Antidiarrheal Potential of Maja (Crescentia cujete) Fruit Extract in Mice
Diarrhea, characterized by frequent, loose stools, can be treated with various approaches. This study investigated the antidiarrheal properties of maja (Cresentia cujete) fruit extract, which contains secondary metabolites like tannins and flavonoids with astringent properties. The objective was to...
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| Format: | Article |
| Language: | English |
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Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya
2024-11-01
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| Series: | Borneo Journal of Pharmacy |
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| Online Access: | https://journal.umpr.ac.id/index.php/bjop/article/view/4712 |
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| author | Teodhora Teodhora Rosario Trijuliamos Manalu Richi Andika Saputra |
| author_facet | Teodhora Teodhora Rosario Trijuliamos Manalu Richi Andika Saputra |
| author_sort | Teodhora Teodhora |
| collection | DOAJ |
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Diarrhea, characterized by frequent, loose stools, can be treated with various approaches. This study investigated the antidiarrheal properties of maja (Cresentia cujete) fruit extract, which contains secondary metabolites like tannins and flavonoids with astringent properties. The objective was to determine the optimal dose of C. cujete fruit extract for treating diarrhea in mice. An in vivo experimental design was employed, inducing diarrhea in male mice using oleum ricini. The study assessed stools' onset, duration, consistency, frequency, and weight. Cresentia cujete fruit extract was administered orally at 125, 250, and 500 mg/kg BW doses. A comparison was made with negative control (CMC-NA) and positive controls (loperamide and attapulgite). Data analysis involved ANOVA followed by the Tukey test. The findings revealed that 500 mg/kg BW of C. cujete fruit extract was the most effective dose for treating diarrhea in mice. These results suggest the potential of C. cujete fruit extract as a promising natural antidiarrheal agent.
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| format | Article |
| id | doaj-art-13c8655c9a624bc49a1dafc2edab686c |
| institution | Kabale University |
| issn | 2621-4814 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya |
| record_format | Article |
| series | Borneo Journal of Pharmacy |
| spelling | doaj-art-13c8655c9a624bc49a1dafc2edab686c2025-01-08T08:42:14ZengInstitute for Researches and Community Services Universitas Muhammadiyah PalangkarayaBorneo Journal of Pharmacy2621-48142024-11-017410.33084/bjop.v7i4.4712Antidiarrheal Potential of Maja (Crescentia cujete) Fruit Extract in MiceTeodhora Teodhora0Rosario Trijuliamos Manalu1Richi Andika Saputra2National Institute of Science and TechnologyTaipei Medical UniversityNational Institute of Science and Technology Diarrhea, characterized by frequent, loose stools, can be treated with various approaches. This study investigated the antidiarrheal properties of maja (Cresentia cujete) fruit extract, which contains secondary metabolites like tannins and flavonoids with astringent properties. The objective was to determine the optimal dose of C. cujete fruit extract for treating diarrhea in mice. An in vivo experimental design was employed, inducing diarrhea in male mice using oleum ricini. The study assessed stools' onset, duration, consistency, frequency, and weight. Cresentia cujete fruit extract was administered orally at 125, 250, and 500 mg/kg BW doses. A comparison was made with negative control (CMC-NA) and positive controls (loperamide and attapulgite). Data analysis involved ANOVA followed by the Tukey test. The findings revealed that 500 mg/kg BW of C. cujete fruit extract was the most effective dose for treating diarrhea in mice. These results suggest the potential of C. cujete fruit extract as a promising natural antidiarrheal agent. https://journal.umpr.ac.id/index.php/bjop/article/view/4712AttapulgiteAntidiarrhealCrescentia cujeteLoperamide |
| spellingShingle | Teodhora Teodhora Rosario Trijuliamos Manalu Richi Andika Saputra Antidiarrheal Potential of Maja (Crescentia cujete) Fruit Extract in Mice Borneo Journal of Pharmacy Attapulgite Antidiarrheal Crescentia cujete Loperamide |
| title | Antidiarrheal Potential of Maja (Crescentia cujete) Fruit Extract in Mice |
| title_full | Antidiarrheal Potential of Maja (Crescentia cujete) Fruit Extract in Mice |
| title_fullStr | Antidiarrheal Potential of Maja (Crescentia cujete) Fruit Extract in Mice |
| title_full_unstemmed | Antidiarrheal Potential of Maja (Crescentia cujete) Fruit Extract in Mice |
| title_short | Antidiarrheal Potential of Maja (Crescentia cujete) Fruit Extract in Mice |
| title_sort | antidiarrheal potential of maja crescentia cujete fruit extract in mice |
| topic | Attapulgite Antidiarrheal Crescentia cujete Loperamide |
| url | https://journal.umpr.ac.id/index.php/bjop/article/view/4712 |
| work_keys_str_mv | AT teodhorateodhora antidiarrhealpotentialofmajacrescentiacujetefruitextractinmice AT rosariotrijuliamosmanalu antidiarrhealpotentialofmajacrescentiacujetefruitextractinmice AT richiandikasaputra antidiarrhealpotentialofmajacrescentiacujetefruitextractinmice |