LPS pretreated dental follicle stem cell derived exosomes promote periodontal tissue regeneration via miR-184 and PPARα-Akt-JNK signaling pathway

LPS pretreated dental follicle stem cell derived exosomes promote periodontal tissue regeneration via miR-184 and PPARα-Akt-JNK signaling pathway

Abstract Purpose Lipopolysaccharide (LPS) pretreated dental follicle stem cells (DFSCs)-derived exosomes (L-D-Exo) exhibit enhanced therapeutic effects in periodontitis treatment, but the effective components responsible for these effects remain unidentified. The aim of this study is to investigate...

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Bibliographic Details
Main Authors: Liangrui Chen, Jiaxiang Zhang, Jialu Yu, Shujuan Guo, Weidong Tian
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Dental follicle stem cells
Exosomes
MicroRNA
Oxidative stress
Periodontal tissue regeneration
Online Access:https://doi.org/10.1186/s13287-025-04462-8
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