IGF2BP1 promotes the progression of head and neck squamous cell carcinoma by activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition

IGF2BP1 promotes the progression of head and neck squamous cell carcinoma by activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition

Abstract Background Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most prevalent cancer globally, with lymph node metastasis being a primary contributor to poor patient prognosis. Elucidating the molecular mechanisms driving HNSCC lymphatic metastasis is imperative for developing...

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Bibliographic Details
Main Authors: Ruibing Liu, Guohua Hu, Yanshi Li, Tao Lu, Min Pan, Mengna Wang, Zhaobo Cheng, Lin Chen
Format: Article
Language:English
Published: BMC 2025-07-01
Series:World Journal of Surgical Oncology
Subjects:
IGF2BP1
HNSCC
Metastasis
PI3K/AKT/mTOR pathway
EMT
Online Access:https://doi.org/10.1186/s12957-025-03929-5
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