/1819 |
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| author | Gailute Kirdaite Jaroslav Denkovskij Diana Mieliauskaite Jolita Pachaleva Eiva Bernotiene |
| author_facet | Gailute Kirdaite Jaroslav Denkovskij Diana Mieliauskaite Jolita Pachaleva Eiva Bernotiene |
| author_sort | Gailute Kirdaite |
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| description | Fibroblast-like synoviocytes (FLSs) are among the main disease-driving players in most cases of monoarthritis (MonoA), oligoarthritis, and polyarthritis. In this review, we look at the characteristics and therapeutic challenges at the onset of arthritis and during follow-up management. In some cases, these forms of arthritis develop into autoimmune polyarthritis, such as rheumatoid arthritis (RA), whereas local eradication of the RA synovium could still be combined with systemic treatment using immunosuppressive agents. Currently, the outcomes of local synovectomies are well studied; however, there is still a lack of a comprehensive analysis of current local intra-articular treatments highlighting their advantages and disadvantages. Therefore, the aim of this study is to review local intra-articular therapy strategies. According to publications from the last decade on clinical studies focused on intra-articular treatment with anti-inflammatory molecules, a range of novel slow-acting forms of steroidal drugs for the local treatment of synovitis have been investigated. As pain is an essential symptom, caused by both inflammation and cartilage damage, various molecules acting on pain receptors are being investigated in clinical trials as potential targets for local intra-articular treatment. We also overview the new targets for local treatment, including surface markers and intracellular proteins, non-coding ribonucleic acids (RNAs), etc. |
| format | Article |
| id | doaj-art-13f731ff83cf43d898528e945af42cc4 |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-13f731ff83cf43d898528e945af42cc42024-11-26T18:12:32ZengMDPI AGMedicina1010-660X1648-91442024-11-016011181910.3390/medicina60111819The Challenges of Local Intra-Articular TherapyGailute Kirdaite0Jaroslav Denkovskij1Diana Mieliauskaite2Jolita Pachaleva3Eiva Bernotiene4Department of Personalised Medicine, State Research Institute Centre for Innovative Medicine, LT-08406 Vilnius, LithuaniaDepartment of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08406 Vilnius, LithuaniaDepartment of Personalised Medicine, State Research Institute Centre for Innovative Medicine, LT-08406 Vilnius, LithuaniaDepartment of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08406 Vilnius, LithuaniaDepartment of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08406 Vilnius, LithuaniaFibroblast-like synoviocytes (FLSs) are among the main disease-driving players in most cases of monoarthritis (MonoA), oligoarthritis, and polyarthritis. In this review, we look at the characteristics and therapeutic challenges at the onset of arthritis and during follow-up management. In some cases, these forms of arthritis develop into autoimmune polyarthritis, such as rheumatoid arthritis (RA), whereas local eradication of the RA synovium could still be combined with systemic treatment using immunosuppressive agents. Currently, the outcomes of local synovectomies are well studied; however, there is still a lack of a comprehensive analysis of current local intra-articular treatments highlighting their advantages and disadvantages. Therefore, the aim of this study is to review local intra-articular therapy strategies. According to publications from the last decade on clinical studies focused on intra-articular treatment with anti-inflammatory molecules, a range of novel slow-acting forms of steroidal drugs for the local treatment of synovitis have been investigated. As pain is an essential symptom, caused by both inflammation and cartilage damage, various molecules acting on pain receptors are being investigated in clinical trials as potential targets for local intra-articular treatment. We also overview the new targets for local treatment, including surface markers and intracellular proteins, non-coding ribonucleic acids (RNAs), etc.https://www.mdpi.com/1648-9144/60/11/1819monoarthritisinflammationsynovectomylocal treatmentfibroblast like synoviocytesnon-coding ribonucleic acids (RNAs) |
| spellingShingle | Gailute Kirdaite Jaroslav Denkovskij Diana Mieliauskaite Jolita Pachaleva Eiva Bernotiene The Challenges of Local Intra-Articular Therapy Medicina monoarthritis inflammation synovectomy local treatment fibroblast like synoviocytes non-coding ribonucleic acids (RNAs) |
| title | The Challenges of Local Intra-Articular Therapy |
| title_full | The Challenges of Local Intra-Articular Therapy |
| title_fullStr | The Challenges of Local Intra-Articular Therapy |
| title_full_unstemmed | The Challenges of Local Intra-Articular Therapy |
| title_short | The Challenges of Local Intra-Articular Therapy |
| title_sort | challenges of local intra articular therapy |
| topic | monoarthritis inflammation synovectomy local treatment fibroblast like synoviocytes non-coding ribonucleic acids (RNAs) |
| url | https://www.mdpi.com/1648-9144/60/11/1819 |
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