Stem Cells in Solid Tumors: Accumulated Evidence and Future Directions
Cancer stands as a leading global cause of human mortality, predominantly driven by solid tumors that can ravage vital organs. The scientific community has made significant strides in comprehending the molecular and cellular underpinnings of cancer. However, translating these discoveries into effect...
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| Format: | Article |
| Language: | English |
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Jaypee Brothers Medical Publisher
2024-04-01
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| Series: | Indian Journal of Medical Biochemistry |
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| Online Access: | https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0225 |
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| author | Deepthi Venkatachalapathy Parveen Doddamani Aradya V Hirriyannaiah Prashant Vishwanath Suma Nataraj Akila Prashant |
| author_facet | Deepthi Venkatachalapathy Parveen Doddamani Aradya V Hirriyannaiah Prashant Vishwanath Suma Nataraj Akila Prashant |
| author_sort | Deepthi Venkatachalapathy |
| collection | DOAJ |
| description | Cancer stands as a leading global cause of human mortality, predominantly driven by solid tumors that can ravage vital organs. The scientific community has made significant strides in comprehending the molecular and cellular underpinnings of cancer. However, translating these discoveries into effective, targeted therapeutics has proven challenging. This gap highlights the existence of critical bottlenecks hindering the journey from fundamental research findings to fully realized anticancer drugs. Recent insights into cancer biology have illuminated one potential bottleneck: the presence of cancer stem cells (CSCs). These represent a minority subset of cells within a tumor, believed to orchestrate the relentless growth of the entire tumor. The concept of CSCs has gained substantial traction, thanks to advancements in stem cell research. Developing more potent and precise cancer therapies hinges on our ability to identify and understand these cancer-initiating cells within solid tumors. It is essential to discern how CSCs differ from other cancer cells coexisting in the same tissue. This review endeavors to compile the accumulated scientific evidence supporting the existence of CSCs, elucidate the cell surface markers employed for their isolation, dissect the pathways governing their self-renewal and differentiation, and outline future directions for harnessing them as therapeutic targets to eradicate tumor growth comprehensively. |
| format | Article |
| id | doaj-art-13a28a4b858c46cc94f40cb66d73332f |
| institution | Kabale University |
| issn | 2456-5164 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Indian Journal of Medical Biochemistry |
| spelling | doaj-art-13a28a4b858c46cc94f40cb66d73332f2025-01-03T07:48:11ZengJaypee Brothers Medical PublisherIndian Journal of Medical Biochemistry2456-51642024-04-0128124010.5005/jp-journals-10054-02251Stem Cells in Solid Tumors: Accumulated Evidence and Future DirectionsDeepthi Venkatachalapathy0Parveen Doddamani1Aradya V Hirriyannaiah2Prashant Vishwanath3Suma Nataraj4Akila Prashant5Center of Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Karnataka, IndiaCenter of Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Karnataka, IndiaDepartment of Gastroenterology, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Karnataka, IndiaCenter of Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Karnataka, IndiaCenter of Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College; Special Interest Group on Human Genomics and Rare Disorders (SIG-HGRD), JSS Academy of Higher Education & Research, Mysuru, Karnataka, IndiaAkila Prashant, Center of Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College; Special Interest Group on Human Genomics and Rare Disorders (SIG-HGRD), JSS Academy of Higher Education & Research, Mysuru, Karnataka, India, Phone: +91 9008097970Cancer stands as a leading global cause of human mortality, predominantly driven by solid tumors that can ravage vital organs. The scientific community has made significant strides in comprehending the molecular and cellular underpinnings of cancer. However, translating these discoveries into effective, targeted therapeutics has proven challenging. This gap highlights the existence of critical bottlenecks hindering the journey from fundamental research findings to fully realized anticancer drugs. Recent insights into cancer biology have illuminated one potential bottleneck: the presence of cancer stem cells (CSCs). These represent a minority subset of cells within a tumor, believed to orchestrate the relentless growth of the entire tumor. The concept of CSCs has gained substantial traction, thanks to advancements in stem cell research. Developing more potent and precise cancer therapies hinges on our ability to identify and understand these cancer-initiating cells within solid tumors. It is essential to discern how CSCs differ from other cancer cells coexisting in the same tissue. This review endeavors to compile the accumulated scientific evidence supporting the existence of CSCs, elucidate the cell surface markers employed for their isolation, dissect the pathways governing their self-renewal and differentiation, and outline future directions for harnessing them as therapeutic targets to eradicate tumor growth comprehensively.https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0225 cancer stem cellsmicrornatumor initiating celltumor microenvironments |
| spellingShingle | Deepthi Venkatachalapathy Parveen Doddamani Aradya V Hirriyannaiah Prashant Vishwanath Suma Nataraj Akila Prashant Stem Cells in Solid Tumors: Accumulated Evidence and Future Directions Indian Journal of Medical Biochemistry cancer stem cells microrna tumor initiating cell tumor microenvironments |
| title | Stem Cells in Solid Tumors: Accumulated Evidence and Future Directions |
| title_full | Stem Cells in Solid Tumors: Accumulated Evidence and Future Directions |
| title_fullStr | Stem Cells in Solid Tumors: Accumulated Evidence and Future Directions |
| title_full_unstemmed | Stem Cells in Solid Tumors: Accumulated Evidence and Future Directions |
| title_short | Stem Cells in Solid Tumors: Accumulated Evidence and Future Directions |
| title_sort | stem cells in solid tumors accumulated evidence and future directions |
| topic | cancer stem cells microrna tumor initiating cell tumor microenvironments |
| url | https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0225 |
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