Using a confined space to boost the driving amplitude of pulsating bubbles to facilitate jetting
A bubble collapsing near an interface may result in the formation of a liquid jet protruding from the distal bubble side, through the bubble, towards the interface. Ultrasound assisted jetting has been observed when subjecting, by approximation, infinite fluids to acoustic amplitudes above the inert...
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-12-01
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| Series: | Current Directions in Biomedical Engineering |
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| Online Access: | https://doi.org/10.1515/cdbme-2024-2035 |
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| author | Carlson Craig S. Anderton Nicole Aharonson Vered Otake Naoyuki Xinyue Hu Yamasaku Momoka Hashimoto Mamoru Kudo Nobuki Postema Michiel |
| author_facet | Carlson Craig S. Anderton Nicole Aharonson Vered Otake Naoyuki Xinyue Hu Yamasaku Momoka Hashimoto Mamoru Kudo Nobuki Postema Michiel |
| author_sort | Carlson Craig S. |
| collection | DOAJ |
| description | A bubble collapsing near an interface may result in the formation of a liquid jet protruding from the distal bubble side, through the bubble, towards the interface. Ultrasound assisted jetting has been observed when subjecting, by approximation, infinite fluids to acoustic amplitudes above the inertial cavitation threshold, limiting the possibility of ultrasoundguided, bubble-assisted drug or gene delivery. However, the vascular system can be regarded as a finite fluid. The purpose of this study was to investigate the feasibility of lowamplitude jetting for fluid containing biocompatible cavitation nuclei, by placing the region of interest in a confined space to ensure a standing wave field. Droplets of QuantisonTMultrasound contrast agent were pipetted into a Perspex cylindrical compartment of 8-mm diameter and 2-mm height, which was part of an imaging system. The contrast agent was subjected to 3-cycle ultrasound pulses with a centre frequency of 1MHz whilst being observed at a frame rate of ten million frames per second. Jetting was observed to occur with microbubbles nucleated from the contrast agent in an acoustic regime whose free-field mechanical index was 0.6. Empirical curve matching showed a pulse amplification by a factor of six owing to the chosen geometry. Visible jet lengths of twice the bubble radius on the verge of collapse were measured. Owing to the confined space, the local acoustic amplitude was amplified to surpass the cavitation threshold. This finding is of interest for medical ultrasonic applications where the local environment comprises reflectors. |
| format | Article |
| id | doaj-art-13bc1bf41a1b4215b51292ed6ac1524a |
| institution | Kabale University |
| issn | 2364-5504 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj-art-13bc1bf41a1b4215b51292ed6ac1524a2025-01-02T05:56:33ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042024-12-0110414414710.1515/cdbme-2024-2035Using a confined space to boost the driving amplitude of pulsating bubbles to facilitate jettingCarlson Craig S.0Anderton Nicole1Aharonson Vered2Otake Naoyuki3Xinyue Hu4Yamasaku Momoka5Hashimoto Mamoru6Kudo Nobuki7Postema Michiel8Department of Electrical Engineering and Automation, Aalto University, Maarintie 8, 02150Espoo, FinlandDepartment of Biomedical Technology, Faculty of Medicine and Health Technology, Tampere University,Tampere, FinlandSchool of Electrical and Information Engineering, University of the Witwatersrand, Johannesburg,Braamfontein, South AfricaDivision of Bioengineering and Bioinformatics, Faculty of Information Science and Technology, Hokkaido University,Sapporo, JapanDivision of Bioengineering and Bioinformatics, Faculty of Information Science and Technology, Hokkaido University,Sapporo, JapanDivision of Bioengineering and Bioinformatics, Faculty of Information Science and Technology, Hokkaido University,Sapporo, JapanDivision of Bioengineering and Bioinformatics, Faculty of Information Science and Technology, Hokkaido University,Sapporo, JapanDivision of Bioengineering and Bioinformatics, Faculty of Information Science and Technology, Hokkaido University,Sapporo, JapanDepartment of Biomedical Technology, Faculty of Medicine and Health Technology, Tampere University,Tampere, FinlandA bubble collapsing near an interface may result in the formation of a liquid jet protruding from the distal bubble side, through the bubble, towards the interface. Ultrasound assisted jetting has been observed when subjecting, by approximation, infinite fluids to acoustic amplitudes above the inertial cavitation threshold, limiting the possibility of ultrasoundguided, bubble-assisted drug or gene delivery. However, the vascular system can be regarded as a finite fluid. The purpose of this study was to investigate the feasibility of lowamplitude jetting for fluid containing biocompatible cavitation nuclei, by placing the region of interest in a confined space to ensure a standing wave field. Droplets of QuantisonTMultrasound contrast agent were pipetted into a Perspex cylindrical compartment of 8-mm diameter and 2-mm height, which was part of an imaging system. The contrast agent was subjected to 3-cycle ultrasound pulses with a centre frequency of 1MHz whilst being observed at a frame rate of ten million frames per second. Jetting was observed to occur with microbubbles nucleated from the contrast agent in an acoustic regime whose free-field mechanical index was 0.6. Empirical curve matching showed a pulse amplification by a factor of six owing to the chosen geometry. Visible jet lengths of twice the bubble radius on the verge of collapse were measured. Owing to the confined space, the local acoustic amplitude was amplified to surpass the cavitation threshold. This finding is of interest for medical ultrasonic applications where the local environment comprises reflectors.https://doi.org/10.1515/cdbme-2024-2035liquid jetshigh-speed photographyultrasound contrast agentquantison™standing field |
| spellingShingle | Carlson Craig S. Anderton Nicole Aharonson Vered Otake Naoyuki Xinyue Hu Yamasaku Momoka Hashimoto Mamoru Kudo Nobuki Postema Michiel Using a confined space to boost the driving amplitude of pulsating bubbles to facilitate jetting Current Directions in Biomedical Engineering liquid jets high-speed photography ultrasound contrast agent quantison™ standing field |
| title | Using a confined space to boost the driving amplitude of pulsating bubbles to facilitate jetting |
| title_full | Using a confined space to boost the driving amplitude of pulsating bubbles to facilitate jetting |
| title_fullStr | Using a confined space to boost the driving amplitude of pulsating bubbles to facilitate jetting |
| title_full_unstemmed | Using a confined space to boost the driving amplitude of pulsating bubbles to facilitate jetting |
| title_short | Using a confined space to boost the driving amplitude of pulsating bubbles to facilitate jetting |
| title_sort | using a confined space to boost the driving amplitude of pulsating bubbles to facilitate jetting |
| topic | liquid jets high-speed photography ultrasound contrast agent quantison™ standing field |
| url | https://doi.org/10.1515/cdbme-2024-2035 |
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